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Author Details

Fred van Leeuwen
Netherlands Cancer Institute, University of Amsterdam
1983
83
34
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37127821Dynamic epistasis analysis reveals how chromatin remodeling regulates transcriptional bursting.Nat Struct Mol Biol2023
37995691Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA polymerase III assembly.Mol Cell2023
37099396DOT1L regulates chromatin reorganization and gene expression during sperm differentiation.EMBO Rep2023
35103966Epi-Decoder: Decoding the Local Proteome of a Genomic Locus by Massive Parallel Chromatin Immunoprecipitation Combined with DNA-Barcode Sequencing.Methods Mol Biol2022
35661267SETD2: from chromatin modifier to multipronged regulator of the genome and beyond.Cell Mol Life Sci2022
36425063DOT1L inhibition does not modify the sensitivity of cutaneous T cell lymphoma to pan-HDAC inhibitors <i>in vitro</i>.Front Genet2022
36417856DOT1L regulates lipid biosynthesis and inflammatory responses in macrophages and promotes atherosclerotic plaque stability.Cell Rep2022
36052643The histone methyltransferase SETD2 negatively regulates cell size.J Cell Sci2022
34140538Epigenetics Identifier screens reveal regulators of chromatin acylation and limited specificity of acylation antibodies.Sci Rep2021
34398252Signals for antigen-independent differentiation of memory CD8<sup>+</sup> T cells.Cell Mol Life Sci2021
32228348Application of Recombination -Induced Tag Exchange (RITE) to study histone dynamics in human cells.Epigenetics2020
32764145The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8<sup>+</sup> T cells.Proc Natl Acad Sci U S A2020
32188699Inhibition of transcription leads to rewiring of locus-specific chromatin proteomes.Genome Res2020
32154221Strategy for Development of Site-Specific Ubiquitin Antibodies.Front Chem2020
32299836A genetic interaction map centered on cohesin reveals auxiliary factors involved in sister chromatid cohesion in <i>S. cerevisiae</i>.J Cell Sci2020
31304633Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma.EMBO J2019
31797935CD4<sup>+</sup> T cell help creates memory CD8<sup>+</sup> T cells with innate and help-independent recall capacities.Nat Commun2019
31524790A novel germline variant in the DOT1L gene co-segregating in a Dutch family with a history of melanoma.Melanoma Res2019
31602606Epi-ID: Systematic and Direct Screening for Chromatin Regulators in Yeast by Barcode-ChIP-Seq.Methods Mol Biol2019
29258884Drug toxicity profiling of a Saccharomyces cerevisiae deubiquitinase deletion panel shows that acetaminophen mimics tyrosine.Toxicol In Vitro2018
30203048Dot1 promotes H2B ubiquitination by a methyltransferase-independent mechanism.Nucleic Acids Res2018
30005073Decoding the chromatin proteome of a single genomic locus by DNA sequencing.PLoS Biol2018
28291796The effect of acetaminophen on ubiquitin homeostasis in Saccharomyces cerevisiae.PLoS One2017
26728620The upstreams and downstreams of H3K79 methylation by DOT1L.Chromosoma2016
27922451Direct screening for chromatin status on DNA barcodes in yeast delineates the regulome of H3K79 methylation by Dot1.Elife2016
25533186Yeast PP4 interacts with ATR homolog Ddc2-Mec1 and regulates checkpoint signaling.Mol Cell2015
25965993Dot1 histone methyltransferases share a distributive mechanism but have highly diverged catalytic properties.Sci Rep2015
25413350N-terminal acetylation and replicative age affect proteasome localization and cell fitness during aging.J Cell Sci2015
24854991The emerging roles of DOT1L in leukemia and normal development.Leukemia2014
25141862Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo.EMBO Rep2014
23248297Spatiotemporal analysis of organelle and macromolecular complex inheritance.Proc Natl Acad Sci U S A2013
24360959A UV-induced genetic network links the RSC complex to nucleotide excision repair and shows dose-dependent rewiring.Cell Rep2013
23708297Recombination-induced tag exchange (RITE) cassette series to monitor protein dynamics in Saccharomyces cerevisiae.G3 (Bethesda)2013
23438860A network model of the molecular organization of chromatin in Drosophila.Mol Cell2013
