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Author Details

Michael Emerman
Fred Hutchinson Cancer Center
1982
151
67
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36700640Virology under the Microscope-a Call for Rational Discourse.J Virol2023
37546973A CRISPR screen of HIV dependency factors reveals <i>CCNT1</i> is non-essential in T cells but required for HIV-1 reactivation from latency.bioRxiv2023
37608289Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor.Retrovirology2023
37766271A CRISPR Screen of HIV Dependency Factors Reveals That CCNT1 Is Non-Essential in T Cells but Required for HIV-1 Reactivation from Latency.Viruses2023
36993223Primate TRIM34 is a broadly-acting, TRIM5-dependent lentiviral restriction factor.bioRxiv2023
37417868A human-specific motif facilitates CARD8 inflammasome activation after HIV-1 infection.Elife2023
36754086The structural basis for HIV-1 Vif antagonism of human APOBEC3G.Nature2023
36744886A Virus-Packageable CRISPR System Identifies Host Dependency Factors Co-Opted by Multiple HIV-1 Strains.mBio2023
36706161A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency.PLoS Pathog2023
36700653Virology under the Microscope-a Call for Rational Discourse.mSphere2023
36700642Virology under the Microscope-a Call for Rational Discourse.mBio2023
35080919Evolutionary Landscapes of Host-Virus Arms Races.Annu Rev Immunol2022
34908448HIV-1 Vif Gained Breadth in APOBEC3G Specificity after Cross-Species Transmission of Its Precursors.J Virol2022
34170969Highly-potent, synthetic APOBEC3s restrict HIV-1 through deamination-independent mechanisms.PLoS Pathog2021
34666043Divergence in Dimerization and Activity of Primate APOBEC3C.J Mol Biol2021
32479260Retrocopying expands the functional repertoire of APOBEC3 antiviral proteins in primates.Elife2020
32930662Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races.Elife2020
32282853TRIM34 restricts HIV-1 and SIV capsids in a TRIM5α-dependent manner.PLoS Pathog2020
32353859A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.Nature2020
32235597Polymorphisms in Human APOBEC3H Differentially Regulate Ubiquitination and Antiviral Activity.Viruses2020
32345636APOBEC3C Tandem Domain Proteins Create Super Restriction Factors against HIV-1.mBio2020
31574080Combinatorial mutagenesis of rapidly evolving residues yields super-restrictor antiviral proteins.PLoS Biol2019
31830442Structural Basis for a Species-Specific Determinant of an SIV Vif Protein toward Hominid APOBEC3G Antagonism.Cell Host Microbe2019
31260493Macaque interferon-induced transmembrane proteins limit replication of SHIV strains in an Envelope-dependent manner.PLoS Pathog2019
29554922A CRISPR screen for factors regulating SAMHD1 degradation identifies IFITMs as potent inhibitors of lentiviral particle delivery.Retrovirology2018
29925657Recurrent Loss of APOBEC3H Activity during Primate Evolution.J Virol2018
30520725A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV.Elife2018
28158858Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization.Nucleic Acids Res2017
28228523Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.Proc Natl Acad Sci U S A2017
27189538Conservation and Innovation of APOBEC3A Restriction Functions during Primate Evolution.Mol Biol Evol2016
27732658A Single Nucleotide Polymorphism in Human APOBEC3C Enhances Restriction of Lentiviruses.PLoS Pathog2016
27624129Activation of the DNA Damage Response Is a Conserved Function of HIV-1 and HIV-2 Vpr That Is Independent of SLX4 Recruitment.mBio2016
26394054The Role of the Antiviral APOBEC3 Gene Family in Protecting Chimpanzees against Lentiviruses from Monkeys.PLoS Pathog2015
26658285Evolutionary Analyses Suggest a Function of MxB Immunity Proteins Beyond Lentivirus Restriction.PLoS Pathog2015
24586139A novel Bayesian method for detection of APOBEC3-mediated hypermutation and its application to zoonotic transmission of simian foamy viruses.PLoS Comput Biol2014
25411794Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity.PLoS Genet2014
