Author details

Full Name

A S Acharya

Affiliation

ORCID

Career Start Year

1973

Papers

133

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
34680105	Quercetin Completely Ameliorates Hypoxia-Reoxygenation-Induced Pathophysiology Severity in NY1DD Transgenic Sickle Mice: Intrinsic Mild Steady State Pathophysiology of the Disease in NY1DD Is Also Reversed.	Biomolecules	2021
33980829	INI1/SMARCB1 Rpt1 domain mimics TAR RNA in binding to integrase to facilitate HIV-1 replication.	Nat Commun	2021
34134586	First Report of Compound Heterozygosity for Hb S (: c.20A>T) and Hb Haringey (: c.131A>G).	Hemoglobin	2021
30663492	Semisynthetic supra plasma expanders: a new class of therapeutics to improve microcircualtion in sickle cell anaemia.	Artif Cells Nanomed Biotechnol	2019
28278759	Influence of semisynthetic modification of the scaffold of a contact domain of HbS on polymerization: role of flexible surface topology in polymerization inhibition.	Journal of Biomolecular Structure and Dynamics	2018
28186661	Brain neurochemical and hemodynamic findings in the NY1DD mouse model of mild sickle cell disease.	NMR Biomed	2017
27261671	Computational modeling of Repeat1 region of INI1/hSNF5: An evolutionary link with ubiquitin.	Protein Science	2016
24597567	PEGylation of Î±Î±-Hb using succinimidyl propionic acid PEG 5K: Conjugation chemistry and PEG shell structure dictate respectively the oxygen affinity and resuscitation fluid like properties of PEG Î±Î±-Hbs.	Artif Cells Nanomed Biotechnol	2015
25871869	Supra-plasma expanders: the future of treating blood loss and anemia without red cell transfusions?	J Infus Nurs	2015
25350267	Replacing the Transfusion of 1-2 Units of Blood with Plasma Expanders that Increase Oxygen Delivery Capacity: Evidence from Experimental Studies.	J Funct Biomater	2014
23687928	Semisynthetic hybrid biopolymers for non-pharmacological intervention of the microcirculation.	Curr Drug Metab	2013
22554380	Plasma expander and blood storage effects on capillary perfusion in transfusion after hemorrhage.	Transfusion	2013
21623695	Packing density of the PEG-shell in PEG-albumins: PEGylation induced viscosity and COP are inverse correlate of packing density.	Artif Cells Blood Substit Immobil Biotechnol	2012
22505638	PEG-albumin supraplasma expansion is due to increased vessel wall shear stress induced by blood viscosity shear thinning.	Am J Physiol Heart Circ Physiol	2012
22720043	PEG-albumin plasma expansion increases expression of MCP-1 evidencing increased circulatory wall shear stress: an experimental study.	PLoS One	2012
20653337	Increased inter dimeric interaction of oxy hemoglobin is necessary for attenuation of reductive pegylation promoted dissociation of tetramer.		2011
20813980	Tissue oxidative metabolism after extreme hemodilution with PEG-conjugated hemoglobin.	J Appl Physiol (1985)	2010
20715854	Bis[2-(3-carboxyphenoxy)carbonylethyl]phosphinic acid (m-BCCEP): a novel affinity cross-linking reagent for the beta-cleft modification of human hemoglobin.	Bioconjugate Chemistry	2010
19922165	Induced plasma expander-like properties as a function of PEG-chains on extension arm facilitated PEGylation of albumin: "mushroom to brush-like" conformational transition of the PEG-albumin conjugate.		2009
19119852	PEGylation of Val-1(alpha) destabilizes the tetrameric structure of hemoglobin.	Biochemistry	2009
19653083	Hexa-thiocarbamoyl phenyl PEG5K Hb: vasoactivity and structure: influence of rigidity of the conjugation linkage on the PEGylation induced plasma expander-like solution properties of PEG-Hb adducts.	Protein J	2009
19842622	Extension arm facilitated pegylation of alphaalpha-hemoglobin with modifications targeted exclusively to amino groups: functional and structural advantages of free Cys-93(beta) in the PEG-Hb adduct.	Bioconjugate Chemistry	2009
18452721	Non-conservative surface decoration of hemoglobin: influence of neutralization of positive charges at PEGylation sites on molecular and functional properties of PEGylated hemoglobin.		2008
