Author details

Full Name

Kenneth C Bedi

Affiliation

ORCID

Career Start Year

2016

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36790929	Single-nucleus RNA sequencing in ischemic cardiomyopathy reveals common transcriptional profile underlying end-stage heart failure.	Cell Rep	2023
36317534	Noncanonical Form of ERAD Regulates Cardiac Hypertrophy.	Circulation	2023
37843128	Discovery adductomics provides a comprehensive portrait of tissue-, age- and sex-specific DNA modifications in rodents and humans.	Nucleic Acids Res	2023
37566108	Adult human cardiomyocyte mechanics in osteogenesis imperfecta.	Am J Physiol Heart Circ Physiol	2023
36734059	Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration.	Eur Heart J	2023
36856044	Myocardial Metabolomics of Human Heart Failure With Preserved Ejection Fraction.	Circulation	2023
34856123	Quantitative subcellular acyl-CoA analysis reveals distinct nuclear metabolism and isoleucine-dependent histone propionylation.	Molecular Cell	2022
36172868	Aortic Cellular Diversity and Quantitative Genome-Wide Association Study Trait Prioritization Through Single-Nuclear RNA Sequencing of the Aneurysmal Human Aorta.	Arterioscler Thromb Vasc Biol	2022
36223763	Extra-cardiac BCAA catabolism lowers blood pressure and protects from heart failure.	Cell Metab	2022
35568254	Direct anabolic metabolism of three-carbon propionate to a six-carbon metabolite occurs inÂ vivo across tissues and species.	Journal of Lipid Research	2022
35433678	Transcriptional, Post-Transcriptional, and Post-Translational Mechanisms Rewrite the Tubulin Code During Cardiac Hypertrophy and Failure.	Front Cell Dev Biol	2022
35732739	Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy.	Nature	2022
35988357	Glutamine uptake and catabolism is required for myofibroblast formation and persistence.	J Mol Cell Cardiol	2022
35605036	Glutaminolysis is Essential for Myofibroblast Persistence and In Vivo Targeting Reverses Fibrosis and Cardiac Dysfunction in Heart Failure.	Circulation	2022
36776621	Integrated landscape of cardiac metabolism in end-stage human nonischemic dilated cardiomyopathy.	Nat Cardiovasc Res	2022
34731015	Truncated titin proteins in dilated cardiomyopathy.	Sci Transl Med	2021
33529599	Pathogenic LMNA variants disrupt cardiac lamina-chromatin interactions and de-repress alternative fate genes.	Cell Stem Cell	2021
33715387	S-Nitrosylation of Histone Deacetylase 2 by Neuronal Nitric Oxide Synthase as a Mechanism of Diastolic Dysfunction.	Circulation	2021
33301345	Circadian Pattern of Ion Channel Gene Expression in Failing Human Hearts.	Circ Arrhythm Electrophysiol	2021
33347674	Pulmonary artery pulsatility index predicts right ventricular myofilament dysfunction in advanced human heart failure.	Eur J Heart Fail	2021
33118835	Myocardial Gene Expression Signatures in Human Heart Failure With Preserved Ejection Fraction.	Circulation	2021
34857921	Nuclear deformation guides chromatin reorganization in cardiac development and disease.	Nat Biomed Eng	2021
30903134	C-type natriuretic peptide co-ordinates cardiac structure and function.	Eur Heart J	2020
32403949	Transcriptional and Cellular Diversity of the Human Heart.	Circulation	2020
31941365	Microtubules Increase Diastolic Stiffness in Failing Human Cardiomyocytes and Myocardium.	Circulation	2020
32272864	Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes.	Circ Res	2020
33155827	Epigenetic Analyses of Human Left Atrial Tissue Identifies Gene Networks Underlying Atrial Fibrillation.	Circ Genom Precis Med	2020
33134326	Noncanonical WNT Activation in Human Right Ventricular Heart Failure.	Front Cardiovasc Med	2020
32511660	Myocyte Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2 mediated myocarditis.	medRxiv	2020
31424556	Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease.	J Pathol	2019
31723271	Author Correction: Targeting cardiac fibrosis with engineered T cells.	Nature	2019
31511695	Targeting cardiac fibrosis with engineered T cells.	Nature	2019
30762586	Targeting MRTF/SRF in CAP2-dependent dilated cardiomyopathy delays disease onset.	JCI Insight	2019
31484822	Cardiomyocyte d-dopachrome tautomerase protects against heart failure.	JCI Insight	2019
29892068	Suppression of detyrosinated microtubules improves cardiomyocyte function in human heart failure.	Nat Med	2018
28882819	Cardiomyocyte-Specific Telomere Shortening is a Distinct Signature of Heart Failure in Humans.	J Am Heart Assoc	2017
26819374	Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure.	Circulation	2016
26998524	Mitochondrial protein hyperacetylation in the failing heart.	JCI Insight	2016