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Author Details

Dinshaw J Patel
Memorial Sloan-Kettering Cancer Center
1969
539
119
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37932446Fanzors: Striking expansion of RNA-guided endonucleases to eukaryotes.Cell Res2024
36109597A structural platform for B cell receptor signaling.Cell Res2023
37961437Cryo-EM structure of the Spo11 core complex bound to DNA.bioRxiv2023
37903273Molecular basis for Nse5-6 mediated regulation of Smc5/6 functions.Proc Natl Acad Sci U S A2023
37536341Arabinose- and xylose-modified analogs of 2',3'-cGAMP act as STING agonists.Cell Chem Biol2023
37147228Structure-based mechanisms of 2'3'-cGAMP intercellular transport in the cGAS-STING immune pathway.Trends Immunol2023
36588116A 'warhorse-shaped' topology adopted by the m<sup>6</sup>A RNA writer complex.Cell Res2023
36894694cGAMP-activated cGAS-STING signaling: its bacterial origins and evolutionary adaptation by metazoans.Nat Struct Mol Biol2023
34111237The Effect of Neutropenia and Filgrastim (G-CSF) on Cancer Patients With Coronavirus Disease 2019 (COVID-19) Infection.Clin Infect Dis2022
35648833Cryo-EM structure of DNA-bound Smc5/6 reveals DNA clamping enabled by multi-subunit conformational changes.Proc Natl Acad Sci U S A2022
36460008Bacterial origins of cyclic nucleotide-activated antiviral immune signaling.Mol Cell2022
36280711A type III-E CRISPR Craspase exhibiting RNase and protease activities.Cell Res2022
35931820Structure-based evolutionary relationship between IscB and Cas9.Cell Res2022
36323770Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells.Sci Rep2022
36050374Cofactor-assisted dicing: insights from structural snapshots.Cell Res2022
35144965Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins.Genes Dev2022
35087229The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites.Nat Microbiol2022
35202575Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance.Mol Cell2022
35173350Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery.Nat Struct Mol Biol2022
34967418Structure-activity relationships at a nucleobase-stacking tryptophan required for chemomechanical coupling in the DNA resecting motor-nuclease AdnAB.Nucleic Acids Res2022
35136229Publisher Correction: The transcriptional regulator HDP1 controls expansion of the inner membrane complex during early sexual differentiation of malaria parasites.Nat Microbiol2022
35194144Combination of antiviral drugs inhibits SARS-CoV-2 polymerase and exonuclease and demonstrates COVID-19 therapeutic potential in viral cell culture.Commun Biol2022
34808193Ceramide-1-phosphate transfer protein promotes sphingolipid reorientation needed for binding during membrane interaction.J Lipid Res2022
33472057Structural basis for self-cleavage prevention by tag:anti-tag pairing complementarity in type VI Cas13 CRISPR systems.Mol Cell2021
33744958Oligomeric quaternary structure of Escherichia coli and Mycobacterium smegmatis Lhr helicases is nucleated by a novel C-terminal domain composed of five winged-helix modules.Nucleic Acids Res2021
33574069Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex.Genes Dev2021
33880524In vitro antiviral activity of the anti-HCV drugs daclatasvir and sofosbuvir against SARS-CoV-2, the aetiological agent of COVID-19.J Antimicrob Chemother2021
33597306Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex.Proc Natl Acad Sci U S A2021
33739344Penicillin Allergy Testing: An Outpatient Nurse-Driven Program for Patients With Cancer.Clin J Oncol Nurs2021
33731927DNA-driven condensation assembles the meiotic DNA break machinery.Nature2021
33781749Ceramide-1-phosphate transfer protein (CPTP) regulation by phosphoinositides.J Biol Chem2021
33857403DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network.Mol Cell2021
34843431Correction: Structural basis of phosphatidylcholine recognition by the C2-Domain of cytosolic phospholipase A<sub>2</sub>α.Elife2021
33941775DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation.Nat Commun2021
33941673Integrative analysis reveals unique structural and functional features of the Smc5/6 complex.Proc Natl Acad Sci U S A2021
34210982Binding of guide piRNA triggers methylation of the unstructured N-terminal region of Aub leading to assembly of the piRNA amplification complex.Nat Commun2021
34089013Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins.Nat Rev Mol Cell Biol2021
34312622Combination of Antiviral Drugs to Inhibit SARS-CoV-2 Polymerase and Exonuclease as Potential COVID-19 Therapeutics.bioRxiv2021
34048709N<sup>6</sup>-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.Cancer Cell2021
33461211The Card1 nuclease provides defence during type III CRISPR immunity.Nature2021
33361816Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.Nature2021
32371455RNA-Puzzles Round IV: 3D structure predictions of four ribozymes and two aptamers.RNA2020
31925391Structure-function insights into the initial step of DNA integration by a CRISPR-Cas-Transposon complex.Cell Res2020
31804735Crucial Roles of Two Hydrated Mg<sup>2+</sup> Ions in Reaction Catalysis of the Pistol Ribozyme.Angew Chem Int Ed Engl2020
33199607Structure-function analysis of microRNA 3'-end trimming by Nibbler.Proc Natl Acad Sci U S A2020
33057135Keeping innate immune response in check: when cGAS meets the nucleosome.Cell Res2020
32817981The Effect of Neutropenia and Filgrastim (G-CSF) in Cancer Patients With COVID-19 Infection.medRxiv2020
32675241Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation.Proc Natl Acad Sci U S A2020
32419212Granulocyte-colony stimulating factor in COVID-19: Is it stimulating more than just the bone marrow?Am J Hematol2020
32187176Modeling cancer genomic data in yeast reveals selection against ATM function during tumorigenesis.PLoS Genet2020
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Collaborators

C David Allis
The Rockefeller University
Co-authored papers 16
Lawrence Shapiro
Zuckerman Mind Brain Behaviour Institute
Co-authored papers 14
David Live
Co-authored papers 9
Jian Feng
Co-authored papers 8
Or Gozani
Stanford University
Co-authored papers 8
Brian D Strahl
University of North Carolina
Co-authored papers 5
Alexei A Aravin
Co-authored papers 5
Ajay A Vashisht
David Geffen School of Medicine, University of California los angeles
Co-authored papers 4
James A Wohlschlegel
David Geffen School of Medicine, University of California Los Angeles
Co-authored papers 4
Julius Brennecke
Co-authored papers 4
Martin Karplus
Harvard University
Co-authored papers 4
Mallika Sastry
Co-authored papers 4
Robert B Darnell
Co-authored papers 3
Nikolay V Dokholyan
Pennsylvania State University College of Medicine
Co-authored papers 3
Katalin Fejes Tóth
Co-authored papers 3
Qi Dai
Co-authored papers 3
Ari Melnick
Co-authored papers 3
Scott Dewell
Co-authored papers 3
Xiaolan Zhao
Memorial Sloan-Kettering Cancer Center
Co-authored papers 3
Shibai Li
Memorial Sloan-Kettering Cancer Center
Co-authored papers 3
Rhiju Das
Stanford University School of Medicine
Co-authored papers 3
Michael Jason de la Cruz
Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center
Co-authored papers 3
Eric C Lai
Co-authored papers 3
Karl Mechtler
IMP-Institute of Molecular Pathology
Co-authored papers 2
Alex J Kuo
Co-authored papers 2
Fang Fang
Co-authored papers 2
Matteo Pellegrini
Co-authored papers 2
Brian T Chait
The Rockefeller University
Co-authored papers 2
Pamela J Thomas
Co-authored papers 2
Kyle M Miller
The University of Texas at Austin
Co-authored papers 2
Release 1.2