Author details

Full Name

Leonardo Brizuela

Affiliation

ORCID

Career Start Year

1987

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
22682222	The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism.		2012
21304545	Targeted resequencing of a genomic region influencing tameness and aggression reveals multiple signals of positive selection.	Heredity	2011
20448179	Targeted investigation of the Neandertal genome by array-based sequence capture.	Science	2010
20622853	Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development.	Nature	2010
20080586	Optimized detection of sequence variation in heterozygous genomes using DNA microarrays with isothermal-melting probes.	Proc Natl Acad Sci U S A	2010
20368986	Deep sequencing of target linkage assay-identified regions in familial breast cancer: methods, analysis pipeline and troubleshooting.	PLoS One	2010
19478811	Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing.		2009
19581485	High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing.	Genome Res	2009
18258921	Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets.	Genome Res	2008
17593976	A full-genomic sequence-verified protein-coding gene collection for Francisella tularensis.	PLoS One	2007
16869783	Screens using RNAi and cDNA expression as surrogates for genetics in mammalian tissue culture cells.	Cold Spring Harb Symp Quant Biol	2005
15928075	Building a human kinase gene repository: bioinformatics, molecular cloning, and functional validation.	Proc Natl Acad Sci U S A	2005
16075305	Understanding and modulating cyclin-dependent kinase inhibitor specificity: molecular modeling and biochemical evaluation of pyrazolopyrimidinones as CDK2/cyclin A and CDK4/cyclin D1 inhibitors.	Journal of Computer-Aided Molecular Design	2005
15249043	Bacterial cell-free system for high-throughput protein expression and a comparative analysis of Escherichia coli cell-free and whole cell expression systems.	Protein Expr Purif	2004
15489342	The Pseudomonas aeruginosa PA01 gene collection.	Genome Res	2004
15489329	High-throughput generation of P. falciparum functional molecules by recombinational cloning.	Genome Res	2004
12234520	The FLEXGene repository: exploiting the fruits of the genome projects by creating a needed resource to face the challenges of the post-genomic era.	Arch Med Res	2002
11738706	FLEXGene repository: from sequenced genomes to gene repositories for high-throughput functional biology and proteomics.	Mol Biochem Parasitol	2001
11514172	Identification of selective inhibitors of cyclin dependent kinase 4.	Bioorganic and Medicinal Chemistry Letters	2001
10843211	Structure-activity relationship studies of flavopiridol analogues.	Bioorganic and Medicinal Chemistry Letters	2000
10918611	SCF(beta-TRCP) and phosphorylation dependent ubiquitinationof I kappa B alpha catalyzed by Ubc3 and Ubc4.	Oncogene	2000
10393546	Mechanism of Cdk2/Cyclin E inhibition by p27 and p27 phosphorylation.	Biochemistry	1999
9751051	Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor p19INK4d.	Nature	1998
9353127	Structure of the cyclin-dependent kinase inhibitor p19Ink4d.	Nature	1997
9150368	Interaction between Cdc37 and Cdk4 in human cells.	Oncogene	1997
8674031	Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells.	Cancer Research	1996
7875200	Induction of interleukin-2 transcription by the hamster polyomavirus middle T antigen: a role for Fyn in T cell signal transduction.	Eur J Immunol	1995
7478520	Biochemical and mutagenic analysis of the melanoma tumor suppressor gene product/p16.	Oncogene	1995
1380159	Yeast FKBP-13 is a membrane-associated FK506-binding protein encoded by the nonessential gene FKB2.	Proceedings of the National Academy of Sciences of the United States of America	1992
1704127	FKB1 encodes a nonessential FK 506-binding protein in Saccharomyces cerevisiae and contains regions suggesting homology to the cyclophilins.	Proc Natl Acad Sci U S A	1991
1849074	A role for the p34cdc2 kinase and phosphatases in the regulation of phosphorylation and disassembly of lamin B2 during the cell cycle.	EMBO Journal	1991
1721295	Is FKBP involved in the immunosuppressive and/or toxic mechanism of action of FK 506?	Transplantation Proceedings	1991
1715022	Antifungal properties of the immunosuppressant FK-506: identification of an FK-506-responsive yeast gene distinct from FKB1.	Molecular and Cellular Biology	1991
2541912	The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells.	Cell	1989
2538242	Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF.	Cell	1989
2543971	Activation of human CDC2 protein as a histone H1 kinase is associated with complex formation with the p62 subunit.	Proceedings of the National Academy of Sciences of the United States of America	1989
2551679	Cyclin is a component of the sea urchin egg M-phase specific histone H1 kinase.	EMBO Journal	1989
2552322	Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication.	Nature	1989
2844417	cdc2 is a component of the M phase-specific histone H1 kinase: evidence for identity with MPF.	Cell	1988
3076080	Regulation of the vertebrate cell cycle by the cdc2 protein kinase.	Cold Spring Harbor Symposia on Quantitative Biology	1988
3046250	p34, a protein kinase involved in cell cycle regulation in eukaryotic cells.	Advances in Experimental Medicine and Biology	1988
3293802	The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis.	Cell	1988
3297353	Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+.	Cell	1987
3322810	p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase.	EMBO Journal	1987