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Author Details

Scott B Rothbart
Van Andel Institute
2009
71
33
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
38092287Mechanisms of DNA Methylation Regulatory Function and Crosstalk with Histone Lysine Methylation.J Mol Biol2024
36611042Global lysine methylome profiling using systematically characterized affinity reagents.Sci Rep2023
38076966Single-genome analysis reveals heterogeneous association of the Herpes Simplex Virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblasts.bioRxiv2023
37516105Ketolysis drives CD8<sup>+</sup> T cell effector function through effects on histone acetylation.Immunity2023
38054592Lysine methylation signaling in skeletal muscle biology: from myogenesis to clinical insights.Biochem J2023
37732208Mitotic chromatin marking governs asymmetric segregation of DNA damage.bioRxiv2023
37160995Streamlined quantitative analysis of histone modification abundance at nucleosome-scale resolution with siQ-ChIP version 2.0.Sci Rep2023
36945621Analysis of histone antibody specificity directly in sequencing data using siQ-ChIP.bioRxiv2023
37172591LKB1 controls inflammatory potential through CRTC2-dependent histone acetylation.Mol Cell2023
36153585ARID1A-dependent maintenance of H3.3 is required for repressive CHD4-ZMYND8 chromatin interactions at super-enhancers.BMC Biol2022
33472068HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies.Cell Rep2021
34473995Binding specificity and function of the SWI/SNF subunit SMARCA4 bromodomain interaction with acetylated histone H3K14.J Biol Chem2021
34819353A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer.Genes Dev2021
34009611Distinguishing Active Versus Passive DNA Demethylation Using Illumina MethylationEPIC BeadChip Microarrays.Methods Mol Biol2021
33308996Chromatin Regulation through Ubiquitin and Ubiquitin-like Histone Modifications.Trends Biochem Sci2021
32328492A Degenerate Peptide Library Approach to Reveal Sequence Determinants of Methyllysine-Driven Protein Interactions.Front Cell Dev Biol2020
33306668In silico APC/C substrate discovery reveals cell cycle-dependent degradation of UHRF1 and other chromatin regulators.PLoS Biol2020
33296650Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis.Cell Rep2020
33097091The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells.Epigenetics Chromatin2020
32699416Histone H3.3 phosphorylation amplifies stimulation-induced transcription.Nature2020
32302562Epigenetic Therapy for Epithelioid Sarcoma.Cell2020
30723142Trabectedin Inhibits EWS-FLI1 and Evicts SWI/SNF from Chromatin in a Schedule-dependent Manner.Clin Cancer Res2019
31727574A Read/Write Mechanism Connects p300 Bromodomain Function to H2A.Z Acetylation.iScience2019
31539507Lysine Methylation Regulators Moonlighting outside the Epigenome.Mol Cell2019
31481468The finger loop of the SRA domain in the E3 ligase UHRF1 is a regulator of ubiquitin targeting and is required for the maintenance of DNA methylation.J Biol Chem2019
30956060Defining UHRF1 Domains that Support Maintenance of Human Colon Cancer DNA Methylation and Oncogenic Properties.Cancer Cell2019
31127101Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.Nat Commun2019
29506131Comparative biochemical analysis of UHRF proteins reveals molecular mechanisms that uncouple UHRF2 from DNA methylation maintenance.Nucleic Acids Res2018
30166406Study of mitotic chromatin supports a model of bookmarking by histone modifications and reveals nucleosome deposition patterns.Genome Res2018
30104358Chromatin structure and its chemical modifications regulate the ubiquitin ligase substrate selectivity of UHRF1.Proc Natl Acad Sci U S A2018
30244833Examining the Roles of H3K4 Methylation States with Systematically Characterized Antibodies.Mol Cell2018
30498785A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity.Sci Adv2018
30523112A DNA methylation reader complex that enhances gene transcription.Science2018
29414941Structural basis for DNMT3A-mediated de novo DNA methylation.Nature2018
28630893A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex.Sci Adv2017
28293301Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions.Epigenetics Chromatin2017
29262320The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer.Cell Rep2017
28809825Analysis of Histone Antibody Specificity with Peptide Microarrays.J Vis Exp2017
27423857ArrayNinja: An Open Source Platform for Unified Planning and Analysis of Microarray Experiments.Methods Enzymol2016
27782467A fast, open source implementation of adaptive biasing potentials uncovers a ligand design strategy for the chromatin regulator BRD4.J Chem Phys2016
27749823Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a.Nat Cell Biol2016
27653685Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase.Cell Rep2016
27826357Systematic comparison of monoclonal versus polyclonal antibodies for mapping histone modifications by ChIP-seq.Epigenetics Chromatin2016
27595565Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1.Elife2016
27423856Substrate Specificity Profiling of Histone-Modifying Enzymes by Peptide Microarray.Methods Enzymol2016
25590533Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1.ACS Chem Biol2015
26299963An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1.Cell Rep2015
26651941Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation.Cell Host Microbe2015
26391395AMP-activated Protein Kinase (AMPK) Control of mTORC1 Is p53- and TSC2-independent in Pemetrexed-treated Carcinoma Cells.J Biol Chem2015
26338712A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin.J Biol Chem2015
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Collaborators

Brian D Strahl
University of North Carolina
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C David Allis
The Rockefeller University
Co-authored papers 4
Cheryl H Arrowsmith
University of Toronto
Co-authored papers 4
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EpiCypher Inc.
Co-authored papers 4
Stephen M Fuchs
Tufts University
Co-authored papers 3
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EpiCypher Inc.
Co-authored papers 3
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University of Pennsylvania
Co-authored papers 3
Brian Kuhlman
Co-authored papers 2
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Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University
Co-authored papers 2
Ettore Appella
Co-authored papers 2
Yinsheng Wang
Co-authored papers 2
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Washington University in St. Louis
Co-authored papers 2
Alon Goren
Co-authored papers 2
Kevin G Hardwick
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Co-authored papers 1
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Quantitative Biosciences Institute (QBI), University of California san francisco
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Princess Margaret Cancer Centre, University Health Network, University of Toronto
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Pengcheng Wang
Co-authored papers 1
Namit Singh
Co-authored papers 1
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Fran??ois-Michel Boisvert
Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CRCHUS)
Co-authored papers 1
Hyun-Soo Kim
Wonju Severance Christian Hospital
Co-authored papers 1
Eric E Bouhassira
Albert Einstein College of Medicine
Co-authored papers 1
Kelly K Foy
Co-authored papers 1
Rituparna Mukhopadhyay
Albert Einstein College of Medicine
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Brian D Dynlacht
New York University Cancer Institute, New York University School of Medicine
Co-authored papers 1
Yossi Farjoun
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Jesse H Arbuckle
National Institute of Allergy and Infectious Diseases
Co-authored papers 1
Adrianne Gladden-Young
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Release 1.2