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Author Details

Timothy J Ley
Washington University School of Medicine
1982
266
96
PMIDPaper TitleJournal TitlePublished Year
36179268Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions.Blood2023
38061017Proteogenomic analysis reveals cytoplasmic sequestration of RUNX1 by the acute myeloid leukemia-initiating CBFB::MYH11 oncofusion protein.J Clin Invest2023
37160317Melanoma in a patient with DNMT3A overgrowth syndrome.Cold Spring Harb Mol Case Stud2023
37079859Persistent Molecular Disease in Adult Patients With AML Evaluated With Whole-Exome and Targeted Error-Corrected DNA Sequencing.JCO Precis Oncol2023
37339484Genomic landscape of TP53-mutated myeloid malignancies.Blood Adv2023
36711871Genomic landscape of <i>TP53</i> -mutated myeloid malignancies.medRxiv2023
34788385DNMT3A overgrowth syndrome is associated with the development of hematopoietic malignancies in children and young adults.Blood2022
35709710Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression.Blood Cancer Discov2022
35349197Physician-scientists in the United States at 2020: Trends and concerns.FASEB J2022
35675516IL-1β expression in bone marrow dendritic cells is induced by TLR2 agonists and regulates HSC function.Blood2022
35429619Recurrent transcriptional responses in AML and MDS patients treated with decitabine.Exp Hematol2022
35864110Author Correction: A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing.Nat Commun2022
35895896Proteomic and phosphoproteomic landscapes of acute myeloid leukemia.Blood2022
35041928Failure to Detect Mutations in U2AF1 due to Changes in the GRCh38 Reference Sequence.J Mol Diagn2022
35313694Somatic <i>Dnmt3a</i> inactivation leads to slow, canonical DNA methylation loss in murine hematopoietic cells.iScience2022
34873300Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells.Leukemia2022
35236053Decitabine salvage for <i>TP53</i>-mutated, relapsed/refractory acute myeloid leukemia after cytotoxic induction therapy.Haematologica2022
35019859Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia.Blood Cancer Discov2022
34670359Tumor suppressor function of <i>WT1</i> in acute promyelocytic leukemia.Haematologica2022
33388420Enhanced Efficacy and Increased Long-Term Toxicity of CNS-Directed, AAV-Based Combination Therapy for Krabbe Disease.Mol Ther2021
33846253Dnmt3a deficiency in the skin causes focal, canonical DNA hypomethylation and a cellular proliferation phenotype.Proc Natl Acad Sci U S A2021
33704937Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers.N Engl J Med2021
34845035Immunosuppression and outcomes in adult patients with de novo acute myeloid leukemia with normal karyotypes.Proc Natl Acad Sci U S A2021
33963182Co-evolution of tumor and immune cells during progression of multiple myeloma.Nat Commun2021
34125173Tumor suppressor function of Gata2 in acute promyelocytic leukemia.Blood2021
34036230Impact of a 40-Gene Targeted Panel Test on Physician Decision Making for Patients With Acute Myeloid Leukemia.JCO Precis Oncol2021
34341766Bam-readcount - rapid generation of basepair-resolution sequence metrics.ArXiv2021
34315901Functional and epigenetic phenotypes of humans and mice with DNMT3A Overgrowth Syndrome.Nat Commun2021
31515354Obesity is a risk factor for acute promyelocytic leukemia: evidence from population and cross-sectional studies and correlation with FLT3 mutations and polyunsaturated fatty acid metabolism.Haematologica2020
31996479Remethylation of <i>Dnmt3a</i><sup>-/-</sup> hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing.Proc Natl Acad Sci U S A2020
32577507The clonal evolution of metastatic colorectal cancer.Sci Adv2020
32358485Long non-coding RNA RAMS11 promotes metastatic colorectal cancer progression.Nat Commun2020
31413257A general approach for detecting expressed mutations in AML cells using single cell RNA-sequencing.Nat Commun2019
29365324Expression profiling of snoRNAs in normal hematopoiesis and AML.Blood Adv2018
