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Author Details

Emil Martin
The University of Texas-McGovern Medical School
1992
62
31
PMIDPaper TitleJournal TitlePublished Year
36766813Cellular Factors That Shape the Activity or Function of Nitric Oxide-Stimulated Soluble Guanylyl Cyclase.Cells2023
35197320ML355 Modulates Platelet Activation and Prevents ABT-737 Induced Apoptosis in Platelets.J Pharmacol Exp Ther2022
36304925Soluble guanylyl cyclase: Molecular basis for ligand selectivity and action <i>in vitro</i> and <i>in vivo</i>.Front Mol Biosci2022
35089807FoxO4 controls sGCβ transcription in vascular smooth muscle.Am J Physiol Heart Circ Physiol2022
33099233A new paradigm for gaseous ligand selectivity of hemoproteins highlighted by soluble guanylate cyclase.J Inorg Biochem2021
33571505Higher susceptibility to heme oxidation and lower protein stability of the rare α<sub>1</sub>C517Yβ<sub>1</sub> sGC variant associated with moyamoya syndrome.Biochem Pharmacol2021
33931865Involvement of 3',5'-cyclic inosine monophosphate in cystathionine γ-lyase-dependent regulation of the vascular tone.Br J Pharmacol2021
34408636Interaction and Subcellular Association of PRRT1/SynDIG4 With AMPA Receptors.Front Synaptic Neurosci2021
34365128Gemfibrozil derivatives as activators of soluble guanylyl cyclase - A structure-activity study.Eur J Med Chem2021
33349335A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations.Elife2020
33060787Homogeneous single-label cGMP detection platform for the functional study of nitric oxide-sensitive (soluble) guanylyl cyclases and cGMP-specific phosphodiesterases.Sci Rep2020
26972233The Role of Reactive Oxygen and Nitrogen Species in the Expression and Splicing of Nitric Oxide Receptor.Antioxid Redox Signal2017
28314778Stimulation of inducible nitric oxide by hepatitis B virus transactivator protein-HBx requires MTA1 coregulator.J Biol Chem2017
28584062Cytochrome b5 Reductase 3 Modulates Soluble Guanylate Cyclase Redox State and cGMP Signaling.Circ Res2017
26773124Stimulation of inducible nitric oxide by hepatitis B virus transactivator protein HBx requires MTA1 coregulator.J Biol Chem2016
27378567Regulation of soluble guanylyl cyclase redox state by hydrogen sulfide.Pharmacol Res2016
27515066Erythrocytes do not activate purified and platelet soluble guanylate cyclases even in conditions favourable for NO synthesis.Cell Commun Signal2016
26777256Disrupted nitric oxide signaling due to GUCY1A3 mutations increases risk for moyamoya disease, achalasia and hypertension.Clin Genet2016
25536881The fibrate gemfibrozil is a NO- and haem-independent activator of soluble guanylyl cyclase: in vitro studies.Br J Pharmacol2015
25044578Small alterations in cobinamide structure considerably influence sGC activation.ChemMedChem2014
25239802Alternative splicing impairs soluble guanylyl cyclase function in aortic aneurysm.Am J Physiol Heart Circ Physiol2014
23519483Protoporphyrin IX/Cobyrinate Derived Hybrids - Novel Activators of Soluble Guanylyl Cyclase.European J Org Chem2013
23961771Synthesis and evaluation of bifunctional sGC regulators: optimization of a connecting linker.J Med Chem2013
22111978A "sliding scale rule" for selectivity among NO, CO, and Oâ¿¿ by heme protein sensors.Biochemistry2012
24900497Synthesis of New Hydrophilic and Hydrophobic Cobinamides as NO-Independent sGC Activators.ACS Med Chem Lett2012
22991977Vitamin B⿁⿿ derivatives as activators of soluble guanylyl cyclase.J Med Chem2012
22690686The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase.Biochem J2012
22911749Hydrogen peroxide alters splicing of soluble guanylyl cyclase and selectively modulates expression of splicing regulators in human cancer cells.PLoS One2012
22570497Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation.Proc Natl Acad Sci U S A2012
22356101How do heme-protein sensors exclude oxygen? Lessons learned from cytochrome c', Nostoc puntiforme heme nitric oxide/oxygen-binding domain, and soluble guanylyl cyclase.Antioxid Redox Signal2012
22401134Mechanism of binding of NO to soluble guanylyl cyclase: implication for the second NO binding to the heme proximal site.Biochemistry2012