23382701Dot1-dependent histone H3K79 methylation promotes activation of the Mek1 meiotic checkpoint effector kinase by regulating the Hop1 adaptor.PLoS Genet2013
22157090News about old histones: a role for histone age in controlling the epigenome.Cell Cycle2012
22807688A key role for Chd1 in histone H3 dynamics at the 3' ends of long genes in yeast.PLoS Genet2012
22820947An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks.EMBO J2012
22332652Crosstalk between aging and the epigenome.Epigenomics2012
21243718A modified epigenetics toolbox to study histone modifications on the nucleosome core.Chembiochem2011
21998594A barcode screen for epigenetic regulators reveals a role for the NuB4/HAT-B histone acetyltransferase complex in histone turnover.PLoS Genet2011
21760613Progressive methylation of ageing histones by Dot1 functions as a timer.EMBO Rep2011
21666805Patterns and mechanisms of ancestral histone protein inheritance in budding yeast.PLoS Biol2011
21291527Dot1 binding induces chromatin rearrangements by histone methylation-dependent and -independent mechanisms.Epigenetics Chromatin2011
20018668Recombination-induced tag exchange to track old and new proteins.Proc Natl Acad Sci U S A2010
21084562Heterologous expression reveals distinct enzymatic activities of two DOT1 histone methyltransferases of Trypanosoma brucei.J Cell Sci2010
19217406Reconstitution of yeast silent chromatin: multiple contact sites and O-AADPR binding load SIR complexes onto nucleosomes in vitro.Mol Cell2009
19638198Multiple histone modifications in euchromatin promote heterochromatin formation by redundant mechanisms in Saccharomyces cerevisiae.BMC Mol Biol2009
19778927Two Dot1 isoforms in Saccharomyces cerevisiae as a result of leaky scanning by the ribosome.Nucleic Acids Res2009
19273586Mutational analysis of the Sir3 BAH domain reveals multiple points of interaction with nucleosomes.Mol Cell Biol2009
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Collaborators

Tibor van Welsem
Netherlands Cancer Institute
Co-authored papers 26
Hanneke Vlaming
Blavatnik Institute, Harvard Medical School
Co-authored papers 11
Tessy Korthout
Oncode Institute
Co-authored papers 7
Huib Ovaa
Leiden University Medical Center
Co-authored papers 6
Thom M Molenaar
Amsterdam UMC location Vrije Universiteit Amsterdam
Co-authored papers 6
Haico van Attikum
Leiden University Medical Center
Co-authored papers 6
Iris J E Stulemeijer
Netherlands Cancer Institute
Co-authored papers 6
Deepani W Poramba-Liyanage
Utrecht University Utrecht The Netherlands.
Co-authored papers 5
Tineke L Lenstra
the Netherlands Cancer Institute, Oncode Institute
Co-authored papers 5
Susan M Gasser
L'Institut Suisse de Recherche Experimentale sur le Cancer (ISREC) Foundation
Co-authored papers 4
Trey Ideker (CM4AI)
University of California San Diego
Co-authored papers 4
Albert J R Heck
Utrecht University
Co-authored papers 3
Frank C P Holstege
Princess Maxima Center for Pediatric Oncology
Co-authored papers 3
Rohith Srivas
Amgen Inc.
Co-authored papers 3
Bas van Steensel
Oncode Institute, Netherlands Cancer Institute
Co-authored papers 2
Su Ming Sun
Leiden University Medical Center
Co-authored papers 2
Monika Tsai-Pflugfelder
Friedrich Miescher Institute for Biomedical Research
Co-authored papers 2
David M MacAlpine
Co-authored papers 2
Oliver J Rando
University of Massachusetts Chan Medical School
Co-authored papers 2
Farid El Oualid
The Netherlands Cancer Institute
Co-authored papers 2
Nicole Hustedt
Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
Co-authored papers 2
Kirsten van Harten
Netherlands Cancer Institute
Co-authored papers 2
Aude Gu??nol??
CNRS, Universite de Toulouse
Co-authored papers 2
Kenji Shimada
Friedrich Miescher Institute for Biomedical Research
Co-authored papers 2
Philip J Robinson
College of Medical Veterinary and Life Sciences, University of Glasgow
Co-authored papers 1
Sovan Sarkar
CRUK MRC Oxford Institute for Radiation Oncology, University of Oxford
Co-authored papers 1
Marijke Pool
Leiden University Medical Center
Co-authored papers 1
Tesa M Severson
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