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Author Details

Philip Hieter
University of British Columbia
1974
199
79
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37556311Highlighting rare disease research with a GENETICS and G3 series on genetic models of rare diseases.Genetics2023
37556359Highlighting rare disease research with a GENETICS and G3 series on genetic models of rare diseases.G3 (Bethesda)2023
34180355A nuclear proteome localization screen reveals the exquisite specificity of Gpn2 in RNA polymerase biogenesis.Cell Cycle2021
33782138Modeling DNA trapping of anticancer therapeutic targets using missense mutations identifies dominant synthetic lethal interactions.Proc Natl Acad Sci U S A2021
34590269Mapping Synthetic Dosage Lethal Genetic Interactions in Saccharomyces cerevisiae.Methods Mol Biol2021
34462321Paralogous synthetic lethality underlies genetic dependencies of the cancer-mutated gene <i>STAG2</i>.Life Sci Alliance2021
32414869A Multimodal Genotoxic Anticancer Drug Characterized by Pharmacogenetic Analysis in <i>Caenorhabditis elegans</i>.Genetics2020
32032513The Canadian Rare Diseases Models and Mechanisms (RDMM) Network: Connecting Understudied Genes to Model Organisms.Am J Hum Genet2020
31937519Cross-Species Complementation of Nonessential Yeast Genes Establishes Platforms for Testing Inhibitors of Human Proteins.Genetics2020
31537797MRE11-RAD50-NBS1 promotes Fanconi Anemia R-loop suppression at transcription-replication conflicts.Nat Commun2019
29043613The Chromosome Transmission Fidelity Assay for Measuring Chromosome Loss in Yeast.Methods Mol Biol2018
29273626MinION-based long-read sequencing and assembly extends the <i>Caenorhabditis elegans</i> reference genome.Genome Res2018
27452366Canonical DNA Repair Pathways Influence R-Loop-Driven Genome Instability.J Mol Biol2017
28475856International Cooperation to Enable the Diagnosis of All Rare Genetic Diseases.Am J Hum Genet2017
28211448CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.Nat Commun2017
28649135Synthetic lethality and cancer.Nat Rev Genet2017
28874452Model Organisms Facilitate Rare Disease Diagnosis and Therapeutic Research.Genetics2017
27551064Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer.Proc Natl Acad Sci U S A2016
27585847Dosage Mutator Genes in Saccharomyces cerevisiae: A Novel Mutator Mode-of-Action of the Mph1 DNA Helicase.Genetics2016
26175450An Updated Collection of Sequence Barcoded Temperature-Sensitive Alleles of Yeast Essential Genes.G3 (Bethesda)2015
26354769Complementation of Yeast Genes with Human Genes as an Experimental Platform for Functional Testing of Human Genetic Variants.Genetics2015
26354767Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint.Genetics2015
24449689An E4 ligase facilitates polyubiquitination of plant immune receptor resistance proteins in Arabidopsis.Plant Cell2014
25316782Understanding rare disease pathogenesis: a grand challenge for model organisms.Genetics2014
24743342Genome-wide profiling of yeast DNA:RNA hybrid prone sites with DRIP-chip.PLoS Genet2014
24794811Mechanisms of genome instability induced by RNA-processing defects.Trends Genet2014
24653001Synthetic cytotoxicity: digenic interactions with TEL1/ATM mutations reveal sensitivity to low doses of camptothecin.Genetics2014
24336748Genome destabilizing mutator alleles drive specific mutational trajectories in Saccharomyces cerevisiae.Genetics2014
24356817Glioblastoma cells containing mutations in the cohesin component STAG2 are sensitive to PARP inhibition.Mol Cancer Ther2014
23333522Synthetic lethality and cancer: cohesin and PARP at the replication fork.Trends Genet2013
23935490The Salmonella type III effector SspH2 specifically exploits the NLR co-chaperone activity of SGT1 to subvert immunity.PLoS Pathog2013
23932120From structure to systems: high-resolution, quantitative genetic analysis of RNA polymerase II.Cell2013
24002644Synthetic lethal targeting of superoxide dismutase 1 selectively kills RAD54B-deficient colorectal cancer cells.Genetics2013
23633133The 2013 Thomas Hunt Morgan Medal: Thomas Douglas Petes.Genetics2013
23755103Sequencing of candidate chromosome instability genes in endometrial cancers reveals somatic mutations in ESCO1, CHTF18, and MRE11A.PLoS One2013
23390603Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork.G3 (Bethesda)2013
23382697An evolutionarily conserved synthetic lethal interaction network identifies FEN1 as a broad-spectrum target for anticancer therapeutic development.PLoS Genet2013
23267056Biogenesis of RNA polymerases II and III requires the conserved GPN small GTPases in Saccharomyces cerevisiae.Genetics2013
22198145Mutability and mutational spectrum of chromosome transmission fidelity genes.Chromosoma2012
23104009Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes.Nat Genet2012
22279048R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants.Genes Dev2012
22412391Synthetic lethality of cohesins with PARPs and replication fork mediators.PLoS Genet2012
21423216YB-1 evokes susceptibility to cancer through cytokinesis failure, mitotic dysfunction and HER2 amplification.Oncogene2011
22384335G3, GENETICS, and the GSA: Two Journals, One Mission.G3 (Bethesda)2011
21908741G3, GENETICS, and the GSA: Two Journals, One Mission.Genetics2011
21901109Predisposition to cancer caused by genetic and functional defects of mammalian Atad5.PLoS Genet2011
21552543The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components.PLoS Genet2011
20174551Proteasome nuclear activity affects chromosome stability by controlling the turnover of Mms22, a protein important for DNA repair.PLoS Genet2010
20946811Making temperature-sensitive mutants.Methods Enzymol2010
20967232Subtle alterations in PCNA-partner interactions severely impair DNA replication and repair.PLoS Biol2010
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Collaborators

Johns Hopkins University School of Medicine
Co-authored papers 18
Co-authored papers 13
Precision Medicine Network Inc.
Co-authored papers 12
University of Toronto
Co-authored papers 7
Institute for Systems Genetics, NYU School of Medicine
Co-authored papers 7
Co-authored papers 6
Co-authored papers 5
Ottawa Institute of Systems Biology, University of Ottawa, University of Calgary
Co-authored papers 5
National Human Genome Research Institute, National Institutes of Health
Co-authored papers 5
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard
Co-authored papers 5
University of Toronto
Co-authored papers 4
Co-authored papers 4
University of Washington
Co-authored papers 4
Children's Hospital of Eastern Ontario
Co-authored papers 4
University of California San Francisco
Co-authored papers 4
Institute of Molecular Systems Biology, ETH Zurich
Co-authored papers 3
Stanford University
Co-authored papers 3
National Human Genome Research Institute, National Institutes of Health
Co-authored papers 3
University of Toronto, 1 King's College Circle
Co-authored papers 3
Conway Institute of Biomedical and Biomolecular Sciences, University College Dublin
Co-authored papers 3
University of Colorado School of Medicine
Co-authored papers 3
College Street, University of Toronto
Co-authored papers 3
Queen's University
Co-authored papers 3
University of British Columbia
Co-authored papers 3
Boston University School of Medicine, Boston University
Co-authored papers 3
Indiana University School of Medicine
Co-authored papers 3
Co-authored papers 3
National Human Genome Research Institute, National Institutes of Health
Co-authored papers 3
Co-authored papers 3
Co-authored papers 3