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Author Details

William W Kwok
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
1982
246
62
Sarah J Ratcliffe (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36703975Characterizing T cell responses to enzymatically modified beta cell neo-epitopes.Front Immunol2023
37003475Distinct trajectories distinguish antigen-specific T cells in peanut-allergic individuals undergoing oral immunotherapy.J Allergy Clin Immunol2023
37474341Technical Validation and Utility of an HLA Class II Tetramer Assay for Type 1 Diabetes: A Multicenter Study.J Clin Endocrinol Metab2023
34601735Specific T cells targeting Staphylococcus aureus fibronectin-binding protein 1 induce a type 2/type 1 inflammatory response in sensitized atopic dermatitis patients.Allergy2022
35746736High and Sustained Ex Vivo Frequency but Altered Phenotype of SARS-CoV-2-Specific CD4<sup>+</sup> T-Cells in an Anti-CD20-Treated Patient with Prolonged COVID-19.Viruses2022
36524209Bystander CD4<sup>+</sup> T cells infiltrate human tumors and are phenotypically distinct.Oncoimmunology2022
35990517Single cell transcriptomics and TCR reconstruction reveal CD4 T cell response to MHC-II-restricted APOB epitope in human cardiovascular disease.Nat Cardiovasc Res2022
36389825HLA-DR3 restricted environmental epitopes from the bacterium <i>Clostridium tetani</i> have T cell cross-reactivity to the SLE-related autoantigen SmD.Front Immunol2022
35878027A gut microbial peptide and molecular mimicry in the pathogenesis of type 1 diabetes.Proc Natl Acad Sci U S A2022
34986197Correction: Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19.PLoS Pathog2022
33130104Evaluating Responses to Gluten Challenge: A Randomized, Double-Blind, 2-Dose Gluten Challenge Trial.Gastroenterology2021
33768201<i>In vitro</i> and <i>ex vivo</i> functional characterization of human HLA-DRB1â¿¿04 restricted T cell receptors.J Transl Autoimmun2021
33928551Identification of Human Antigen-Specific CD4+ Cells with Peptide-MHC Multimer Technologies.Methods Mol Biol2021
34972837Biased TCR gene usage in citrullinated Tenascin C specific T-cells in rheumatoid arthritis.Sci Rep2021
34965282Cross-reactive and mono-reactive SARS-CoV-2 CD4+ T cells in prepandemic and COVID-19 convalescent individuals.PLoS Pathog2021
34529740Broadly directed SARS-CoV-2-specific CD4+ T cell response includes frequently detected peptide specificities within the membrane and nucleoprotein in patients with acute and resolved COVID-19.PLoS Pathog2021
34726156Impaired HA-specific T follicular helper cell and antibody responses to influenza vaccination are linked to inflammation in humans.Elife2021
34806648Autoreactive T cell receptors with shared germline-like α chains in type 1 diabetes.JCI Insight2021
34350827Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy.Elife2021
33253683Recurrent Clostridioides difficile Infection Is Associated With Impaired T Helper Type 17 Immunity to C difficile Toxin B.Gastroenterology2021
31383567Restricted myeloperoxidase epitopes drive the adaptive immune response in MPO-ANCA vasculitis.J Autoimmun2020
32060144Increased islet antigen-specific regulatory and effector CD4<sup>+</sup> T cells in healthy individuals with the type 1 diabetes-protective haplotype.Sci Immunol2020
33091337HLA-DR15 Molecules Jointly Shape an Autoreactive T Cell Repertoire in Multiple Sclerosis.Cell2020
32973217Ontogeny of different subsets of yellow fever virus-specific circulatory CXCR5<sup>+</sup> CD4<sup>+</sup> T cells after yellow fever vaccination.Sci Rep2020
32766581Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy.bioRxiv2020
32868339Next-Generation HLA Sequence Analysis Uncovers Seven HLA-DQ Amino Acid Residues and Six Motifs Resistant to Childhood Type 1 Diabetes.Diabetes2020
32245799Motifs of Three HLA-DQ Amino Acid Residues (α44, β57, β135) Capture Full Association With the Risk of Type 1 Diabetes in DQ2 and DQ8 Children.Diabetes2020
32169380Nasal allergen challenge and environmental exposure chamber challenge: A randomized trial comparing clinical and biological responses to cat allergen.J Allergy Clin Immunol2020
32320734Human T<sub>H</sub>1 and T<sub>H</sub>2 cells targeting rhinovirus and allergen coordinately promote allergic asthma.J Allergy Clin Immunol2020
