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Author Details

William L Brown
University of Minnesota
1989
72
32
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
38049664The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance.Nat Genet2024
37298259DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo.Int J Mol Sci2023
37555667APOBEC3 degradation is the primary function of HIV-1 Vif determining virion infectivity in the myeloid cell line THP-1.mBio2023
38033156Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer.PLoS Genet2023
37034786APOBEC3 degradation is the primary function of HIV-1 Vif for virus replication in the myeloid cell line THP-1.bioRxiv2023
35930804An Immunogenic Model of KRAS-Mutant Lung Cancer Enables Evaluation of Targeted Therapy and Immunotherapy Combinations.Cancer Res2022
35471084Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 M<sup>pro</sup>/3CL<sup>pro</sup> in Living Cells.mBio2022
33444430Disease Expression and Familial Transmission of Fuchs Endothelial Corneal Dystrophy With and Without CTG18.1 Expansion.Invest Ophthalmol Vis Sci2021
33921405Structural Characterization of a Minimal Antibody against Human APOBEC3B.Viruses2021
32847850Functional and Structural Insights into a Vif/PPP2R5 Complex Elucidated Using Patient HIV-1 Isolates and Computational Modeling.J Virol2020
32060098The DNA Cytosine Deaminase APOBEC3B is a Molecular Determinant of Platinum Responsiveness in Clear Cell Ovarian Cancer.Clin Cancer Res2020
32094150MagnEdit-interacting factors that recruit DNA-editing enzymes to single base targets.Life Sci Alliance2020
33200129Gain-of-function assay for SARS-CoV-2 M <sup>pro</sup> inhibition in living cells.bioRxiv2020
30420783Epstein-Barr virus BORF2 inhibits cellular APOBEC3B to preserve viral genome integrity.Nat Microbiol2019
31665623HIV-1 Vif Triggers Cell Cycle Arrest by Degrading Cellular PPP2R5 Phospho-regulators.Cell Rep2019
31217276The DNA deaminase APOBEC3B interacts with the cell-cycle protein CDK4 and disrupts CDK4-mediated nuclear import of Cyclin D1.J Biol Chem2019
31611371The deaminase APOBEC3B triggers the death of cells lacking uracil DNA glycosylase.Proc Natl Acad Sci U S A2019
31544853A Rabbit Monoclonal Antibody against the Antiviral and Cancer Genomic DNA Mutating Enzyme APOBEC3B.Antibodies (Basel)2019
31145054HIV-1 restriction by endogenous APOBEC3G in the myeloid cell line THP-1.J Gen Virol2019
30578845A lentivirus-based system for Cas9/gRNA expression and subsequent removal by Cre-mediated recombination.Methods2019
30679582A panel of eGFP reporters for single base editing by APOBEC-Cas9 editosome complexes.Sci Rep2019
29290613The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism.Mol Cell2018
30224517APOBEC3H Subcellular Localization Determinants Define Zipcode for Targeting HIV-1 for Restriction.Mol Cell Biol2018
30297863Genetic and mechanistic basis for APOBEC3H alternative splicing, retrovirus restriction, and counteraction by HIV-1 protease.Nat Commun2018
30558640Natural APOBEC3C variants can elicit differential HIV-1 restriction activity.Retrovirology2018
29618650Simian Immunodeficiency Virus Vif and Human APOBEC3B Interactions Resemble Those between HIV-1 Vif and Human APOBEC3G.J Virol2018
29746667A fluorescent reporter for quantification and enrichment of DNA editing by APOBEC-Cas9 or cleavage by Cas9 in living cells.Nucleic Acids Res2018
29787764APOBEC3B Nuclear Localization Requires Two Distinct N-Terminal Domain Surfaces.J Mol Biol2018
29145554Prevalence and Associations of Central-Peripheral Rivalry-Type Diplopia in Patients With Epiretinal Membrane.JAMA Ophthalmol2017
28456546Causes of Diplopia in Patients With Epiretinal Membranes.Am J Ophthalmol2017
27016308APOBEC3G Expression Correlates with T-Cell Infiltration and Improved Clinical Outcomes in High-grade Serous Ovarian Carcinoma.Clin Cancer Res2016
25981045Lineage-Specific Viral Hijacking of Non-canonical E3 Ubiquitin Ligase Cofactors in the Evolution of Vif Anti-APOBEC3 Activity.Cell Rep2015
26420215The PKC/NF-κB signaling pathway induces APOBEC3B expression in multiple human cancers.Cancer Res2015
24503066Catalytic activity of APOBEC3F is required for efficient restriction of Vif-deficient human immunodeficiency virus.Virology2014
