| 37890156 | Acute myeloid leukemias with UBTF tandem duplications are sensitive to menin inhibitors. | Blood | 2024 |
| 38084912 | A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR. | Nucleic Acids Res | 2024 |
| 36116789 | Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond. | Drug Metab Dispos | 2023 |
| 37957169 | A CRISPR-drug perturbational map for identifying compounds to combine with commonly used chemotherapeutics. | Nat Commun | 2023 |
| 37849548 | Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small-Molecule Inhibitors. | ACS Med Chem Lett | 2023 |
| 37729916 | Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand. | Structure | 2023 |
| 37969738 | The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation. | Acta Pharm Sin B | 2023 |
| 37414763 | Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma. | Nat Commun | 2023 |
| 37224250 | Mitophagy restricts BAX/BAK-independent, Parkin-mediated apoptosis. | Sci Adv | 2023 |
| 36781850 | Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia. | Nat Commun | 2023 |
| 36848571 | Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein. | Proc Natl Acad Sci U S A | 2023 |
| 36805760 | Breast cancer cells that preferentially metastasize to lung or bone are more glycolytic, synthesize serine at greater rates, and consume less ATP and NADPH than parent MDA-MB-231 cells. | Cancer Metab | 2023 |
| 36805027 | E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity. | Mol Cell | 2023 |
| 36894563 | Author Correction: Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia. | Nat Commun | 2023 |
| 35969671 | Evaluation of a Pooling Chemoproteomics Strategy with an FDA-Approved Drug Library. | Biochemistry | 2023 |
| 35212371 | Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation. | Nucleic Acids Res | 2022 |
| 35537449 | NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition. | Mol Cell | 2022 |
| 35857643 | Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma. | Sci Transl Med | 2022 |
| 36480704 | Design and Optimization of 1<i>H</i>-1,2,3-Triazole-4-carboxamides as Novel, Potent, and Selective Inverse Agonists and Antagonists of PXR. | J Med Chem | 2022 |
| 36636325 | Alzheimer's disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment. | Nat Aging | 2022 |
| 36147946 | Small molecule SJ572946 activates BAK to initiate apoptosis. | iScience | 2022 |
| 36262390 | Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader. | ACS Med Chem Lett | 2022 |
| 35978691 | SJPYT-195: A Designed Nuclear Receptor Degrader That Functions as a Molecular Glue Degrader of GSPT1. | ACS Med Chem Lett | 2022 |
| 32232515 | Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning. | Cell Mol Life Sci | 2021 |
| 33495337 | Targeting OCT3 attenuates doxorubicin-induced cardiac injury. | Proc Natl Acad Sci U S A | 2021 |
| 33742760 | Identification of small molecules that mitigate vincristine-induced neurotoxicity while sensitizing leukemia cells to vincristine. | Clin Transl Sci | 2021 |
| 33860212 | General Stepwise Approach to Optimize a TR-FRET Assay for Characterizing the BRD/PROTAC/CRBN Ternary Complex. | ACS Pharmacol Transl Sci | 2021 |
| 33664059 | Regulation of OATP1B1 Function by Tyrosine Kinase-mediated Phosphorylation. | Clin Cancer Res | 2021 |
| 33497575 | Building a Chemical Toolbox for Human Pregnane X Receptor Research: Discovery of Agonists, Inverse Agonists, and Antagonists Among Analogs Based on the Unique Chemical Scaffold of SPA70. | J Med Chem | 2021 |
| 34648292 | Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5. | J Am Chem Soc | 2021 |
| 34614283 | Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs. | Angew Chem Int Ed Engl | 2021 |
| 34753908 | The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma. | Nat Commun | 2021 |
| 34485934 | A protocol for high-throughput screening of histone lysine demethylase 4 inhibitors using TR-FRET assay. | STAR Protoc | 2021 |
| 34482171 | Biological evaluation and synthesis of calcitroic acid. | Bioorg Chem | 2021 |
| 34215733 | Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma. | Nat Commun | 2021 |
| 32317630 | A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury. | Nat Commun | 2020 |
| 33490904 | 17-DMAG dually inhibits Hsp90 and histone lysine demethylases in alveolar rhabdomyosarcoma. | iScience | 2020 |
| 32001790 | KANSL2 and MBNL3 are regulators of pancreatic ductal adenocarcinoma invasion. | Sci Rep | 2020 |
| 31965799 | Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5. | J Med Chem | 2020 |
| 31782213 | Strategies for developing pregnane X receptor antagonists: Implications from metabolism to cancer. | Med Res Rev | 2020 |
| 31887254 | Discovery and Characterization of the Antimetabolite Action of Thioacetamide-Linked 1,2,3-Triazoles as Disruptors of Cysteine Biosynthesis in Gram-Negative Bacteria. | ACS Infect Dis | 2020 |
| 32067270 | ABCG2 requires a single aromatic amino acid to "clamp" substrates and inhibitors into the binding pocket. | FASEB J | 2020 |
| 31882411 | CITCO Directly Binds to and Activates Human Pregnane X Receptor. | Mol Pharmacol | 2020 |
| 33458521 | Development of BODIPY FL VH032 as a High-Affinity and Selective von Hippel-Lindau E3 Ligase Fluorescent Probe and Its Application in a Time-Resolved Fluorescence Resonance Energy-Transfer Assay. | ACS Omega | 2020 |
| 33101709 | MEKK3-MEK5-ERK5 signaling promotes mitochondrial degradation. | Cell Death Discov | 2020 |
| 33268358 | BRAF inhibition protects against hearing loss in mice. | Sci Adv | 2020 |
| 33070611 | Development of BODIPY FL Thalidomide As a High-Affinity Fluorescent Probe for Cereblon in a Time-Resolved Fluorescence Resonance Energy Transfer Assay. | Bioconjug Chem | 2020 |
| 33004795 | Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases. | Nat Commun | 2020 |
| 32660103 | Toxicoproteomic Profiling of <i>hPXR</i> Transgenic Mice Treated with Rifampicin and Isoniazid. | Cells | 2020 |
| 32651255 | Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer. | Cancer Res | 2020 |