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Author Details

Raymond Hui
University of Toronto
1991
55
29
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
32278713Safe and successful treatment of depression with electroconvulsive therapy in a patient with implanted spinal cord stimulators.Brain Stimul2020
30679438Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.Nat Commun2019
31239348Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.Proc Natl Acad Sci U S A2019
29436819Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry.ACS Infect Dis2018
27966810Discovery of a PCAF Bromodomain Chemical Probe.Angew Chem Int Ed Engl2017
28162900Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor.Bioorg Med Chem2017
28933846Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii.J Med Chem2017
28874661A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.Nat Commun2017
26933036Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca2+ Signaling.J Biol Chem2016
27379343Identification of small molecule inhibitors that block the <i>Toxoplasma gondii</i> rhoptry kinase ROP18.ACS Infect Dis2016
26934697Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds.PLoS One2016
26002073Designing selective inhibitors for calcium-dependent protein kinases in apicomplexans.Trends Pharmacol Sci2015
26112892Biochemical characterization of FIKK8--A unique protein kinase from the malaria parasite Plasmodium falciparum and other apicomplexans.Mol Biochem Parasitol2015
25847873Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design.Biochim Biophys Acta2015
25945703Solution-state NMR structure of the putative morphogene protein BolA (PFE0790c) from Plasmodium falciparum.Acta Crystallogr F Struct Biol Commun2015
23192353Structural insights into the inactive subunit of the apicoplast-localized caseinolytic protease complex of Plasmodium falciparum.J Biol Chem2013
24147171Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design.PLoS Negl Trop Dis2013
22429898Crystal structures from the Plasmodium peroxiredoxins: new insights into oligomerization and product binding.BMC Struct Biol2012
22539638Novel insights into the regulation of malarial calcium-dependent protein kinase 1.FASEB J2012
22676716Phosphoglucomutase is absent in Trypanosoma brucei and redundantly substituted by phosphomannomutase and phospho-N-acetylglucosamine mutase.Mol Microbiol2012
22392982Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity.Proc Natl Acad Sci U S A2012
21084289Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.J Biol Chem2011
22020785Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction.Proteins2011
21853016Characterization of 14-3-3 proteins from Cryptosporidium parvum.PLoS One2011
21962082The Cryptosporidium parvum kinome.BMC Genomics2011
21531872Characterization, localization, essentiality, and high-resolution crystal structure of glucosamine 6-phosphate N-acetyltransferase from Trypanosoma brucei.Eukaryot Cell2011
21689687Characterization of a new phosphatase from Plasmodium.Mol Biochem Parasitol2011
21287613Structures of parasitic CDPK domains point to a common mechanism of activation.Proteins2011
20083609Structure and function of a G-actin sequestering protein with a vital role in malaria oocyst development inside the mosquito vector.J Biol Chem2010
21147463Phosphorylation of immunity-related GTPases by a Toxoplasma gondii-secreted kinase promotes macrophage survival and virulence.Cell Host Microbe2010
20724435Identification, subcellular localization, biochemical properties, and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylase.Glycobiology2010
20887733The Clp chaperones and proteases of the human malaria parasite Plasmodium falciparum.J Mol Biol2010
20856875The crystal structure of Toxoplasma gondii pyruvate kinase 1.PLoS One2010
20485436Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma.Nature2010
20360736N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.Nature2010
20436473Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium.Nat Struct Mol Biol2010
19197235Novel structural and regulatory features of rhoptry secretory kinases in Toxoplasma gondii.EMBO J2009
19691130Crystallographic structure of the tetratricopeptide repeat domain of Plasmodium falciparum FKBP35 and its molecular interaction with Hsp90 C-terminal pentapeptide.Protein Sci2009
19465561Forward genetics in Toxoplasma gondii reveals a family of rhoptry kinases that mediates pathogenesis.Eukaryot Cell2009
19470714Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands.J Biomol Screen2009
18235434Protein production and purification.Nat Methods2008
19101474Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis.Chem Biol2008
17125854Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.Mol Biochem Parasitol2007
17982461In situ proteolysis for protein crystallization and structure determination.Nat Methods2007
17656197Comparison of two ventilation techniques during general anesthesia for extracorporeal shock wave lithotripsy: high-frequency jet ventilation versus spontaneous ventilation with a laryngeal mask airway.Urology2007
17822713Crystal structure of Plasmodium falciparum spermidine synthase in complex with the substrate decarboxylated S-adenosylmethionine and the potent inhibitors 4MCHA and AdoDATO.J Mol Biol2007
17290979A potent, covalent inhibitor of orotidine 5'-monophosphate decarboxylase with antimalarial activity.J Med Chem2007
16337958Engineering of recombinant antibody fragments to methamphetamine by anchored periplasmic expression.J Immunol Methods2006
17035505Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination.Proc Natl Acad Sci U S A2006
17092916Screening for ligands using a generic and high-throughput light-scattering-based assay.J Biomol Screen2006
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Collaborators

Human Health Therapeutics Research Centre, National Research Council Canada
Co-authored papers 8
University of Toronto
Co-authored papers 7
Ecole Polytechnique Federale de Lausanne, Global Health Institute
Co-authored papers 5
University of Toronto
Co-authored papers 5
Center for Emerging and Re-emerging Infectious Diseases, University of Washington
Co-authored papers 3
Karolinska Institutet
Co-authored papers 3
Everett Community College
Co-authored papers 3
Botnar Research Centre, University of Oxford
Co-authored papers 3
University of Toronto
Co-authored papers 3
Center for Structural Biology of Infectious Diseases, University of Chicago
Co-authored papers 3
University of California San Francisco
Co-authored papers 3
Karolinska Institutet, BioClinicum J6
Co-authored papers 3
University of Toronto
Co-authored papers 2
Columbia University
Co-authored papers 2
Karolinska Institutet
Co-authored papers 2
Institute of Pharmaceutical Chemistry, Goethe University
Co-authored papers 2
University of Virginia
Co-authored papers 2
Columbia University
Co-authored papers 2
University of Toronto
Co-authored papers 2
Central China Normal University
Co-authored papers 2
University of Toronto
Co-authored papers 2
Argonne National Laboratory
Co-authored papers 2
Institut National de la Recherche Scientifique (INRS), Universite du Quebec
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Rensselaer Polytechnic Institute
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University of South Carolina, Michigan State University
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Dana-Farber Cancer Institute
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University of Oxford
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Kangwon National University College of Medicine
Co-authored papers 2
School of Public Health, Capital Medical University
Co-authored papers 1
Structural Genomics Consortium Karolinska Institute Stockholm Sweden.
Co-authored papers 1