Author details

Full Name

Paul G Ekert

Affiliation

ORCID

Career Start Year

1988

Papers

139

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37523146	High-Throughput Drug Screening of Primary Tumor Cells Identifies Therapeutic Strategies for Treating Children with High-Risk Cancer.	Cancer Res	2023
36179268	Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions.	Blood	2023
37767021	Toblerone: detecting exon deletion events in cancer using RNA-seq.		2023
37018415	T-like CAR-T cells exhibit improved persistence and tumor control compared with conventional CAR-T cells in preclinical models.		2023
37013636	A novel transcriptional signature identifies T-cell infiltration in high-risk paediatric cancer.	Genome Med	2023
36882456	Histone H3-wild type diffuse midline gliomas with H3K27me3 loss are a distinct entity with exclusive EGFR or ACVR1 mutation and differential methylation of homeobox genes.	Sci Rep	2023
37130917	Biological and clinical implications of FGFR aberrations in paediatric and young adult cancers.		2023
36810896	Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL.	Leukemia	2023
37191437	Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia.	Cancer Discov	2023
37001527	Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities.	Cancer Cell	2023
36937401	<i>In vivo</i> loss of tumorigenicity in a patient-derived orthotopic xenograft mouse model of ependymoma.	Front Oncol	2023
37106113	Harnessing immune checkpoint trial data in pediatric cancer.		2023
34471258	Whole-genome sequencing facilitates patient-specific quantitative PCR-based minimal residual disease monitoring in acute lymphoblastic leukaemia, neuroblastoma and Ewing sarcoma.	Br J Cancer	2022
35443029	Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia.	Blood	2022
35482550	ALLSorts: an RNA-Seq subtype classifier for B-cell acute lymphoblastic leukemia.	Blood advances	2022
36505819	Advances in CAR T cell immunotherapy for paediatric brain tumours.	Front Oncol	2022
34991664	JAFFAL: detecting fusion genes with long-read transcriptome sequencing.		2022
35061886	SFPQ-ABL1 and BCR-ABL1 use different signaling networks to drive B-cell acute lymphoblastic leukemia.	Blood Adv	2022
35192684	Enhancer retargeting of CDX2 and UBTF::ATXN7L3 define a subtype of high-risk B-progenitor acute lymphoblastic leukemia.	Blood	2022
34944614	Enhancing the Potential of Immunotherapy in Paediatric Sarcomas: Breaking the Immunosuppressive Barrier with Receptor Tyrosine Kinase Inhibitors.	Biomedicines	2021
33580196	Efficacy of MEK inhibition in a recurrent malignant peripheral nerve sheath tumor.	NPJ Precis Oncol	2021
34257311	Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance.	Nat Commun	2021
34686194	MINTIE: identifying novel structural and splice variants in transcriptomes using RNA-seq data.		2021
34572932	Chimeric Antigen Receptor T cell Therapy and the Immunosuppressive Tumor Microenvironment in Pediatric Sarcoma.	Cancers (Basel)	2021
34792574	Cycling without brakes lets ALL escape.	Blood	2021
35035899	Slinker: Visualising novel splicing events in RNA-Seq data.	F1000Research	2021
34390800	Precision medicine and phosphoproteomics for the identification of novel targeted therapeutic avenues in sarcomas.		2021
34493325	Diffuse leptomeningeal glioneuronal tumour (DLGNT) in children: the emerging role of genomic analysis.	Acta neuropathologica communications	2021
34375680	Early-phenotype CAR-T cells for the treatment of pediatric cancers.	Ann Oncol	2021
33053751	A Novel Orthotopic Patient-Derived Xenograft Model of Radiation-Induced Glioma Following Medulloblastoma.	Cancers (Basel)	2020
32150610	The application of RNA sequencing for the diagnosis and genomic classification of pediatric acute lymphoblastic leukemia.	Blood advances	2020
33259802	Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis.	Cell	2020
32538896	Immune profiling of pediatric solid tumors.	J Clin Invest	2020
33144287	Recurrent <i>SPECC1L-NTRK</i> fusions in pediatric sarcoma and brain tumors.	Cold Spring Harb Mol Case Stud	2020
33035331	MLL-TFE3: a novel and aggressive KMT2A fusion identified in infant leukemia.	Blood Adv	2020
32569380	Cotargeting BCL-2 and MCL-1 in high-risk B-ALL.	Blood Adv	2020
31250523	Targeted therapy and disease monitoring in CNTRL-FGFR1-driven leukaemia.	Pediatric Blood and Cancer	2019
30429576	Author Correction: Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome.	Nat Genet	2019
30899083	Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL-USP2 fusions.	Leukemia	2019
29601851	MicroRNA-155 expression and function in AML: An evolving paradigm.	Experimental Hematology	2018
28716883	Role of the Î² Common (Î²c) Family of Cytokines in Health and Disease.	Cold Spring Harbor perspectives in biology	2018
28751770	Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1.	Leukemia	2018
29982439	Clinker: visualizing fusion genes detected in RNA-seq data.	GigaScience	2018
30220707	Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma.	Br J Cancer	2018
30299205	Integration of genomics, high throughput drug screening, and personalized xenograft models as a novel precision medicine paradigm for high risk pediatric cancer.	Cancer Biol Ther	2018
30374066	Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome.	Nat Genet	2018
29939160	Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma.	J Clin Invest	2018
29607586	Exploring the feasibility and utility of exome-scale tumour sequencing in a clinical setting.	Intern Med J	2018
28120432	Genetic determinants of anthracycline cardiotoxicity - ready for the clinic?	British Journal of Clinical Pharmacology	2017
28717011	Dysregulation of BCL-2 family proteins by leukemia fusion genes.	Journal of Biological Chemistry	2017