Author details

Full Name

Xiaoquan Wen

Affiliation

ORCID

Career Start Year

2004

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36608684	Probabilistic integration of transcriptome-wide association studies and colocalization analysis identifies key molecular pathways of complex traits.		2023
37873414	GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.	medRxiv	2023
37279733	JUMP: replicability analysis of high-throughput experiments with applications to spatial transcriptomic studies.		2023
36646693	Analysis of transcriptional changes in the immune system associated with pubertal development in a longitudinal cohort of children with asthma.		2023
37442575	Genetic control of the dynamic transcriptional response to immune stimuli and glucocorticoids at single-cell resolution.		2023
35313584	Genetic control of the dynamic transcriptional response to immune stimuli and glucocorticoids at single cell resolution.		2022
35523146	Analyzing and reconciling colocalization and transcriptome-wide association studies from the perspective of inferential reproducibility.	American Journal of Human Genetics	2022
36055244	Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk.	Am J Hum Genet	2022
34818542	Interspecies variation in hominid gut microbiota controls host gene regulation.	Cell Reports	2021
33585870	Revisiting the genome-wide significance threshold for common variant GWAS.	G3: Genes, Genomes, Genetics	2021
33988505	Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions.	eLife	2021
34142656	Psychosocial experiences modulate asthma-associated genes through gene-environment interactions.	eLife	2021
33499903	Exploiting the GTEx resources to decipher the mechanisms at GWAS loci.	Genome Biol	2021
33308443	Probabilistic colocalization of genetic variants from complex and molecular traits: promise and limitations.	Am J Hum Genet	2021
32627167	Structural factor equation models for causal network construction via directed acyclic mixed graphs.	Biometrics	2021
33320851	Integrating comprehensive functional annotations to boost power and accuracy in gene-based association analysis.	PLoS Genet	2020
31877118	Effects of MYBPC3 loss-of-function mutations preceding hypertrophic cardiomyopathy.	JCI insight	2020
31702789	BAGSE: a Bayesian hierarchical model approach for gene set enrichment analysis.		2020
33046893	Quantify and control reproducibility in high-throughput experiments.	Nature Methods	2020
32917697	PhenomeXcan: Mapping the genome to the phenome through the transcriptome.	Sci Adv	2020
32964524	Fine-mapping and QTL tissue-sharing information improves the reliability of causal gene identification.	Genetic Epidemiology	2020
32913075	Cell type-specific genetic regulation of gene expression across human tissues.	Science	2020
32912333	Impact of admixture and ancestry on eQTL analysis and GWAS colocalization in GTEx.	Genome Biol	2020
32912253	PTWAS: investigating tissue-relevant causal molecular mechanisms of complex traits using probabilistic TWAS analysis.		2020
31492806	Interpreting Coronary Artery Disease Risk Through Gene-Environment Interactions in Gene Regulation.	Genetics	2019
30864387	False discovery control for penalized variable selections with high-dimensional covariates.	Statistical Applications in Genetics and Molecular Biology	2018
29028988	QuASAR-MPRA: accurate allele-specific analysis for massively parallel reporter assays.		2018
30301895	Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients.	Nat Commun	2018
30061737	Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.	Nat Genet	2018
30254052	High-throughput characterization of genetic effects on DNA-protein binding and gene transcription.	Genome Research	2018
30057032	An eQTL Landscape of Kidney Tissue in Human Nephrotic Syndrome.	Am J Hum Genet	2018
29955180	Using an atlas of gene regulation across 44 human tissues to inform complex disease- and trait-associated variation.	Nat Genet	2018
28278150	Integrating molecular QTL data into genome-wide genetic association analysis: Probabilistic assessment of enrichment and colocalization.	PLoS Genetics	2017
28537254	Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants.	Nat Commun	2017
29023442	Environmental perturbations lead to extensive directional shifts in RNA processing.	PLoS Genetics	2017
27934696	High-throughput allele-specific expression across 250 environmental conditions.	Genome Research	2016
27236919	Efficient Integrative Multi-SNP Association Analysis via Deterministic Approximation of Posteriors.	American Journal of Human Genetics	2016
26962054	Perinatal Lead Exposure Alters Gut Microbiota Composition and Results in Sex-specific Bodyweight Increases in Adult Mice.	Toxicological Sciences	2016
26901046	Which Genetics Variants in DNase-Seq Footprints Are More Likely to Alter Binding?	PLoS Genetics	2016
27353450	The genetic regulatory signature of type 2 diabetes in human skeletal muscle.	Nat Commun	2016
26626624	Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture.	Am J Hum Genet	2015
25796429	Bayesian model comparison in genetic association analysis: linear mixed modeling and SNP set testing.	Biostatistics	2015
25906321	Cross-population joint analysis of eQTLs: fine mapping and functional annotation.	PLoS Genetics	2015
25480375	QuASAR: quantitative allele-specific analysis of reads.		2015
26510397	A high-throughput RNA-seq approach to profile transcriptional responses.	Scientific Reports	2015
24801060	The role of environmental heterogeneity in meta-analysis of gene-environment interactions with quantitative traits.	Genet Epidemiol	2014
26413181	BAYESIAN METHODS FOR GENETIC ASSOCIATION ANALYSIS WITH HETEROGENEOUS SUBGROUPS: FROM META-ANALYSES TO GENE-ENVIRONMENT INTERACTIONS.	Ann Appl Stat	2014
24350677	Bayesian model selection in complex linear systems, as illustrated in genetic association studies.	Biometrics	2014
23671422	A statistical framework for joint eQTL analysis in multiple tissues.	PLoS Genet	2013
21750684	Interactions between glucocorticoid treatment and cis-regulatory polymorphisms contribute to cellular response phenotypes.	PLoS Genet	2011