25411794Natural polymorphisms in human APOBEC3H and HIV-1 Vif combine in primary T lymphocytes to affect viral G-to-A mutation levels and infectivity.PLoS Genet2014
25237835Retinal and pontine striations: neurodiagnostic signs of autosomal recessive spastic ataxia of Charlevoix-Saguenay.J Neuroophthalmol2014
25168903Comprehensive assessment of genetic variants within TCF4 in Fuchs' endothelial corneal dystrophy.Invest Ophthalmol Vis Sci2014
23388464Subcellular localization of the APOBEC3 proteins during mitosis and implications for genomic DNA deamination.Cell Cycle2013
24154874APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma.Cancer Res2013
23938202The local dinucleotide preference of APOBEC3G can be altered from 5'-CC to 5'-TC by a single amino acid substitution.J Mol Biol2013
23640892Endogenous APOBEC3A DNA cytosine deaminase is cytoplasmic and nongenotoxic.J Biol Chem2013
23389445APOBEC3B is an enzymatic source of mutation in breast cancer.Nature2013
22181350First-in-class small molecule inhibitors of the single-strand DNA cytosine deaminase APOBEC3G.ACS Chem Biol2012
24832226A Comparison of Two Single-Stranded DNA Binding Models by Mutational Analysis of APOBEC3G.Biology (Basel)2012
22896697Methylcytosine and normal cytosine deamination by the foreign DNA restriction enzyme APOBEC3A.J Biol Chem2012
22446380APOBEC3B and AID have similar nuclear import mechanisms.J Mol Biol2012
20736869Use of dissimilar trifocals to equalize fields of view for asymmetric orbital positions secondary to progressive facial hemiatrophy.Ophthalmic Plast Reconstr Surg2011
21835787Human and rhesus APOBEC3D, APOBEC3F, APOBEC3G, and APOBEC3H demonstrate a conserved capacity to restrict Vif-deficient HIV-1.J Virol2011
21850184Copy number variation in the complement factor H-related genes and age-related macular degeneration.Mol Vis2011
21609218Vision rehabilitation of persons with age related macular degeneration.Semin Ophthalmol2011
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Collaborators

Reuben S Harris
University of Texas Health San Antonio
Co-authored papers 49
Michael A Carpenter
University of Minnesota
Co-authored papers 17
Rommie E Amaro
University of California
Co-authored papers 5
Ming Li
Department of Cancer Research Institute, University of South Australia
Co-authored papers 5
Anurag Rathore
Aaron Diamond AIDS Research Center, Columbia University Irving Medical Center
Co-authored papers 5
Judd F Hultquist
Northwestern University Feinberg School of Medicine
Co-authored papers 5
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Mayo Clinic
Co-authored papers 4
John S Albin
Massachusetts General Hospital
Co-authored papers 4
Keisuke Shindo
Graduate School of Medicine, Kyoto University
Co-authored papers 3
Dennis W Siemsen
Mayo Clinic
Co-authored papers 3
Scott H Kaufmann
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Co-authored papers 3
Ann L Oberg
Co-authored papers 3
Brett D Anderson
University of Minnesota
Co-authored papers 3
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Frederick National Laboratory for Cancer Research
Co-authored papers 2
Charles Swanton
Francis Crick Institute
Co-authored papers 2
Celia A Schiffer
University of Massachusetts Chan Medical School
Co-authored papers 2
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University of Massachusetts Medical School
Co-authored papers 2
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Mayo Clinic Rochester
Co-authored papers 2
Wei Chen
Co-authored papers 2
Kent R Bailey
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Co-authored papers 2
Gon??alo R Abecasis
Regeneron Pharmaceuticals Inc.
Co-authored papers 2
Rebecca S LaRue
Minnesota Supercomputing Institute, University of Minnesota
Co-authored papers 2
Daniel A Harki
University of Minnesota
Co-authored papers 2
Anand Swaroop
National Eye Institute, National Institutes of Health
Co-authored papers 2
Jeffrey R Johnson
Gladstone Institutes
Co-authored papers 2
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 2
Elena Harjes
Massey University
Co-authored papers 2
Peter Charbel Issa
Oxford Eye Hospital, Oxford University Hospitals NHS Foundation Trust
Co-authored papers 1
Hendrik P N Scholl
Institute of Molecular and Clinical Ophthalmology Basel
Co-authored papers 1
Saravut J Weroha
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Release 1.2