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Author Details

Kenneth Stuart
Seattle Children's Research Institute
1970
290
67
Christopher Churas (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36865177mt-LAF3 is a pseudouridine synthase ortholog required for mitochondrial rRNA and mRNA gene expression in <i>Trypanosoma brucei</i>.bioRxiv2023
37742784RNA editing catalytic complexes edit multiple mRNA sites non-processively in Trypanosoma brucei.Mol Biochem Parasitol2023
37246647Trypanosome RNA helicase KREH2 differentially controls non-canonical editing and putative repressive structure via a novel proposed 'bifunctional' gRNA in mRNA A6.Nucleic Acids Res2023
37474258Multiple domains of the integral KREPA3 protein are critical for the structure and precise functions of RNA editing catalytic complexes in <i>Trypanosoma brucei</i>.RNA2023
37268169mt-LAF3 is a pseudouridine synthase ortholog required for mitochondrial rRNA and mRNA gene expression in Trypanosoma brucei.Int J Parasitol2023
37131796Multiple domains of the integral KREPA3 protein are critical for the structure and precise functions of RNA Editing Catalytic Complexes in <i>Trypanosoma brucei</i>.bioRxiv2023
37195999Distinct immune responses associated with vaccination status and protection outcomes after malaria challenge.PLoS Pathog2023
36400448KRGG1 function in RNA editing in <i>Trypanosoma brucei</i>.RNA2023
35262071BCG revaccination qualitatively and quantitatively enhances SARS-CoV-2 spike-specific neutralizing antibody and T cell responses induced by the COVISHIELD<sup>â¿¢</sup> vaccine in SARS-CoV-2 seronegative young Indian adults.Res Sq2022
36591224Longitudinal immune profiling after radiation-attenuated sporozoite vaccination reveals coordinated immune processes correlated with malaria protection.Front Immunol2022
36268023Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELDâ¿¢ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adults.Front Immunol2022
36095119Domain function and predicted structure of three heterodimeric endonuclease subunits of RNA editing catalytic complexes in Trypanosoma brucei.Nucleic Acids Res2022
35031601Preimmunization correlates of protection shared across malaria vaccine trials in adults.NPJ Vaccines2022
35060479Transcriptional correlates of malaria in RTS,S/AS01-vaccinated African children: a matched case-control study.Elife2022
35108339Systems analysis of immune responses to attenuated P. falciparum malaria sporozoite vaccination reveals excessive inflammatory signatures correlating with impaired immunity.PLoS Pathog2022
34243763Early whole blood transcriptional responses to radiation-attenuated Plasmodium falciparum sporozoite vaccination in malaria naïve and malaria pre-exposed adult volunteers.Malar J2021
33499880Role of human Pegivirus infections in whole Plasmodium falciparum sporozoite vaccination and controlled human malaria infection in African volunteers.Virol J2021
32191849Lexis and Grammar of Mitochondrial RNA Processing in Trypanosomes.Trends Parasitol2020
33119588The phosphoinositide regulatory network in Trypanosoma brucei: Implications for cell-wide regulation in eukaryotes.PLoS Negl Trop Dis2020
32415811OMIP-064: A 27-Color Flow Cytometry Panel to Detect and Characterize Human NK Cells and Other Innate Lymphoid Cell Subsets, MAIT Cells, and γδ T Cells.Cytometry A2020
30420356Nuclear Phosphatidylinositol 5-Phosphatase Is Essential for Allelic Exclusion of Variant Surface Glycoprotein Genes in Trypanosomes.Mol Cell Biol2019
31731198Plasmodium Secretion Induces Hepatocyte Lysosome Exocytosis and Promotes Parasite Entry.iScience2019
31743110BCG revaccination boosts adaptive polyfunctional Th1/Th17 and innate effectors in IGRA+ and IGRA- Indian adults.JCI Insight2019
31171708Editosome RNase III domain interactions are essential for editing and differ between life cycle stages in <i>Trypanosoma brucei</i>.RNA2019
29168382Comparative Proteomic Analysis of Lysine Acetylation in Trypanosomes.J Proteome Res2018
29920562Whole blood transcriptome changes following controlled human malaria infection in malaria pre-exposed volunteers correlate with parasite prepatent period.PLoS One2018
29359194RNase III Domain of KREPB9 and KREPB10 Association with Editosomes in <i>Trypanosoma brucei</i>.mSphere2018
29491740Transcriptional Regulation of Telomeric Expression Sites and Antigenic Variation in Trypanosomes.Curr Genomics2018
29514930Inositol polyphosphate multikinase regulation of Trypanosoma brucei life stage development.Mol Biol Cell2018
28576979Controlled Human Malaria Infection Leads to Long-Lasting Changes in Innate and Innate-like Lymphocyte Populations.J Immunol2017
28334821In vivo cleavage specificity of Trypanosoma brucei editosome endonucleases.Nucleic Acids Res2017
