Author details

Full Name

Jun Xu

Affiliation

ORCID

Career Start Year

2014

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36690613	Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor.		2023
35022237	RNA polymerase II trapped on a molecular treadmill: Structural basis of persistent transcriptional arrest by a minor groove DNA binder.	Proceedings of the National Academy of Sciences of the United States of America	2022
35273076	NDF is a transcription factor that stimulates elongation by RNA polymerase II.	Genes Dev	2022
34853308	Mechanism of Rad26-assisted rescue of stalled RNA polymerase II in transcription-coupled repair.	Nat Commun	2021
33536256	FATC Domain Deletion Compromises ATM Protein Stability, Blocks Lymphocyte Development, and Promotes Lymphomagenesis.	Journal of Immunology	2021
33877330	Opposite roles of transcription elongation factors Spt4/5 and Elf1 in RNA polymerase II transcription through B-form versus non-B DNA structures.	Nucleic Acids Research	2021
34197619	Strand-specific effect of Rad26 and TFIIS in rescuing transcriptional arrest by CAG trinucleotide repeat slip-outs.	Nucleic Acids Research	2021
34140682	Transcriptional processing of an unnatural base pair by eukaryotic RNA polymerase II.	Nat Chem Biol	2021
33239428	The Cancer-Associated ATM R3008H Mutation Reveals the Link between ATM Activation and Its Exchange.	Cancer Res	2021
33271312	Molecular basis of transcriptional pausing, stalling, and transcription-coupled repair initiation.	Biochimica et Biophysica Acta - Gene Regulatory Mechanisms	2021
32572026	Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family.	Nature Communications	2020
32284409	RNA polymerase II stalls on oxidative DNA damage via a torsion-latch mechanism involving lone pair-Ï¿ and CH-Ï¿ interactions.	Proceedings of the National Academy of Sciences of the United States of America	2020
31988135	RNA sequencing by direct tagmentation of RNA/DNA hybrids.	Proceedings of the National Academy of Sciences of the United States of America	2020
32152538	Activation of the Î± adrenoceptor by the sedative sympatholytic dexmedetomidine.	Nature Chemical Biology	2020
32989164	Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps RNA polymerase II overcome nucleosome barriers.	Proc Natl Acad Sci U S A	2020
32868434	Analysis of Î²AR-G and Î²AR-G complex formation by NMR spectroscopy.	Proceedings of the National Academy of Sciences of the United States of America	2020
31103421	Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by NMR Spectroscopy.	Molecular Cell	2019
31179024	Intrinsic Cleavage of RNA Polymerase II Adopts a Nucleobase-independent Mechanism Assisted by Transcript Phosphate.	Nat Energy	2019
30867290	Molecular basis of chromatin remodeling by Rhp26, a yeast CSB ortholog.	Proc Natl Acad Sci U S A	2019
30797902	Structural and biochemical analysis of DNA lesion-induced RNA polymerase II arrest.	Methods	2019
31200019	3.1 Ã¿ structure of yeast RNA polymerase II elongation complex stalled at a cyclobutane pyrimidine dimer lesion solved using streptavidin affinity grids.	J Struct Biol	2019
29453275	Structure-based discovery of selective positive allosteric modulators of antagonists for the M<sub>2</sub> muscarinic acetylcholine receptor.	Proc Natl Acad Sci U S A	2018
30174298	Structural basis of DNA lesion recognition for eukaryotic transcription-coupled nucleotide excision repair.	DNA Repair (Amst)	2018
30127008	Structural basis of RNA polymerase I stalling at UV light-induced DNA damage.	Proceedings of the National Academy of Sciences of the United States of America	2018
29168508	Structural basis for the initiation of eukaryotic transcription-coupled DNA repair.	Nature	2017
26392149	RNA polymerase II transcriptional fidelity control and its functional interplay with DNA modifications.	Crit Rev Biochem Mol Biol	2015
25074911	Strand-specific (asymmetric) contribution of phosphodiester linkages on RNA polymerase II transcriptional efficiency and fidelity.	Proceedings of the National Academy of Sciences of the United States of America	2014
25159856	Pyrene-based quantitative detection of the 5-formylcytosine loci symmetry in the CpG duplex content during TET-dependent demethylation.	Angewandte Chemie - International Edition	2014