19085194	Role of extension arm in PEG-Hb conjugates on the stability of the tetramer: non-conservative EAF maleimide thio-PEG mediated PEGylation.		2008
18158909	Analysis of functionalization of methoxy-PEG as maleimide-PEG.	Analytical Biochemistry	2008
18572961	PEGylation of human serum albumin: reaction of PEG-phenyl-isothiocyanate with protein.	Bioconjugate Chemistry	2008
18621463	Volume resuscitation from hemorrhagic shock with albumin and hexaPEGylated human serum albumin.	Resuscitation	2008
18423033	Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130/0.4: a microvascular perspective.	Crit Care	2008
18808150	Autoxidation of the site-specifically PEGylated hemoglobins: role of the PEG chains and the sites of PEGylation in the autoxidation.	Biochemistry	2008
17049048	Influence of intramolecular cross-links on the molecular, structural and functional properties of PEGylated haemoglobin.	Biochem J	2007
17381072	Combining the influence of two low O2 affinity-inducing chemical modifications of the central cavity of hemoglobin.	Biochemistry	2007
17425516	Non-hypertensive tetraPEGylated canine haemoglobin: correlation between PEGylation, O2 affinity and tissue oxygenation.	Biochem J	2007
17364475	Thiolation mediated pegylation platform to generate functional universal red blood cells.		2007
17364468	Molecular aspects of the high oxygen affinity of non-hypertensive hexa pegylated hemoglobin, [(SP-PEG5K)(6)-Hb].	Artif Cells Blood Substit Immobil Biotechnol	2007
17973182	HbS-Savaria: the anti-polymerization effect of a single mutation in human alpha-chains.	Protein Journal	2007
16374164	Microvascular effects following treatment with polyethylene glycol-albumin in lipopolysaccharide-induced endotoxemia.	Crit Care Med	2006
17131194	Pair-wise interactions of polymerization inhibitory contact site mutations of hemoglobin-S.	Protein J	2006
16818412	Molecular modeling studies of surface decoration of hemoglobin by maleimide PEG.		2006
16857991	Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers.	Blood	2006
16718519	Extension arm facilitated PEGylation of hemoglobin: correlation of the properties with the extent of PEGylation.	Protein Journal	2006
16111474	Influence of the chemistry of conjugation of poly(ethylene glycol) to Hb on the oxygen-binding and solution properties of the PEG-Hb conjugate.	Biochemical Journal	2005
15988323	Early difference in tissue pH and microvascular hemodynamics in hemorrhagic shock resuscitation using polyethylene glycol-albumin- and hydroxyethyl starch-based plasma expanders.	Shock	2005
16152690	Enhanced molecular volume of conservatively pegylated Hb: (SP-PEG5K)6-HbA is non-hypertensive.	Artif Cells Blood Substit Immobil Biotechnol	2005
16096719	Conjugation of multiple copies of polyethylene glycol to hemoglobin facilitated through thiolation: influence on hemoglobin structure and function.	Protein J	2005
15752155	Surface decoration of red blood cells with maleimidophenyl-polyethylene glycol facilitated by thiolation with iminothiolane: an approach to mask A, B, and D antigens to generate universal red blood cells.	Transfusion	2005
15096052	Domain-specific effector interactions within the central cavity of human adult hemoglobin in solution and in porous sol-gel matrices: evidence for long-range communication pathways.	Biochemistry	2004
15194702	WITHDRAWN: PEGylated hemoglobin: Role of surface configuration of PEG for the modulation of hemoglobin vasoactivity.	J Biol Chem	2004
15191899	Microvascular PO2 during extreme hemodilution with hemoglobin site specifically PEGylated at Cys-93(beta) in hamster window chamber.	Am J Physiol Heart Circ Physiol	2004
15096632	Hemoglobin Einstein: semisynthetic deletion in the B-helix of the alpha-chain.	Protein Sci	2004
12643758	Site-specific PEGylation of hemoglobin at Cys-93(beta): correlation between the colligative properties of the PEGylated protein and the length of the conjugated PEG chain.	Bioconjug Chem	2003