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Author Details

Christophe L M J Verlinde
University of Washington
1984
121
43
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
33753338Spontaneous Selection of <i>Cryptosporidium</i> Drug Resistance in a Calf Model of Infection.Antimicrob Agents Chemother2021
33479683Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against <i>Trypanosoma brucei</i>.RSC Med Chem2020
30745384Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection.Antimicrob Agents Chemother2019
29191253The calcium-dependent protein kinase 1 from Toxoplasma gondii as target for structure-based drug design.Parasitology2018
29633973The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate.Acta Crystallogr F Struct Biol Commun2018
28848016Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections.Antimicrob Agents Chemother2017
28465105Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors.Bioorg Med Chem Lett2017
28427904Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.Biochimie2017
276276285-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors.ACS Infect Dis2016
27788467Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.Eur J Med Chem2016
25163684Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening.J Biomol Screen2015
26249349A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.Acta Crystallogr D Biol Crystallogr2015
26324270Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites.Antimicrob Agents Chemother2015
24123773A specific inhibitor of PfCDPK4 blocks malaria transmission: chemical-genetic validation.J Infect Dis2014
24743796Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness.PLoS Negl Trop Dis2014
24531197Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes.Eur J Med Chem2014
24494061Potent and selective inhibitors of CDPK1 from <i>T. gondii</i> and <i>C. parvum</i> based on a 5-aminopyrazole-4-carboxamide scaffold.ACS Med Chem Lett2014
23587950Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target.Antimicrob Agents Chemother2013
24120539Dialkylimidazole inhibitors of Trypanosoma cruzi sterol 14α-demethylase as anti-Chagas disease agents.Bioorg Med Chem Lett2013
23831371The structure of the D3 domain of Plasmodium falciparum myosin tail interacting protein MTIP in complex with a nanobody.Mol Biochem Parasitol2013
23665145Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design.Mol Biochem Parasitol2013
22369268Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1.J Med Chem2012
22948920Structure of the prolyl-tRNA synthetase from the eukaryotic pathogen Giardia lamblia.Acta Crystallogr D Biol Crystallogr2012
22795629Benzoylbenzimidazole-based selective inhibitors targeting Cryptosporidium parvum and Toxoplasma gondii calcium-dependent protein kinase-1.Bioorg Med Chem Lett2012
22720744Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization.J Med Chem2012
22777048Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib.Antimicrob Agents Chemother2012
22902861Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection.Structure2012
22565309Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors.J Clin Invest2012
21282428Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice.Antimicrob Agents Chemother2011
21750879Screening a fragment cocktail library using ultrafiltration.Anal Bioanal Chem2011
21420975The double-length tyrosyl-tRNA synthetase from the eukaryote Leishmania major forms an intrinsically asymmetric pseudo-dimer.J Mol Biol2011
21144880Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate.Biochimie2011
21195115Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure-activity relationships with Trypanosoma brucei GSK-3.Mol Biochem Parasitol2011
21255615Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase.Mol Biochem Parasitol2011
20070944The crystal structure and activity of a putative trypanosomal nucleoside phosphorylase reveal it to be a homodimeric uridine phosphorylase.J Mol Biol2010
21116453Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii.ACS Med Chem Lett2010
20438846The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs.J Struct Biol2010
20132829Crystal structures of trypanosomal histidyl-tRNA synthetase illuminate differences between eukaryotic and prokaryotic homologs.J Mol Biol2010
20138091An internal sequence targets Trypanosoma brucei triosephosphate isomerase to glycosomes.Mol Biochem Parasitol2010
20347992Prediction of protein crystallization outcome using a hybrid method.J Struct Biol2010
20436472Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors.Nat Struct Mol Biol2010
20429511Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery.J Med Chem2010
19874856Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica.Mol Biochem Parasitol2010
19239254Rational modification of a candidate cancer drug for use against Chagas disease.J Med Chem2009
19929835Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium.Curr Top Med Chem2009
19463001Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease.J Med Chem2009
19470714Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands.J Biomol Screen2009
180771622-Oxo-tetrahydro-1,8-naphthyridines as selective inhibitors of malarial protein farnesyltransferase and as anti-malarials.Bioorg Med Chem Lett2008
18821750Evaluation of different virtual screening programs for docking in a charged binding pocket.J Chem Inf Model2008
18753195In vitro and in vivo properties of adenovirus vectors with increased affinity to CD46.J Virol2008
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Collaborators

Frederick S Buckner
University of Washington
Co-authored papers 53
Wesley C Van Voorhis
Center for Emerging and Re-emerging Infectious Diseases, University of Washington
Co-authored papers 44
Sayaka Shibata
Co-authored papers 14
Ximena Barros-??lvarez
Stanford University School of Medicine
Co-authored papers 6
Peter J Myler
University of Guelph
Co-authored papers 3
Thomas Earnest
Washington University School of Medicine in St. Louis
Co-authored papers 3
Elizabeth A Worthey
Heersink School of Medicine, The University of Alabama at Birmingham
Co-authored papers 3
Aaron Riechers
Co-authored papers 3
Brian E Krumm
University of North Carolina School of Medicine
Co-authored papers 2
Gregory J Crowther
Everett Community College
Co-authored papers 2
Ingeborg Feil
Howard Hughes Medical Institute, University of Washington
Co-authored papers 2
Christiane Hertz-Fowler
Institute of Integrative Biology, University of Liverpool
Co-authored papers 1
Maria A Doyle
Peter MacCallum Cancer Centre
Co-authored papers 1
Andrew L Hopkins
University of Dundee
Co-authored papers 1
Dong-Hui Chen
University of Washington School of Medicine
Co-authored papers 1
Artur V Cideciyan
Scheie Eye Institute, Perelman School of Medicine, University of Pennsylvania
Co-authored papers 1
David Baker
University of Washington
Co-authored papers 1
Matthew Berriman
Wellcome Sanger Institute
Co-authored papers 1
Gregg McAllister
Co-authored papers 1
Santiago J Carmona
AGORA Cancer Research Center
Co-authored papers 1
David L Veenstra
University of Washington
Co-authored papers 1
Ian M Carruthers
College of Life Sciences, University of Dundee
Co-authored papers 1
Zoran Brkanac
University of Washington
Co-authored papers 1
Douglas J LaCount
Purdue University
Co-authored papers 1
Feng Chen
Bayer Healthcare Pharmaceuticals
Co-authored papers 1
Stuart A Ralph
Bio21 Molecular Science and Biotechnology Institute, University of Melbourne
Co-authored papers 1
David S Roos
University of Pennsylvania
Co-authored papers 1
Patrick J Cimino
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Hediye Erdjument-Bromage
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Release 1.2