22171090Cobinamides are novel coactivators of nitric oxide receptor that target soluble guanylyl cyclase catalytic domain.J Pharmacol Exp Ther2012
20964618Nitric oxide receptor soluble guanylyl cyclase undergoes splicing regulation in differentiating human embryonic cells.Stem Cells Dev2011
22009742Dynamic ligand exchange in soluble guanylyl cyclase (sGC): implications for sGC regulation and desensitization.J Biol Chem2011
21867767RNA splicing in regulation of nitric oxide receptor soluble guanylyl cyclase.Nitric Oxide2011
21908708Restoring soluble guanylyl cyclase expression and function blocks the aggressive course of glioma.Mol Pharmacol2011
20022949Stimulation of inducible nitric oxide by hepatitis B virus transactivator protein HBx requires MTA1 coregulator.J Biol Chem2010
19948239Role of soluble guanylyl cyclase-cyclic GMP signaling in tumor cell proliferation.Nitric Oxide2010
19089322A short history of cGMP, guanylyl cyclases, and cGMP-dependent protein kinases.Handb Exp Pharmacol2009
19596685Kinetic and cellular characterization of novel inhibitors of S-nitrosoglutathione reductase.J Biol Chem2009
18381288Alpha1 soluble guanylyl cyclase (sGC) splice forms as potential regulators of human sGC activity.J Biol Chem2008
18048340Dynamic interplay between nitration and phosphorylation of tubulin cofactor B in the control of microtubule dynamics.Proc Natl Acad Sci U S A2007
16864588Ligand selectivity of soluble guanylyl cyclase: effect of the hydrogen-bonding tyrosine in the distal heme pocket on binding of oxygen, nitric oxide, and carbon monoxide.J Biol Chem2006
15796527Resonance Raman and infrared spectroscopic studies of high-output forms of human soluble guanylyl cyclase.J Am Chem Soc2005
16291255Soluble guanylyl cyclase: the nitric oxide receptor.Methods Enzymol2005
14684830Guanylyl cyclase is an ATP sensor coupling nitric oxide signaling to cell metabolism.Proc Natl Acad Sci U S A2004
15347653CCTeta, a novel soluble guanylyl cyclase-interacting protein.J Biol Chem2004
12719531Histone H1.2 is a substrate for denitrase, an activity that reduces nitrotyrosine immunoreactivity in proteins.Proc Natl Acad Sci U S A2003
14504408CCAAT-binding factor regulates expression of the beta1 subunit of soluble guanylyl cyclase gene in the BE2 human neuroblastoma cell line.Proc Natl Acad Sci U S A2003
12883009A constitutively activated mutant of human soluble guanylyl cyclase (sGC): implication for the mechanism of sGC activation.Proc Natl Acad Sci U S A2003
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Collaborators

George Washington University
Co-authored papers 26
National Research Center for Preventive Medicine (NRCPM)
Co-authored papers 5
Rutgers New Jersey Medical School
Co-authored papers 4
University of Science and Technology of China
Co-authored papers 3
Institute of Molecular Medicine, University of Texas-Houston Health Science Center
Co-authored papers 2
The University of Texas MD Anderson Cancer Center Houston
Co-authored papers 2
Baylor College of Medicine
Co-authored papers 2
Co-authored papers 2
Great Ormond Street Hospital for Children NHS Foundation Trust
Co-authored papers 1
the Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Co-authored papers 1
The University of Texas M.D. Anderson Cancer Center
Co-authored papers 1
University of Washington
Co-authored papers 1
Co-authored papers 1
Charles E. Schmidt College of Medicine, Florida Atlantic University
Co-authored papers 1
American Association for Cancer Research, Henry Ford Hospital, Ludwig Institute for Cancer Research, National Cancer Institute, Salk Institute for Biological Studies, University of Cambridge, University of Texas MD Anderson Cancer Center, Virginia Commonwealth University
Co-authored papers 1
University of Maryland School of Medicine
Co-authored papers 1
University of Washington
Co-authored papers 1
The University of Texas MD Anderson Cancer Center
Co-authored papers 1
Columbia University Irving Medical Center
Co-authored papers 1
Baylor College of Medicine
Co-authored papers 1
Baylor College of Medicine.
Co-authored papers 1
University of Texas Medical School
Co-authored papers 1
The University of Texas M, Anderson Cancer Center
Co-authored papers 1