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Author Details

Manu Vanaerschot
Columbia University Irving Medical Center
2008
53
29
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
34233174The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.Cell Chem Biol2022
35730550Workshop-based learning and networking: a scalable model for research capacity strengthening in low- and middle-income countries.Glob Health Action2022
36422597Luna Virus and Helminths in Wild <i>Mastomys natalensis</i> in Two Contrasting Habitats in Zambia: Risk Factors and Evidence of Virus Dissemination in Semen.Pathogens2022
36247976Metagenomic Pathogen Sequencing in Resource-Scarce Settings: Lessons Learned and the Road Ahead.Front Epidemiol2022
33788923Estimation of Secondary Household Attack Rates for Emergent Spike L452R Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Variants Detected by Genomic Surveillance at a Community-Based Testing Site in San Francisco.Clin Infect Dis2022
34348113Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention.Cell Chem Biol2022
33479319The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957.Sci Rep2021
33688689Estimation of secondary household attack rates for emergent SARS-CoV-2 variants detected by genomic surveillance at a community-based testing site in San Francisco.medRxiv2021
32359426Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity.Cell Chem Biol2020
31813848Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery.Cell Chem Biol2020
32078764Probing the Open Global Health Chemical Diversity Library for Multistage-Active Starting Points for Next-Generation Antimalarials.ACS Infect Dis2020
33112933Rapid deployment of SARS-CoV-2 testing: The CLIAHUB.PLoS Pathog2020
32929126Evaluation of whole genome amplification and bioinformatic methods for the characterization of Leishmania genomes at a single cell level.Sci Rep2020
32527780Complete Genome Sequence of a Novel Coronavirus (SARS-CoV-2) Isolate from Bangladesh.Microbiol Resour Announc2020
31830038Genomes of Leishmania parasites directly sequenced from patients with visceral leishmaniasis in the Indian subcontinent.PLoS Negl Trop Dis2019
29326268Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.Science2018
30107725Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors.J Am Chem Soc2018
29941635UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria.Antimicrob Agents Chemother2018
30523084Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.Science2018
30355750Erratum for Brunschwig et al., "UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria".Antimicrob Agents Chemother2018
28742826Macromolecular biosynthetic parameters and metabolic profile in different life stages of Leishmania braziliensis: Amastigotes as a functionally less active stage.PLoS One2017
28249021Single locus genotyping to track Leishmania donovani in the Indian subcontinent: Application in Nepal.PLoS Negl Trop Dis2017
28808258Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity.Nat Microbiol2017
28623350Multiplexed Spliced-Leader Sequencing: A high-throughput, selective method for RNA-seq in Trypanosomatids.Sci Rep2017
28536289Modulation of Aneuploidy in <i>Leishmania donovani</i> during Adaptation to Different <i>In Vitro</i> and <i>In Vivo</i> Environments and Its Impact on Gene Expression.mBio2017
26754204Correction to Antileishmanial Activity of a Series of N(2),N(4)-Disubstituted Quinazoline-2,4-diamines.J Med Chem2016
27400870Alice in microbes' land: adaptations and counter-adaptations of vector-borne parasitic protozoa and their hosts.FEMS Microbiol Rev2016
27003289Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent.Elife2016
25645828Experimental resistance to drug combinations in Leishmania donovani: metabolic and phenotypic adaptations.Antimicrob Agents Chemother2015
23815683Drug resistance in vectorborne parasites: multiple actors and scenarios for an evolutionary arms race.FEMS Microbiol Rev2014
24802998Treatment failure in leishmaniasis: drug-resistance or another (epi-) phenotype?Expert Rev Anti Infect Ther2014
24874647Antileishmanial activity of a series of N²,N⁴-disubstituted quinazoline-2,4-diamines.J Med Chem2014
22950457Drug-resistant microorganisms with a higher fitness--can medicines boost pathogens?Crit Rev Microbiol2013
24688684LC-MS metabolomics from study design to data-analysis - using a versatile pathogen as a test case.Comput Struct Biotechnol J2013
24105765Relapse after treatment with miltefosine for visceral leishmaniasis is associated with increased infectivity of the infecting Leishmania donovani strain.mBio2013
24020363Metabolic adaptations of Leishmania donovani in relation to differentiation, drug resistance, and drug pressure.Mol Microbiol2013
23980130In vitro susceptibility of Leishmania donovani to miltefosine in Indian visceral leishmaniasis.Am J Trop Med Hyg2013
23943823Reply to Das.Clin Infect Dis2013
23808607Evaluation of normalization methods to pave the way towards large-scale LC-MS-based metabolomics profiling experiments.OMICS2013
23425958Increasing failure of miltefosine in the treatment of Kala-azar in Nepal and the potential role of parasite drug resistance, reinfection, or noncompliance.Clin Infect Dis2013
23480865(Post-) Genomic approaches to tackle drug resistance in Leishmania.Parasitology2013
22119748Genome-wide SNP and microsatellite variation illuminate population-level epidemiology in the Leishmania donovani species complex.Infect Genet Evol2012
23285309Treatment of visceral leishmaniasis: model-based analyses on the spread of antimony-resistant L. donovani in Bihar, India.PLoS Negl Trop Dis2012
22753945Genetic markers for SSG resistance in Leishmania donovani and SSG treatment failure in visceral leishmaniasis patients of the Indian subcontinent.J Infect Dis2012
22389733Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background.PLoS Negl Trop Dis2012
20678296Comparison of gene expression patterns among Leishmania braziliensis clinical isolates showing a different in vitro susceptibility to pentavalent antimony.Parasitology2011
22038251Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.Genome Res2011
21829701Antimonial resistance in Leishmania donovani is associated with increased in vivo parasite burden.PLoS One2011
21819638Increased metacyclogenesis of antimony-resistant Leishmania donovani clinical lines.Parasitology2011
21572980Comparative gene expression analysis throughout the life cycle of Leishmania braziliensis: diversity of expression profiles among clinical isolates.PLoS Negl Trop Dis2011
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Collaborators

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Co-authored papers 2
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Institute of Integrative Biology, University of Liverpool
Co-authored papers 1
Howard Hughes Medical Institute, University of California at Berkeley
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
University of California san francisco
Co-authored papers 1
Stanford University School of Medicine
Co-authored papers 1
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Co-authored papers 1
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Co-authored papers 1
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Robert Wood Johnson Foundation in Princeton
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University of California berkeley
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