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Author Details

Nino Devidze
Gladstone Institute of Neurological Disease
2003
41
28
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
32848093A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease.Sci Transl Med2020
29540553SIRT1 Deacetylates Tau and Reduces Pathogenic Tau Spread in a Mouse Model of Tauopathy.J Neurosci2018
28554556Dramatic elevation in urinary amino terminal titin fragment excretion quantified by immunoassay in Duchenne muscular dystrophy patients and in dystrophin deficient rodents.Neuromuscul Disord2017
25589773SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.J Neurosci2015
26615780DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice.Nat Commun2015
25933020Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models.PLoS One2015
25622143Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory.Nat Neurosci2015
25153994Tau overexpression impacts a neuroinflammation gene expression network perturbed in Alzheimer's disease.PLoS One2014
23332171Age-appropriate cognition and subtle dopamine-independent motor deficits in aged tau knockout mice.Neurobiol Aging2013
23525040Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β.Nat Neurosci2013
22079582Oxytocin, vasopressin and estrogen receptor gene expression in relation to social recognition in female mice.Physiol Behav2012
23029293Human P301L-mutant tau expression in mouse entorhinal-hippocampal network causes tau aggregation and presynaptic pathology but no cognitive deficits.PLoS One2012
22792368Hilar GABAergic interneuron activity controls spatial learning and memory retrieval.PLoS One2012
22869752Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.Proc Natl Acad Sci U S A2012
22541439Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model.Cell2012
21228179Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease.J Neurosci2011
21456014Molecular and neuroanatomical characterization of single neurons in the mouse medullary gigantocellular reticular nucleus.J Comp Neurol2011
21113149Reversing EphB2 depletion rescues cognitive functions in Alzheimer model.Nature2011
20053918Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein.J Neurosci2010
21040845Transsynaptic progression of amyloid-β-induced neuronal dysfunction within the entorhinal-hippocampal network.Neuron2010
20193744Estradiol regulation of lipocalin-type prostaglandin D synthase promoter activity: evidence for direct and indirect mechanisms.Neurosci Lett2010
19200066Estradiol modulates behavioral arousal and induces changes in gene expression profiles in brain regions involved in the control of vigilance.Eur J Neurosci2009
19776282NMDA receptor phosphorylation at a site affected in schizophrenia controls synaptic and behavioral plasticity.J Neurosci2009
18088362Voltage-dependent calcium channels in ventromedial hypothalamic neurones of postnatal rats: modulation by oestradiol and phenylephrine.J Neuroendocrinol2008
18957217Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease.Neuron2008
19045944Steady-state methadone effect on generalized arousal in male and female mice.Behav Neurosci2008
18480251Estradiol modulation of phenylephrine-induced excitatory responses in ventromedial hypothalamic neurons of female rats.Proc Natl Acad Sci U S A2008
18655890Steroidal/neuropeptide interactions in hypothalamus and amygdala related to social anxiety.Prog Brain Res2008
18374493Estrogen receptors alpha and beta mediate different aspects of the facilitatory effects of female cues on male risk taking.Psychoneuroendocrinology2008
18343595Presynaptic actions of opioid receptor agonists in ventromedial hypothalamic neurons in estrogen- and oil-treated female mice.Neuroscience2008
17498546Development of a sexually differentiated behavior and its underlying CNS arousal functions.Curr Top Dev Biol2007
17942628Histamine-induced excitatory responses in mouse ventromedial hypothalamic neurons: ionic mechanisms and estrogenic regulation.J Neurophysiol2007
16879168Oestradiol up-regulates glutamine synthetase mRNA and protein expression in the hypothalamus and hippocampus: implications for a role of hormonally responsive glia in amino acid neurotransmission.J Neuroendocrinol2006
17027700Functional genomics of sex hormone-dependent neuroendocrine systems: specific and generalized actions in the CNS.Prog Brain Res2006
16769096CNS arousal mechanisms bearing on sex and other biologically regulated behaviors.Physiol Behav2006
16942760Acute estradiol application increases inward and decreases outward whole-cell currents of neurons in rat hypothalamic ventromedial nucleus.Brain Res2006
15924555Female oxytocin gene-knockout mice, in a semi-natural environment, display exaggerated aggressive behavior.Genes Brain Behav2005
16230781Potentiation of genomic actions of estrogen by membrane actions in mcf-7 cells and the involvement of protein kinase C activation.Endocrine2005
16186484Sex and estrogenic effects on coexpression of mRNAs in single ventromedial hypothalamic neurons.Proc Natl Acad Sci U S A2005
12518068Estradiol differentially regulates lipocalin-type prostaglandin D synthase transcript levels in the rodent brain: Evidence from high-density oligonucleotide arrays and in situ hybridization.Proc Natl Acad Sci U S A2003
14638944Reduction of lipocalin-type prostaglandin D synthase in the preoptic area of female mice mimics estradiol effects on arousal and sex behavior.Proc Natl Acad Sci U S A2003
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Collaborators

Gladstone Institute of Neurological Disease, Gladstone Institutes
Co-authored papers 12
National Institute On Aging
Co-authored papers 8
Gladstone Institutes
Co-authored papers 2
Gladstone Institutes
Co-authored papers 2
Helen and Robert Appel Alzheimer's Disease Research Institute
Co-authored papers 2
O.W.) and University of Rochester Medical Center
Co-authored papers 2
Hartford Hospital Research Program, Hartford Hospital
Co-authored papers 1
University of Tennessee College of Medicine Chattanooga
Co-authored papers 1
University of California san francisco
Co-authored papers 1
Institute for Neurodegenerative Diseases, University of California San Francisco
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
Rush University Medical Center
Co-authored papers 1
Gladstone Institutes
Co-authored papers 1
Gladstone Institutes
Co-authored papers 1
Harvard Medical School
Co-authored papers 1
David Geffen School of Medicine, University of California los angeles
Co-authored papers 1
Dokkyo Medical University
Co-authored papers 1
Helen and Robert Appel Alzheimer's Disease Research Institute
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
UCSF Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 1
National Institute of Neurological, National Institutes of Health (NIH)
Co-authored papers 1
UCSF Medical School
Co-authored papers 1
Perelman School of Medicine at the University of Pennsylvania
Co-authored papers 1
Columbia University Medical Center
Co-authored papers 1
University of Pennsylvania
Co-authored papers 1
University of Alberta
Co-authored papers 1
Gladstone Institutes
Co-authored papers 1