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Author Details

Hao Shao
Department of Pharmaceutical Chemistry, University of California San Francisco
2015
36
18
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36264168N-myc-Mediated Translation Control Is a Therapeutic Vulnerability in Medulloblastoma.Cancer Res2023
37791314An Unbiased Screen Identified the Hsp70-BAG3 Complex as a Regulator of Myosin-Binding Protein C3.JACC Basic Transl Sci2023
36975020A patent review of cyclin-dependent kinase 7 (CDK7) inhibitors (2018-2022).Expert Opin Ther Pat2023
37293102Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly.bioRxiv2023
35108506Selective vulnerabilities in the proteostasis network of castration-resistant prostate cancer.Cell Chem Biol2022
35830852A campaign targeting a conserved Hsp70 binding site uncovers how subcellular localization is linked to distinct biological activities.Cell Chem Biol2022
35853457Allosteric HSP70 inhibitors perturb mitochondrial proteostasis and overcome proteasome inhibitor resistance in multiple myeloma.Cell Chem Biol2022
34019840Adhesion-mediated mechanosignaling forces mitohormesis.Cell Metab2021
33854069Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice.Nat Commun2021
33839251Inhibitors of heat shock protein 70 (Hsp70) with enhanced metabolic stability reduce tau levels.Bioorg Med Chem Lett2021
31509197Individualized management of genetic diversity in Niemann-Pick C1 through modulation of the Hsp70 chaperone system.Hum Mol Genet2020
34123282Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells.Chem Sci2020
31952963Neutral analogs of the heat shock protein 70 (Hsp70) inhibitor, JG-98.Bioorg Med Chem Lett2020
32458889Differential scanning fluorimetry (DSF) screen to identify inhibitors of Hsp60 protein-protein interactions.Org Biomol Chem2020
32427588Inhibition of DNAJ-HSP70 interaction improves strength in muscular dystrophy.J Clin Invest2020
32291414Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability.Oncogene2020
32255605A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography.ACS Chem Biol2020
32156782Mortalin (HSPA9) facilitates <i>BRAF</i>-mutant tumor cell survival by suppressing ANT3-mediated mitochondrial membrane permeability.Sci Signal2020
30673613Zika Virus Dependence on Host Hsp70 Provides a Protective Strategy against Infection and Disease.Cell Rep2019
30213856Inhibitors and chemical probes for molecular chaperone networks.J Biol Chem2019
31395886Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.Nat Commun2019
31591399Author Correction: Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor.Nat Commun2019
28970360Heat Shock Protein 70 (Hsp70) Suppresses RIP1-Dependent Apoptotic and Necroptotic Cascades.Mol Cancer Res2018
29875314HSC70 is a chaperone for wild-type and mutant cardiac myosin binding protein C.JCI Insight2018
29953808Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70).J Med Chem2018
30111643KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice.Sci Transl Med2018
30372610A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein Interactions.ACS Chem Biol2018
29414793High-throughput screen for inhibitors of protein-protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex.J Biol Chem2018
29661622Rational design and screening of peptide-based inhibitors of heat shock factor 1 (HSF1).Bioorg Med Chem2018
29764864Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer.Cancer Res2018
29255093X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition.J Biol Chem2018
27013001Allosteric heat shock protein 70 inhibitors block hepatitis C virus assembly.Int J Antimicrob Agents2016
27503927Anticancer Effects of Targeting Hsp70 in Tumor Stromal Cells.Cancer Res2016
27434096Protein Cross-Linking Capillary Electrophoresis for Protein-Protein Interaction Analysis.Anal Chem2016
27072701Targeting Allosteric Control Mechanisms in Heat Shock Protein 70 (Hsp70).Curr Top Med Chem2016
27087913Concise Synthesis of Spergualin-Inspired Molecules With Broad-Spectrum Antibiotic Activity.Medchemcomm2015
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Collaborators

Jason E Gestwicki
Institute for Neurodegenerative Diseases, University of California San Francisco
Co-authored papers 35
Eric Tse
School of Clinical Medicine, University of Hong Kong
Co-authored papers 2
Jonathan S Weissman
Whitehead Institute for Biomedical Research
Co-authored papers 2
Chakrapani Kalyanaraman
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 2
Matthew P Jacobson
Department of Pharmaceutical Chemistry, University of California san francisco
Co-authored papers 2
Daniel R Southworth
The Institute for Neurodegenerative Diseases, University of California San Francisco
Co-authored papers 2
Giorgio Colombo
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Co-authored papers 2
Judith Frydman
Stanford University
Co-authored papers 2
Luke A Gilbert
Arc Institute
Co-authored papers 2
Daniel K Nomura
University of California berkeley
Co-authored papers 1
Youngho Seo
University of California san francisco
Co-authored papers 1
Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 1
Chao Wang
Gladstone Institutes
Co-authored papers 1
Marc K Hellerstein
University of California berkeley
Co-authored papers 1
Davide Ruggero
University of California San Francisco
Co-authored papers 1
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The University of Texas MD Anderson Cancer Center
Co-authored papers 1
Stefan Homentcovschi
Howard Hughes Medical Institute, University of California Berkeley
Co-authored papers 1
Joanna J Phillips
University of California san francisco
Co-authored papers 1
Li Gan
Helen and Robert Appel Alzheimer's Disease Research Institute
Co-authored papers 1
Greg A Timblin
University of California Berkeley
Co-authored papers 1
Breanna Ford
University of California berkeley
Co-authored papers 1
Jose Antonio Rodriguez
University of the Basque Country (UPV/EHU)
Co-authored papers 1
Johanna Ten Hoeve
California Nanosystems Institute, University of California los angeles
Co-authored papers 1
Florian Markowetz
CRUK Cambridge Institute, University of Cambridge
Co-authored papers 1
Spencer C Behr
University of California san francisco
Co-authored papers 1
Alicia L Richards
University of Wisconsin-Madison
Co-authored papers 1
Peter Dongmin Sohn
Gladstone Institutes
Co-authored papers 1
William A Weiss
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Release 1.2