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Author Details

Stephan Grzesiek
University of Basel
1986
142
52
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37244255A key GPCR phosphorylation motif discovered in arrestin2â¿¿CCR5 phosphopeptide complexes.Mol Cell2023
37553040The key role of glutamine for protein expression and isotopic labeling in insect cells.J Biol Chem2023
36394272Nanobody GPS by PCS: An Efficient New NMR Analysis Method for G Protein Coupled Receptors and Other Large Proteins.J Am Chem Soc2022
37905178Imatinib disassembles the regulatory core of Abelson kinase by binding to its ATP site and not by binding to its myristoyl pocket.Magn Reson (Gott)2022
35623699Preparation of a stable CCL5·CCR5·G<sub>i</sub> signaling complex for Cryo-EM analysis.Methods Cell Biol2022
35953642Filling of a water-free void explains the allosteric regulation of the β<sub>1</sub>-adrenergic receptor by cholesterol.Nat Chem2022
36257909Correspondence on "Synergy and Antagonism between Allosteric and Active-Site Inhibitors of Abl Tyrosine Kinase".Angew Chem Int Ed Engl2022
33501610Efficient production of a functional G protein-coupled receptor in E. coli for structural studies.J Biomol NMR2021
32371991A high-resolution description of β<sub>1</sub>-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR.Nat Commun2020
31980264Versatile modules enable automated multi-column purifications on the ÿKTA pure chromatography system.J Chromatogr A2020
32611811Intercepting second-messenger signaling by rationally designed peptides sequestering c-di-GMP.Proc Natl Acad Sci U S A2020
30545941Deuterium induces a distinctive <i>Escherichia coli</i> proteome that correlates with the reduction in growth rate.J Biol Chem2019
31396681Rapid determination of general cell status, cell viability, and optimal harvest time in eukaryotic cell cultures by impedance flow cytometry.Appl Microbiol Biotechnol2019
31564099High Pressure Shifts the β<sub>1</sub>-Adrenergic Receptor to the Active Conformation in the Absence of G Protein.J Am Chem Soc2019
29319304ATP Site Ligands Determine the Assembly State of the Abelson Kinase Regulatory Core via the Activation Loop Conformation.J Am Chem Soc2018
29687312Production of isotope-labeled proteins in insect cells for NMR.J Biomol NMR2018
29091032Cyclic di-GMP differentially tunes a bacterial flagellar motor through a novel class of CheY-like regulators.Elife2017
26840483Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor.Nature2016
26632648A Rigorous and Efficient Method To Reweight Very Large Conformational Ensembles Using Average Experimental Data and To Determine Their Relative Information Content.J Chem Theory Comput2016
27566405Comprehensive structural and dynamical view of an unfolded protein from the combination of single-molecule FRET, NMR, and SAXS.Proc Natl Acad Sci U S A2016
25794270Backbone hydration determines the folding signature of amino acid residues.J Am Chem Soc2015
26234369Unraveling the complexity of protein backbone dynamics with combined (13)C and (15)N solid-state NMR relaxation measurements.Phys Chem Chem Phys2015
26070442An economic approach to efficient isotope labeling in insect cells using homemade 15N-, 13C- and 2H-labeled yeast extracts.J Biomol NMR2015
25381931Solid-state NMR of a protein in a precipitated complex with a full-length antibody.J Am Chem Soc2014
25489067Structural basis and dynamics of multidrug recognition in a minimal bacterial multidrug resistance system.Proc Natl Acad Sci U S A2014
23284170High-pressure NMR reveals close similarity between cold and alcohol protein denaturation in ubiquitin.Proc Natl Acad Sci U S A2013
24314089Characterization of structure, dynamics, and detergent interactions of the anti-HIV chemokine variant 5P12-RANTES.Biophys J2013
24126912WhiB7, an Fe-S-dependent transcription factor that activates species-specific repertoires of drug resistance determinants in actinobacteria.J Biol Chem2013
24191057NMR reveals the allosteric opening and closing of Abelson tyrosine kinase by ATP-site and myristoyl pocket inhibitors.Proc Natl Acad Sci U S A2013
23843149Kinase in motion: insights into the dynamic nature of p38α by high-pressure NMR spectroscopic studies.Chembiochem2013
23229639Biophysical and structural investigation of bacterially expressed and engineered CCR5, a G protein-coupled receptor.J Biomol NMR2013
