Author details

Full Name

Richard M Higashi

Affiliation

ORCID

Career Start Year

1978

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37512481	Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer.		2023
37992808	Metabolic reprogramming driven by EZH2 inhibition depends on cell-matrix interactions.		2023
37550596	Asparagine restriction enhances CD8 T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response.		2023
36005633	A Micro-Scale Analytical Method for Determining Glycogen Turnover by NMR and FTMS.	Metabolites	2022
36223837	Ultrahigh resolution MS/MS-based reconstruction of metabolic networks in mammalian cells reveals changes for selenite and arsenite action.	Journal of Biological Chemistry	2022
36150727	Polarization and Î²-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.	Journal of Immunology	2022
34709178	6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function.	eLife	2021
33805301	NMR Methods for Determining Lipid Turnover via Stable Isotope Resolved Metabolomics.	Metabolites	2021
33482055	An Ion Chromatography-Ultrahigh-Resolution-MS/Data-Independent High-Resolution MS Method for Stable Isotope-Resolved Metabolomics Reconstruction of Central Metabolic Networks.	Analytical Chemistry	2021
33691103	Blockade of 6-phosphogluconate dehydrogenase generates CD8 effector TÂ cells with enhanced anti-tumor function.	Cell Reports	2021
34406120	Innate immune activation by checkpoint inhibition in human patient-derived lung cancer tissues.	eLife	2021
34556237	Rapid analysis of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) isotopologues in stable isotope-resolved metabolomics (SIRM) using direct infusion nanoelectrospray ultra-high-resolution Fourier transform mass spectrometry (DI-nESI-UHR-FTMS).	Analytica Chimica Acta	2021
32549391	Resolving Metabolic Heterogeneity in Experimental Models of the Tumor Microenvironment from a Stable Isotope Resolved Metabolomics Perspective.	Metabolites	2020
32019928	Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase.	Nat Commun	2020
31964922	Differential Abundance Analysis with Bayes Shrinkage Estimation of Variance (DASEV) for Zero-Inflated Proteomic and Metabolomic Data.	Scientific Reports	2020
31893378	Software Supporting a Workflow of Quantitative Dynamic Flux Maps Estimation in Central Metabolism from SIRM Experimental Data.	Methods in Molecular Biology	2020
32215288	Metabolic reprogramming in tumors: Contributions of the tumor microenvironment.	Genes and Diseases	2020
32483395	Applications of Chromatography-Ultra High-Resolution MS for Stable Isotope-Resolved Metabolomics (SIRM) Reconstruction of Metabolic Networks.	TrAC - Trends in Analytical Chemistry	2020
31409459	Improved segmented-scan spectral stitching for stable isotope resolved metabolomics (SIRM) by ultra-high-resolution Fourier transform mass spectrometry.	Analytica Chimica Acta	2019
32523238	NMR and MS-based Stable Isotope-Resolved Metabolomics and Applications in Cancer Metabolism.	TrAC - Trends in Analytical Chemistry	2019
31114017	Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes.	British Journal of Cancer	2019
31337706	<i>De novo</i> synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues.	J Biol Chem	2019
31347110	Quantification of Isotopologues of Amino Acids by Multiplexed Stable Isotope-Resolved Metabolomics Using Ultrahigh-Resolution Mass Spectrometry Coupled with Direct Infusion.	Methods in Molecular Biology	2019
31298457	Inhibition of Anaplerotic Glutaminolysis Underlies Selenite Toxicity in Human Lung Cancer.	Proteomics	2019
30830465	Towards quality assurance and quality control in untargeted metabolomics studies.	Metabolomics	2019
30830442	New methods to identify high peak density artifacts in Fourier transform mass spectra and to mitigate their effects on high-throughput metabolomic data analysis.	Metabolomics	2018
30292300	Exosomal lipids for classifying early and late stage non-small cell lung cancer.	Analytica Chimica Acta	2018
29523684	Acute loss of iron-sulfur clusters results in metabolic reprogramming and generation of lipid droplets in mammalian cells.	Journal of Biological Chemistry	2018
29078251	Selenium toxicity to survival and reproduction of Collembola and Enchytraeids in a sandy loam soil.	Environmental Toxicology and Chemistry	2018
29359211	Correction: Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS.	Analyst	2018
28163219	Probing the metabolic phenotype of breast cancer cells by multiple tracer stable isotope resolved metabolomics.	Metabolic Engineering	2017
28592486	Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM).	Journal of Biological Chemistry	2017
28576319	Chloroformate derivatization for tracing the fate of Amino acids in cells and tissues by multiple stable isotope resolved metabolomics (mSIRM).	Analytica Chimica Acta	2017
29158483	Noninvasive liquid diet delivery of stable isotopes into mouse models for deep metabolic network tracing.	Nat Commun	2017
29192912	Quantitative profiling of carbonyl metabolites directly in crude biological extracts using chemoselective tagging and nanoESI-FTMS.	Analyst	2017
27489532	Preclinical models for interrogating drug action in human cancers using Stable Isotope Resolved Metabolomics (SIRM).	Metabolomics	2016
27193687	An obligatory role for neurotensin in high-fat-diet-induced obesity.	Nature	2016
27183653	Correction: Dectin-1 Activation by a Natural Product Î²-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype.	Journal of Immunology	2016
27158639	Stable Isotope Resolved Metabolomics Studies TIssue Slices.	Bio-protocol	2016
26467476	Metabolomics Workbench: An international repository for metabolomics data and metadata, metabolite standards, protocols, tutorials and training, and analysis tools.	Nucleic Acids Res	2016
27551682	Distinctly perturbed metabolic networks underlie differential tumor tissue damages induced by immune modulator Î²-glucan in a two-case ex vivo non-small-cell lung cancer study.	Cold Spring Harbor molecular case studies	2016
26453753	Dectin-1 Activation by a Natural Product Î²-Glucan Converts Immunosuppressive Macrophages into an M1-like Phenotype.	Journal of Immunology	2015
25616249	Chemoselective detection and discrimination of carbonyl-containing compounds in metabolite mixtures by 1H-detected 15N nuclear magnetic resonance.	Magnetic Resonance in Chemistry	2015
25607840	Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation.	Journal of Clinical Investigation	2015
24957098	Knockdown of malic enzyme 2 suppresses lung tumor growth, induces differentiation and impacts PI3K/AKT signaling.	Sci Rep	2014
25270929	Stable isotope-labeled tracers for metabolic pathway elucidation by GC-MS and FT-MS.	Methods in Molecular Biology	2014
24374065	Ether bridge formation in loline alkaloid biosynthesis.	Phytochemistry	2014
24726384	Targeting lactate dehydrogenase--a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells.		2014
24858467	Profiling thiol metabolites and quantification of cellular glutathione using FT-ICR-MS spectrometry.	Analytical and Bioanalytical Chemistry	2014
22225880	Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells.	Cell Metab	2012