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Author Details

Reuben S Harris
University of Texas Health San Antonio
1980
236
68
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
38049664The role of APOBEC3B in lung tumor evolution and targeted cancer therapy resistance.Nat Genet2024
36194133SARS-CoV-2 3CL<sup>pro</sup> mutations selected in a VSV-based system confer resistance to nirmatrelvir, ensitrelvir, and GC376.Sci Transl Med2023
37555667APOBEC3 degradation is the primary function of HIV-1 Vif determining virion infectivity in the myeloid cell line THP-1.mBio2023
37797615Human APOBEC3B promotes tumor development in vivo including signature mutations and metastases.Cell Rep Med2023
38001542Acute expression of human APOBEC3B in mice results in RNA editing and lethality.Genome Biol2023
37735199APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer.Nat Genet2023
37577509Mesoscale DNA Features Impact APOBEC3A and APOBEC3B Deaminase Activity and Shape Tumor Mutational Landscapes.bioRxiv2023
37821454Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A.Nat Commun2023
38033156Mutational impact of APOBEC3A and APOBEC3B in a human cell line and comparisons to breast cancer.PLoS Genet2023
37672599APOBEC Reporter Systems for Evaluating diNucleotide Editing Levels.CRISPR J2023
37565748Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism.J Virol2023
37190094Aberrant APOBEC3B Expression in Breast Cancer Is Linked to Proliferation and Cell Cycle Phase.Cells2023
36993515Rapid resistance profiling of SARS-CoV-2 protease inhibitors.Res Sq2023
36989354Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors.Sci Adv2023
37347719TP53/p53 Facilitates Stress-Induced Exosome and Protein Secretion by Adipocytes.Diabetes2023
37182813APEX3 - An Optimized Tool for Rapid and Unbiased Proximity Labeling.J Mol Biol2023
37034786APOBEC3 degradation is the primary function of HIV-1 Vif for virus replication in the myeloid cell line THP-1.bioRxiv2023
37474103Mitochondrial double-stranded RNA triggers induction of the antiviral DNA deaminase APOBEC3A and nuclear DNA damage.J Biol Chem2023
37298259DNA Deamination Is Required for Human APOBEC3A-Driven Hepatocellular Carcinoma In Vivo.Int J Mol Sci2023
36961501Evidence for virus-mediated oncogenesis in bladder cancers arising in solid organ transplant recipients.Elife2023
36478188Clinical Implications of APOBEC3-Mediated Mutagenesis in Breast Cancer.Clin Cancer Res2023
36781883APOBEC3B drives PKR-mediated translation shutdown and protects stress granules in response to viral infection.Nat Commun2023
36778493Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanism.bioRxiv2023
36909573Rapid resistance profiling of SARS-CoV-2 protease inhibitors.bioRxiv2023
36865194Human APOBEC3B promotes tumor heterogeneity <i>in vivo</i> including signature mutations and metastases.bioRxiv2023
36824964Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A.bioRxiv2023
36416305Primary mucosal melanomas of the head and neck are characterised by overexpression of the DNA mutating enzyme APOBEC3B.Histopathology2023
35194151Induction of APOBEC3-mediated genomic damage in urothelium implicates BK polyomavirus (BKPyV) as a hit-and-run driver for bladder cancer.Oncogene2022
35478219A VSV-based assay quantifies coronavirus Mpro/3CLpro/Nsp5 main protease activity and chemical inhibition.Commun Biol2022
35476445Cryo-EM structure of the EBV ribonucleotide reductase BORF2 and mechanism of APOBEC3B inhibition.Sci Adv2022
35471084Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 M<sup>pro</sup>/3CL<sup>pro</sup> in Living Cells.mBio2022
36458685Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases.Elife2022
36374108Ancestral APOBEC3B Nuclear Localization Is Maintained in Humans and Apes and Altered in Most Other Old World Primate Species.mSphere2022
36069545G<sub>1</sub>/S Cell Cycle Induction by Epstein-Barr Virus BORF2 Is Mediated by P53 and APOBEC3B.J Virol2022
35930804An Immunogenic Model of KRAS-Mutant Lung Cancer Enables Evaluation of Targeted Therapy and Immunotherapy Combinations.Cancer Res2022