30207916Mutation Clearance after Transplantation for Myelodysplastic Syndrome.N Engl J Med2018
30380364Immune Escape of Relapsed AML Cells after Allogeneic Transplantation.N Engl J Med2018
29386642Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential.Nat Commun2018
29724719<i>MIR142</i> Loss-of-Function Mutations Derepress ASH1L to Increase <i>HOXA</i> Gene Expression and Promote Leukemogenesis.Cancer Res2018
29634818Sequencing of Tumor DNA to Guide Cancer Risk Assessment and Therapy.JAMA2018
29515031Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant.JCI Insight2018
29618788DNMT3A<sup>R882</sup>-associated hypomethylation patterns are maintained in primary AML xenografts, but not in the DNMT3A<sup>R882C</sup> OCI-AML3 leukemia cell line.Blood Cancer J2018
27740633Dynamic changes in the clonal structure of MDS and AML in response to epigenetic therapy.Leukemia2017
28225682Decitabine in TP53-Mutated AML.N Engl J Med2017
28082444Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy.Blood2017
28215704CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.Cell2017
28872462Haploinsufficiency for DNA methyltransferase 3A predisposes hematopoietic cells to myeloid malignancies.J Clin Invest2017
28760689Comprehensive discovery of noncoding RNAs in acute myeloid leukemia cell transcriptomes.Exp Hematol2017
27181063Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia.Exp Hematol2016
26631115Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML.Blood2016
26595813PML-RARA requires DNA methyltransferase 3A to initiate acute promyelocytic leukemia.J Clin Invest2016
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Collaborators

Richard K Wilson
The Ohio State University
Co-authored papers 62
Christopher A Miller
Washington University School of Medicine
Co-authored papers 60
Robert S Fulton
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 59
Daniel C Link
Washington University School of Medicine
Co-authored papers 55
Matthew J Walter
Washington University School of Medicine in St. Louis
Co-authored papers 54
John F DiPersio
Washington University School of Medicine
Co-authored papers 52
Elaine R Mardis
The Ohio State University
Co-authored papers 50
Peter Westervelt
Washington University School of Medicine
Co-authored papers 46
Timothy A Graubert
Massachusetts General Hospital
Co-authored papers 45
Sharon E Heath
Washington University School of Medicine.
Co-authored papers 41
Li Ding
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 37
Jacqueline E Payton
Washington University School of Medicine.
Co-authored papers 32
Catrina Fronick
McDonnell Genome Institute, Washington University in St. Louis School of Medicine
Co-authored papers 29
Michael D McLellan
McDonnell Genome Institute, Washington University in St. Louis
Co-authored papers 28
Michelle O'Laughlin
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 25
David H Spencer
Washington University School of Medicine.
Co-authored papers 23
David E Larson
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 22
Jeffery M Klco
St. Jude Children's Research Hospital
Co-authored papers 21
Vincent Magrini
The Ohio State University
Co-authored papers 18
Daniel C Koboldt
Institute for Genomic Medicine, Nationwide Children's Hospital
Co-authored papers 17
Ken Chen
University of Texas MD Anderson Cancer Center
Co-authored papers 16
Tamara L Lamprecht
St. Jude Children's Research Hospital
Co-authored papers 16
Mark A Watson
Washington University School of Medicine
Co-authored papers 16
Rakesh Nagarajan
Current or past members of the College of American Pathologists
Co-authored papers 16
Lukas D Wartman
Washington University School of Medicine in St. Louis
Co-authored papers 16
Joshua F McMichael
Washington University
Co-authored papers 15
Malachi Griffith
Washington University
Co-authored papers 12
Lucinda Fulton
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 12
Michael C Wendl
Washington University in St Louis
Co-authored papers 12
Jason Walker
McDonnell Genome Institute, Washington University School of Medicine
Co-authored papers 11
Release 1.2