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Author Details

Navjotsingh Pabla
The Ohio State University
2006
44
25
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36798313A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective.bioRxiv2023
37084253Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective.ACS Chem Neurosci2023
37132760CDK4/6 and autophagy inhibitors synergize to suppress the growth of human head and neck squamous cell carcinomas.Mol Carcinog2023
37333314IL-22 promotes acute kidney injury through activation of the DNA damage response and cell death in proximal tubule cells.bioRxiv2023
37162893Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology.bioRxiv2023
36921719Zinc finger protein 24-dependent transcription factor SOX9 up-regulation protects tubular epithelial cells during acute kidney injury.Kidney Int2023
36778297Tubular Mitochondrial Pyruvate Carrier Disruption Elicits Redox Adaptations that Protect from Acute Kidney Injury.bioRxiv2023
34883481Role of Mitochondrial Therapy for Ischemic-Reperfusion Injury and Acute Kidney Injury.Nephron2022
35797240BMX kinase mediates gilteritinib resistance in FLT3-mutated AML through microenvironmental factors.Blood Adv2022
35958610Targeting ETosis by miR-155 inhibition mitigates mixed granulocytic asthmatic lung inflammation.Front Immunol2022
34534550Kidney toxicity of the BRAF-kinase inhibitor vemurafenib is driven by off-target ferrochelatase inhibition.Kidney Int2021
34614509Gilteritinib-induced upregulation of S100A9 is mediated through BCL6 in acute myeloid leukemia.Blood Adv2021
32317630A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury.Nat Commun2020
33044867Involvement of the CDKL5-SOX9 signaling axis in rhabdomyolysis-associated acute kidney injury.Am J Physiol Renal Physiol2020
32887795SOX9 promotes stress-responsive transcription of VGF nerve growth factor inducible gene in renal tubular epithelial cells.J Biol Chem2020
32484793Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice.J Clin Invest2020
30288751FoxO1 is a critical regulator of M2-like macrophage activation in allergic asthma.Allergy2019
29227282Hypoxia-induced upregulation of BMX kinase mediates therapeutic resistance in acute myeloid leukemia.J Clin Invest2018
27804130Role of Passive Diffusion, Transporters, and Membrane Trafficking-Mediated Processes in Cellular Drug Transport.Clin Pharmacol Ther2017
28209616OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues.Cancer Res2017
28689374Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity.Clin Transl Sci2017
26979622A phosphotyrosine switch regulates organic cation transporters.Nat Commun2016
25587068MicroRNA-687 Induced by Hypoxia-Inducible Factor-1 Targets Phosphatase and Tensin Homolog in Renal Ischemia-Reperfusion Injury.J Am Soc Nephrol2015
26564230DNA damage response in cisplatin-induced nephrotoxicity.Arch Toxicol2015
25848011Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions.Proc Natl Acad Sci U S A2015
25770292CCR 20th anniversary commentary: BMS-247550â¿¿microtubule stabilization as successful targeted therapy.Clin Cancer Res2015
24916697Cisplatin-induced renal injury is independently mediated by OCT2 and p53.Clin Cancer Res2014
23255108Nek1 phosphorylates Von Hippel-Lindau tumor suppressor to promote its proteasomal degradation and ciliary destabilization.Cell Cycle2013
23851348Nek1 interacts with Ku80 to assist chromatin loading of replication factors and S-phase progression.Cell Cycle2013
23508805Checkpoint kinase 1 in DNA damage response and cell cycle regulation.Cell Mol Life Sci2013
22184239Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints.Proc Natl Acad Sci U S A2012
22544330Sibling rivalry in checkpoint control of cell cycle and DNA damage response.Cell Cycle2012
22403741Curtailing side effects in chemotherapy: a tale of PKCδ in cisplatin treatment.Oncotarget2012
21285353hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis.J Biol Chem2011
21633170Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer.J Clin Invest2011
20395372PKC-delta promotes renal tubular cell apoptosis associated with proteinuria.J Am Soc Nephrol2010
19144690The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity.Am J Physiol Renal Physiol2009
18160625Effects of targeted Bcl-2 expression in mitochondria or endoplasmic reticulum on renal tubular cell apoptosis.Am J Physiol Renal Physiol2008
18272962Cisplatin nephrotoxicity: mechanisms and renoprotective strategies.Kidney Int2008
18162465ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis.J Biol Chem2008
17130128Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activation.J Biol Chem2007
17291459Effects of hydroxyl radical scavenging on cisplatin-induced p53 activation, tubular cell apoptosis and nephrotoxicity.Biochem Pharmacol2007
16849690Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: inactivation of its kinase activity toward p53.Am J Physiol Renal Physiol2006
17122151Expression, subcellular localization, and regulation of sigma receptor in retinal muller cells.Invest Ophthalmol Vis Sci2006
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Collaborators

Alex Sparreboom
Ohio State University
Co-authored papers 10
Sharyn D Baker
Ohio State University
Co-authored papers 8
Lie Li
Sino-French Hoffmann Institute, Guangzhou Medical University
Co-authored papers 6
Alice A Gibson
The Ohio State University
Co-authored papers 6
Jason A Sprowl
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Co-authored papers 5
Shuiying Hu
The Ohio State University
Co-authored papers 5
Giuliano Ciarimboli
University Hospital Munster
Co-authored papers 4
Eberhard Schlatter
University Hospital Muenster
Co-authored papers 4
Su Sien Ong
St. Jude Children's Research Hospital
Co-authored papers 3
Guoqing Du
Second Affiliated Hospital of Harbin Medical University
Co-authored papers 3
Aksana Vasilyeva
St Jude Children's Research Hospital
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Taosheng Chen
St. Jude Children's Research Hospital
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Shuang Huang
Co-authored papers 3
Daelynn R Buelow
The Ohio State University
Co-authored papers 3
Jan H M Schellens
Department of Pharmaceutical Sciences, Utrecht University
Co-authored papers 2
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NeuroMI (Milan Center for Neuroscience)
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Matthias Schwab
and of Biochemistry and Pharmacy, University of Tuebingen
Co-authored papers 2
Anne T Nies
and University of Tuebingen, University of Tuebingen
Co-authored papers 2
Katalin Susztak
Perelman School of Medicine, University of Pennsylvania
Co-authored papers 2
Stanley Pounds
St. Jude Children's Research Hospital.
Co-authored papers 2
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 1
Shashank Bharill
University of California berkeley
Co-authored papers 1
Robert B Diasio
Mayo Clinic
Co-authored papers 1
Rachel A Ness
4Department of Pharmacy, Memphis Veterans Affairs Medical Center
Co-authored papers 1
Samir M Parikh
The Ohio State University Wexner Medical Center
Co-authored papers 1
Ehud Y Isacoff
University of California berkeley
Co-authored papers 1
Charles L Loprinzi
Mayo Clinic
Co-authored papers 1
Wenwei Lin
St. Jude Children's Research Hospital
Co-authored papers 1
Adrian Stecula
Schools of Pharmacy and Medicine, University of California san francisco
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Release 1.2