35982678Transmissible SARS-CoV-2 variants with resistance to clinical protease inhibitors.bioRxiv2022
35272863The current toolbox for APOBEC drug discovery.Trends Pharmacol Sci2022
35140399Mapping clustered mutations in cancer reveals APOBEC3 mutagenesis of ecDNA.Nature2022
32632179Endogenous APOBEC3B overexpression characterizes HPV-positive and HPV-negative oral epithelial dysplasias and head and neck cancers.Mod Pathol2021
33510734Dual Functionality of HIV-1 Vif in APOBEC3 Counteraction and Cell Cycle Arrest.Front Microbiol2021
33673243Small-Angle X-ray Scattering Models of APOBEC3B Catalytic Domain in a Complex with a Single-Stranded DNA Inhibitor.Viruses2021
33671095APOBECs and Herpesviruses.Viruses2021
33921405Structural Characterization of a Minimal Antibody against Human APOBEC3B.Viruses2021
33658373Structural basis for recognition of distinct deaminated DNA lesions by endonuclease Q.Proc Natl Acad Sci U S A2021
35121902APOBEC3A drives deaminase domain-independent chromosomal instability to promote pancreatic cancer metastasis.Nat Cancer2021
34151211Small Molecule Inhibitors of Activation-Induced Deaminase Decrease Class Switch Recombination in B Cells.ACS Pharmacol Transl Sci2021
33320737R-Spondins 2 and 3 Are Overexpressed in a Subset of Human Colon and Breast Cancers.DNA Cell Biol2021
33478820Demystifying Cell Cycle Arrest by HIV-1 Vif.Trends Microbiol2021
32561747Structural basis of host protein hijacking in human T-cell leukemia virus integration.Nat Commun2020
32060098The DNA Cytosine Deaminase APOBEC3B is a Molecular Determinant of Platinum Responsiveness in Clear Cell Ovarian Cancer.Clin Cancer Res2020
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Collaborators

William L Brown
University of Minnesota
Co-authored papers 49
Michael A Carpenter
University of Minnesota
Co-authored papers 32
Ming Li
Department of Cancer Research Institute, University of South Australia
Co-authored papers 24
Daniel A Harki
University of Minnesota
Co-authored papers 15
Hiroshi Matsuo
Frederick National Laboratory for Cancer Research
Co-authored papers 13
Judd F Hultquist
Northwestern University Feinberg School of Medicine
Co-authored papers 13
Rommie E Amaro
University of California
Co-authored papers 11
John S Albin
Massachusetts General Hospital
Co-authored papers 11
Keisuke Shindo
Graduate School of Medicine, Kyoto University
Co-authored papers 11
Elena Harjes
Massey University
Co-authored papers 11
Brett D Anderson
University of Minnesota
Co-authored papers 10
Rebecca S LaRue
Minnesota Supercomputing Institute, University of Minnesota
Co-authored papers 8
Anurag Rathore
Aaron Diamond AIDS Research Center, Columbia University Irving Medical Center
Co-authored papers 8
John W M Martens
Erasmus Medical Center (MC) Cancer Institute
Co-authored papers 7
Stef??n R J??nsson
Institute for Experimental Pathology, University of Iceland
Co-authored papers 6
Valgerdur Andr??sd??ttir
Institute for Experimental Pathology, Biomedical Center, University of Iceland
Co-authored papers 6
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 5
Celia A Schiffer
University of Massachusetts Chan Medical School
Co-authored papers 5
Charles Swanton
Francis Crick Institute
Co-authored papers 5
Paul N Span
Radboud University Medical Center
Co-authored papers 5
Shivender M D Shandilya
University of Massachusetts Medical School
Co-authored papers 5
Kei Sato
The Institute of Medical Science, The University of Tokyo
Co-authored papers 5
John D Gross
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 4
Mohan Somasundaran
University of Massachusetts Chan Medical School
Co-authored papers 3
David A Largaespada
University of Minnesota
Co-authored papers 3
Alan Melcher
The Institute of Cancer Research
Co-authored papers 3
Jeffrey R Johnson
Gladstone Institutes
Co-authored papers 3
David J Stanley
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 3
Angela L Perkins
University of Minnesota
Co-authored papers 3
Chengjin Ye
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Release 1.2