23359341Convergence and divergence in the evolution of the APOBEC3G-Vif interaction reveal ancient origins of simian immunodeficiency viruses.PLoS Pathog2013
24324150Antagonism of SAMHD1 is actively maintained in natural infections of simian immunodeficiency virus.Proc Natl Acad Sci U S A2013
24158625An evolutionary screen highlights canonical and noncanonical candidate antiviral genes within the primate TRIM gene family.Genome Biol Evol2013
23874202Evolutionary toggling of Vpx/Vpr specificity results in divergent recognition of the restriction factor SAMHD1.PLoS Pathog2013
23870316Gene loss and adaptation to hominids underlie the ancient origin of HIV-1.Cell Host Microbe2013
23938749Host gene evolution traces the evolutionary history of ancient primate lentiviruses.Philos Trans R Soc Lond B Biol Sci2013
24013523The mongoose, the pheasant, the pox, and the retrovirus.PLoS Biol2013
23755966Identification and antiviral activity of common polymorphisms in the APOBEC3 locus in human populations.Virology2013
23725670An evolutionary perspective on the broad antiviral specificity of MxA.Curr Opin Microbiol2013
23319649Birth, decay, and reconstruction of an ancient TRIMCyp gene fusion in primate genomes.Proc Natl Acad Sci U S A2013
22264516The host restriction factor APOBEC3G and retroviral Vif protein coevolve due to ongoing genetic conflict.Cell Host Microbe2012
22976433Evolutionary conflicts between viruses and restriction factors shape immunity.Nat Rev Immunol2012
23084925Evolution-guided identification of antiviral specificity determinants in the broadly acting interferon-induced innate immunity factor MxA.Cell Host Microbe2012
22734835The function and evolution of the restriction factor Viperin in primates was not driven by lentiviruses.Retrovirology2012
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Collaborators

Harmit S Malik
Fred Hutchinson Cancer Center
Co-authored papers 28
Beatrice H Hahn
Co-authored papers 6
Marco Vignuzzi
Quantitative Biosciences Institute (QBI) Coronavirus Research Group (QCRG)
Co-authored papers 4
Adolfo Garc??a-Sastre
Icahn School of Medicine at Mount Sinai
Co-authored papers 4
Nicholas M Chesarino
Fred Hutchinson Cancer Center
Co-authored papers 4
Linda Chelico
University of Saskatchewan, College of Medicine
Co-authored papers 4
Shari M Kaiser
Seattle Biomedical Research Institute
Co-authored papers 4
Patrizia Caposio
Vaccine and Gene Therapy Institute, Oregon Health & Science University
Co-authored papers 3
Stephen P Goff
Columbia University
Co-authored papers 3
Balaji Manicassamy
University of Iowa
Co-authored papers 3
Ana Fernandez-Sesma
Icahn School of Medicine at Mount Sinai
Co-authored papers 3
Janet M Young
Fred Hutchinson Cancer Research Center
Co-authored papers 3
Ferdinand Roesch
VA-MD Regional College of Veterinary Medicine, Virginia Tech
Co-authored papers 3
Jay A Nelson
Oregon Health and Science University
Co-authored papers 3
Wesley I Sundquist
University of Utah School of Medicine
Co-authored papers 3
Nels C Elde
University of Utah School of Medicine
Co-authored papers 3
Andrew D Yurochko
Louisiana State University
Co-authored papers 3
Rolf Renne
Co-authored papers 3
Adam S Lauring
University of Michigan ann arbor
Co-authored papers 3
Nicholas S Heaton
Duke University School of Medicine
Co-authored papers 3
Meaghan H Hancock
Vaccine and Gene Therapy Institute, Oregon Health & Science University
Co-authored papers 3
Benhur Lee
Icahn School of Medicine at Mount Sinai
Co-authored papers 3
Adrianus C M Boon
Co-authored papers 3
Charles M Rice
Rockefeller University
Co-authored papers 3
Matthew D Weitzman
The Children's Hospital of Philadelphia
Co-authored papers 3
Mark T Heise
University of North Carolina at Chapel Hill.
Co-authored papers 3
Arturo Casadevall
Johns Hopkins Bloomberg School of Public Health
Co-authored papers 3
Viviana Simon
Icahn School of Medicine at Mount Sinai
Co-authored papers 3
Andrew Pekosz
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Paul M Sharp
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