32291282Hybrid Insulin Peptides Are Recognized by Human T Cells in the Context of DRB1*04:01.Diabetes2020
32423478Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis.BMC Immunol2020
30485456Der p 1-specific regulatory T-cell response during house dust mite allergen immunotherapy.Allergy2019
31405946Human CD4<sup>+</sup> T Cells Specific for Merkel Cell Polyomavirus Localize to Merkel Cell Carcinomas and Target a Required Oncogenic Domain.Cancer Immunol Res2019
31457096Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer-mediated autoimmune diabetes.Sci Adv2019
31572352Systematic Assessment of Immune Marker Variation in Type 1 Diabetes: A Prospective Longitudinal Study.Front Immunol2019
31227334Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity.Cell Host Microbe2019
31337800HCV-specific CD4+ T cells of patients with acute and chronic HCV infection display high expression of TIGIT and other co-inhibitory molecules.Sci Rep2019
30926644Epitope Selection for HLA-DQ2 Presentation: Implications for Celiac Disease and Viral Defense.J Immunol2019
31127057Eleven Amino Acids of HLA-DRB1 and Fifteen Amino Acids of HLA-DRB3, 4, and 5 Include Potentially Causal Residues Responsible for the Risk of Childhood Type 1 Diabetes.Diabetes2019
30952805How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.Sci Immunol2019
31147953Identification of Human Antigen-Specific CD4<sup>+</sup> T-Cells with Peptide-MHC Multimer Technologies.Methods Mol Biol2019
31077596Modulation of CRTh2 expression on allergen-specific T cells following peptide immunotherapy.Allergy2019
30428974Analysis of pancreatic beta cell specific CD4+ T cells reveals a predominance of proinsulin specific cells.Cell Immunol2019
29255035C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes.Proc Natl Acad Sci U S A2018
29867922SV-BR-1-GM, a Clinically Effective GM-CSF-Secreting Breast Cancer Cell Line, Expresses an Immune Signature and Directly Activates CD4<sup>+</sup> T Lymphocytes.Front Immunol2018
29988522Heterogeneity of Ara h Component-Specific CD4 T Cell Responses in Peanut-Allergic Subjects.Front Immunol2018
29853344Memory T cells specific to citrullinated α-enolase are enriched in the rheumatic joint.J Autoimmun2018
30039125Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting.Lab Chip2018
30139253Ratiometric Barcoding for Mass Cytometry.Anal Chem2018
30455401DRB4*01:01 Has a Distinct Motif and Presents a Proinsulin Epitope That Is Recognized in Subjects with Type 1 Diabetes.J Immunol2018
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Collaborators

Wash Benaroya Research Institute at Virginia Mason
Co-authored papers 61
Benaroya Research Institute
Co-authored papers 25
Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 19
Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
Co-authored papers 16
City of Hope Medical Center, Beckman Research Institute
Co-authored papers 16
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 12
Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology
Co-authored papers 10
Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 10
Co-authored papers 8
University of Washington School of Medicine
Co-authored papers 6
University of Virginia School of Medicine
Co-authored papers 5
Benaroya Research Institute at Virginia Mason
Co-authored papers 5
University of Virginia
Co-authored papers 5
Center for Systems Immunology, Benaroya Research Institute
Co-authored papers 5
Yale School of Medicine, Yale School of Public Health
Co-authored papers 5
University of Virginia School of Medicine
Co-authored papers 4
Bach Mai hospital
Co-authored papers 4
Uniformed Services University of the Health Sciences
Co-authored papers 4
University of Washington School of Medicine
Co-authored papers 4
Co-authored papers 3
8Benaroya Research Institute
Co-authored papers 3
Co-authored papers 3
Co-authored papers 3
Benaroya Research Institute at Virginia Mason
Co-authored papers 2
Co-authored papers 2
National Institute of Allergy and Infectious Diseases, National Institutes of Health
Co-authored papers 2
University of Pennsylvania Department of Pathology & Laboratory Medicine
Co-authored papers 2
Center for Systems Immunology, Benaroya Research Institute
Co-authored papers 2
Co-authored papers 2
Massachusetts General Hospital and Harvard Medical School
Co-authored papers 2