22142443Oligomer formation of the bacterial second messenger c-di-GMP: reaction rates and equilibrium constants indicate a monomeric state at physiological concentrations.J Am Chem Soc2012
23261601Enhancement of anti-HIV-1 activity by hot spot evolution of RANTES-derived peptides.Chem Biol2012
22988852Residual dipolar couplings measured in unfolded proteins are sensitive to amino-acid-specific geometries as well as local conformational sampling.Biochem Soc Trans2012
22955930In support of the BMRB.Nat Struct Mol Biol2012
22914191Key stabilizing elements of protein structure identified through pressure and temperature perturbation of its hydrogen bond network.Nat Chem2012
22493731Monocytes contribute to differential immune pressure on R5 versus X4 HIV through the adipocytokine visfatin/NAMPT.PLoS One2012
22309138Sequence-specific mapping of the interaction between urea and unfolded ubiquitin from ensemble analysis of NMR and small angle scattering data.J Am Chem Soc2012
21310957Solution structure of the PilZ domain protein PA4608 complex with cyclic di-GMP identifies charge clustering as molecular readout.J Biol Chem2011
22033481Structure and dynamics of a stabilized coiled-coil domain in the P-TEFb regulator Hexim1.J Mol Biol2011
21846933Structure, dynamics, lipid binding, and physiological relevance of the putative GTPase-binding domain of Dictyostelium formin C.J Biol Chem2011
21923156Site-specific measurement of slow motions in proteins.J Am Chem Soc2011
20072125Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors.Nature2010
20507068Measurement of site-specific 13C spin-lattice relaxation in a crystalline protein.J Am Chem Soc2010
20155903Side-chain chi(1) conformations in urea-denatured ubiquitin and protein G from (3)J coupling constants and residual dipolar couplings.J Am Chem Soc2010
20210365A flexible bipartite coiled coil structure is required for the interaction of Hexim1 with the P-TEFB subunit cyclin T1.Biochemistry2010
20000836Ensemble calculations of unstructured proteins constrained by RDC and PRE data: a case study of urea-denatured ubiquitin.J Am Chem Soc2010
19748338Quantitative determination of the conformational properties of partially folded and intrinsically disordered proteins using NMR dipolar couplings.Structure2009
19785413DOTA-M8: An extremely rigid, high-affinity lanthanide chelating tag for PCS NMR spectroscopy.J Am Chem Soc2009
19716691From biomolecular structure to functional understanding: new NMR developments narrow the gap.Curr Opin Struct Biol2009
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Collaborators

National Institutes of Health
Co-authored papers 22
Technische Universitat Munchen
Co-authored papers 11
Biocon Research Limited - SEZ Unit
Co-authored papers 8
Leicester Institute of Structural and Chemical Biology, University of Leicester
Co-authored papers 7
Co-authored papers 2
University of Pittsburgh
Co-authored papers 2
University of California San Francisco
Co-authored papers 1
University of Illinois
Co-authored papers 1
and Center for Structural Biology, Vanderbilt University
Co-authored papers 1
Technische Universitat Munchen (TUM)
Co-authored papers 1
University of Bristol
Co-authored papers 1
The University of Manchester
Co-authored papers 1
Rutgers University
Co-authored papers 1
Center for Integrated Protein Science, Technische Universitat Munchen
Co-authored papers 1
Leicester Institute of Structural and Chemical Biology, University of Leicester
Co-authored papers 1
Institut fur Pysikalische Biologie, Heinrich Heine University Dusseldorf
Co-authored papers 1
University of Texas Southwestern Medical Center
Co-authored papers 1
The University of Sheffield
Co-authored papers 1
Institute of Systems, The University of Liverpool
Co-authored papers 1
University of California at San Francisco
Co-authored papers 1
Institute of Integrative Biology, University of Liverpool
Co-authored papers 1
Columbia University
Co-authored papers 1
Zernike Institute for Advanced Materials, University of Groningen
Co-authored papers 1
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University of Oxford
Co-authored papers 1
The Medical Research Council Biomedical NMR Centre, The Francis Crick Institute
Co-authored papers 1
University of Cambridge
Co-authored papers 1
Carnegie Mellon University
Co-authored papers 1
Imperial College London
Co-authored papers 1
Carnegie Mellon University
Co-authored papers 1