28802260The essential functions of KREPB4 are developmentally distinct and required for endonuclease association with editosomes.RNA2017
27133314Chemogenetic Characterization of Inositol Phosphate Metabolic Pathway Reveals Druggable Enzymes for Targeting Kinetoplastid Parasites.Cell Chem Biol2016
27708162The Architecture of Trypanosoma brucei editosomes.Proc Natl Acad Sci U S A2016
25404564Bloodstream form Trypanosoma brucei do not require mRPN1 for gRNA processing.RNA2015
26304125Differential Editosome Protein Function between Life Cycle Stages of Trypanosoma brucei.J Biol Chem2015
26370513Identification by Random Mutagenesis of Functional Domains in KREPB5 That Differentially Affect RNA Editing between Life Cycle Stages of Trypanosoma brucei.Mol Cell Biol2015
26043892GMP synthase is essential for viability and infectivity of Trypanosoma brucei despite a redundant purine salvage pathway.Mol Microbiol2015
25964327Inositol phosphate pathway controls transcription of telomeric expression sites in trypanosomes.Proc Natl Acad Sci U S A2015
25961325Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa and Trypanosoma structures.Acta Crystallogr F Struct Biol Commun2015
25780218Personal reflections on RNA: an emphasis on trypanosomes.RNA2015
25568942Genome and phylogenetic analyses of Trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty.PLoS Negl Trop Dis2015
24562907Genetic validation of aminoacyl-tRNA synthetases as drug targets in Trypanosoma brucei.Eukaryot Cell2014
26443079Kinases as druggable targets in trypanosomatid protozoan parasites.Chem Rev2014
25064607Tb927.10.6900 encodes the glucosyltransferase involved in synthesis of base J in Trypanosoma brucei.Mol Biochem Parasitol2014
24903413Computer-aided discovery of Trypanosoma brucei RNA-editing terminal uridylyl transferase 2 inhibitors.Chem Biol Drug Des2014
24530464N¹,N¹-Dimethyl-N³-(3-(trifluoromethyl)phenethyl)propane-1,3-diamine, a new lead for the treatment of human African trypanosomiasis.Eur J Med Chem2014
23134734A spectrophotometric assay for quantitative measurement of aminoacyl-tRNA synthetase activity.J Biomol Screen2013
24126051A multiple aminoacyl-tRNA synthetase complex that enhances tRNA-aminoacylation in African trypanosomes.Mol Cell Biol2013
23685343Identification of essential and non-essential protein kinases by a fusion PCR method for efficient production of transgenic Trypanosoma brucei.Mol Biochem Parasitol2013
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Collaborators

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University of Guelph
Co-authored papers 74
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University of Washington School of Medicine
Co-authored papers 9
Margaret Juliana McElrath
Co-authored papers 9
Elizabeth A Worthey
Heersink School of Medicine, The University of Alabama at Birmingham
Co-authored papers 7
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Co-authored papers 6
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Fred Hutchinson Cancer Center
Co-authored papers 4
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Inc., 9800 Medical Center Drive
Co-authored papers 4
Maxwell L Neal
Co-authored papers 4
Matthew Berriman
Wellcome Sanger Institute
Co-authored papers 4
Christiane Hertz-Fowler
Institute of Integrative Biology, University of Liverpool
Co-authored papers 3
Steven L Salzberg
Center for Computational Biology, Johns Hopkins University
Co-authored papers 3
Elodie Ghedin
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Co-authored papers 3
Christy Vogt
Co-authored papers 3
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Institute for Genome Sciences, University of Maryland School of Medicine
Co-authored papers 3
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Harvard Medical School
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Wesley C Van Voorhis
Center for Emerging and Re-emerging Infectious Diseases, University of Washington
Co-authored papers 2
Frederick S Buckner
University of Washington
Co-authored papers 2
Alka Saxena
Biomedical Research Centre at Guy's Hospital
Co-authored papers 2
Shiguo Zhou
Sage Science Inc.
Co-authored papers 2
Neil Hall
Earlham Institute
Co-authored papers 2
Claire M Fraser
Institute for Genome Sciences, University of Maryland School of Medicine
Co-authored papers 2
Lee Murphy
Edinburgh Clinical Research Facility, University of Edinburgh
Co-authored papers 2
Jeremy Peterson
The Institute for Genomic Research, 9712 Medical Center Drive
Co-authored papers 2
Jennifer R Wortman
Broad Institute of MIT and Harvard
Co-authored papers 2
Samuel V Angiuoli
Personal Genome Diagnostics Inc.
Co-authored papers 2
Jonathan Crabtree
Institute for Genome Sciences, University of Maryland School of Medicine
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David C Schwartz
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Release 1.2