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Author Details

Taosheng Chen
St. Jude Children's Research Hospital
1997
168
38
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37890156Acute myeloid leukemias with UBTF tandem duplications are sensitive to menin inhibitors.Blood2024
38084912A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR.Nucleic Acids Res2024
36116789Regulation of Nuclear Receptors PXR and CAR by Small Molecules and Signal Crosstalk: Roles in Drug Metabolism and Beyond.Drug Metab Dispos2023
37957169A CRISPR-drug perturbational map for identifying compounds to combine with commonly used chemotherapeutics.Nat Commun2023
37849548Fragment-Based NMR Screening of the BPTF PHD Finger Methyl Lysine Reader Leads to the First Small-Molecule Inhibitors.ACS Med Chem Lett2023
37729916Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand.Structure2023
37969738The F-box-only protein 44 regulates pregnane X receptor protein level by ubiquitination and degradation.Acta Pharm Sin B2023
37414763Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma.Nat Commun2023
37224250Mitophagy restricts BAX/BAK-independent, Parkin-mediated apoptosis.Sci Adv2023
36781850Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia.Nat Commun2023
36848571Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein.Proc Natl Acad Sci U S A2023
36805760Breast cancer cells that preferentially metastasize to lung or bone are more glycolytic, synthesize serine at greater rates, and consume less ATP and NADPH than parent MDA-MB-231 cells.Cancer Metab2023
36805027E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.Mol Cell2023
36894563Author Correction: Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia.Nat Commun2023
35969671Evaluation of a Pooling Chemoproteomics Strategy with an FDA-Approved Drug Library.Biochemistry2023
35212371Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation.Nucleic Acids Res2022
35537449NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition.Mol Cell2022
35857643Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma.Sci Transl Med2022
36480704Design and Optimization of 1<i>H</i>-1,2,3-Triazole-4-carboxamides as Novel, Potent, and Selective Inverse Agonists and Antagonists of PXR.J Med Chem2022
36636325Alzheimer's disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment.Nat Aging2022
36147946Small molecule SJ572946 activates BAK to initiate apoptosis.iScience2022
36262390Development of an N-Terminal BRD4 Bromodomain-Targeted Degrader.ACS Med Chem Lett2022
35978691SJPYT-195: A Designed Nuclear Receptor Degrader That Functions as a Molecular Glue Degrader of GSPT1.ACS Med Chem Lett2022
32232515Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning.Cell Mol Life Sci2021
33495337Targeting OCT3 attenuates doxorubicin-induced cardiac injury.Proc Natl Acad Sci U S A2021
33742760Identification of small molecules that mitigate vincristine-induced neurotoxicity while sensitizing leukemia cells to vincristine.Clin Transl Sci2021
33860212General Stepwise Approach to Optimize a TR-FRET Assay for Characterizing the BRD/PROTAC/CRBN Ternary Complex.ACS Pharmacol Transl Sci2021
33664059Regulation of OATP1B1 Function by Tyrosine Kinase-mediated Phosphorylation.Clin Cancer Res2021
33497575Building a Chemical Toolbox for Human Pregnane X Receptor Research: Discovery of Agonists, Inverse Agonists, and Antagonists Among Analogs Based on the Unique Chemical Scaffold of SPA70.J Med Chem2021
34648292Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5.J Am Chem Soc2021
34614283Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs.Angew Chem Int Ed Engl2021
34753908The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma.Nat Commun2021
34485934A protocol for high-throughput screening of histone lysine demethylase 4 inhibitors using TR-FRET assay.STAR Protoc2021
34482171Biological evaluation and synthesis of calcitroic acid.Bioorg Chem2021
34215733Patient-derived models recapitulate heterogeneity of molecular signatures and drug response in pediatric high-grade glioma.Nat Commun2021
32317630A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury.Nat Commun2020
3349090417-DMAG dually inhibits Hsp90 and histone lysine demethylases in alveolar rhabdomyosarcoma.iScience2020
32001790KANSL2 and MBNL3 are regulators of pancreatic ductal adenocarcinoma invasion.Sci Rep2020
31965799Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5.J Med Chem2020
31782213Strategies for developing pregnane X receptor antagonists: Implications from metabolism to cancer.Med Res Rev2020
31887254Discovery and Characterization of the Antimetabolite Action of Thioacetamide-Linked 1,2,3-Triazoles as Disruptors of Cysteine Biosynthesis in Gram-Negative Bacteria.ACS Infect Dis2020
32067270ABCG2 requires a single aromatic amino acid to "clamp" substrates and inhibitors into the binding pocket.FASEB J2020
31882411CITCO Directly Binds to and Activates Human Pregnane X Receptor.Mol Pharmacol2020
33458521Development of BODIPY FL VH032 as a High-Affinity and Selective von Hippel-Lindau E3 Ligase Fluorescent Probe and Its Application in a Time-Resolved Fluorescence Resonance Energy-Transfer Assay.ACS Omega2020
33101709MEKK3-MEK5-ERK5 signaling promotes mitochondrial degradation.Cell Death Discov2020
33268358BRAF inhibition protects against hearing loss in mice.Sci Adv2020
33070611Development of BODIPY FL Thalidomide As a High-Affinity Fluorescent Probe for Cereblon in a Time-Resolved Fluorescence Resonance Energy Transfer Assay.Bioconjug Chem2020
33004795Structural basis for substrate recognition and chemical inhibition of oncogenic MAGE ubiquitin ligases.Nat Commun2020
32660103Toxicoproteomic Profiling of <i>hPXR</i> Transgenic Mice Treated with Rifampicin and Isoniazid.Cells2020
32651255Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer.Cancer Res2020
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Collaborators

St. Jude Children's Research Hospital
Co-authored papers 52
St. Jude Children's Research Hospital
Co-authored papers 20
St. Jude Children's Research Hospital
Co-authored papers 15
St. Jude Children's Research Hospital
Co-authored papers 11
St. Jude Children's Research Hospital.
Co-authored papers 8
St. Jude Children's Research Hospital
Co-authored papers 7
Ohio State University
Co-authored papers 6
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 5
The Ohio State University
Co-authored papers 5
The Ohio State University
Co-authored papers 5
Ohio State University
Co-authored papers 5
Molecular Biology Institute, University of California los angeles
Co-authored papers 4
Second Affiliated Hospital of Harbin Medical University
Co-authored papers 4
St Jude Children's Research Hospital
Co-authored papers 4
Sino-French Hoffmann Institute, Guangzhou Medical University
Co-authored papers 4
Co-authored papers 3
School of Pharmacy and Pharmaceutical Sciences, University at Buffalo
Co-authored papers 3
Departments of Oncology. St. Jude Children's Research Hospital
Co-authored papers 3
St. Jude Children's Research Hospital
Co-authored papers 3
The Ohio State University
Co-authored papers 3
St Jude Children's Research Hospital
Co-authored papers 2
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Co-authored papers 2
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St Jude Children's Research Hospital
Co-authored papers 2
Mayo Clinic
Co-authored papers 2
and University of Tuebingen, University of Tuebingen
Co-authored papers 2
University of Minnesota
Co-authored papers 2
The Scripps Research Institute
Co-authored papers 2
Departments of Pharmaceutical Sciences.
Co-authored papers 2
University Hospital Munster
Co-authored papers 2