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Author Details

Ruth Nussinov
Sackler School of Medicine, Tel Aviv University
1980
750
101
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37978802Molecular mechanism of regulation of RhoA GTPase by phosphorylation of RhoGDI.Biophys J2024
37978802Molecular mechanism of regulation of RhoA GTPase by phosphorylation of RhoGDI.Biophys J2024
37524384Direct K-Ras Inhibitors to Treat Cancers: Progress, New Insights, and Approaches to Treat Resistance.Annu Rev Pharmacol Toxicol2024
37524384Direct K-Ras Inhibitors to Treat Cancers: Progress, New Insights, and Approaches to Treat Resistance.Annu Rev Pharmacol Toxicol2024
36369657Higher-order interactions of Bcr-Abl can broaden chronic myeloid leukemia (CML) drug repertoire.Protein Sci2023
36369657Higher-order interactions of Bcr-Abl can broaden chronic myeloid leukemia (CML) drug repertoire.Protein Sci2023
37946677Spatial Mechano-Signaling Regulation of GTPases through Non-Degradative Ubiquitination.Adv Sci (Weinh)2023
37935253Cancer and Autism: How PTEN Mutations Degrade Function at the Membrane and Isoform Expression in the Human Brain.J Mol Biol2023
37920394Protein conformational ensembles in function: roles and mechanisms.RSC Chem Biol2023
38085330SHP2 clinical phenotype, cancer, or RASopathies, can be predicted by mutant conformational propensities.Cell Mol Life Sci2023
37790340Cell cycle progression mechanisms: slower cyclin-D/CDK4 activation and faster cyclin-E/CDK2.bioRxiv2023
37871498Cell phenotypes can be predicted from propensities of protein conformations.Curr Opin Struct Biol2023
36910650Pathogen-driven cancers from a structural perspective: Targeting host-pathogen protein-protein interactions.Front Oncol2023
36907321AlphaFold, allosteric, and orthosteric drug discovery: Ways forward.Drug Discov Today2023
36580595Opinion: Protein folds vs. protein folding: Differing questions, different challenges.Proc Natl Acad Sci U S A2023
36573259Activation mechanisms of clinically distinct B-Raf V600E and V600K mutants.Cancer Commun (Lond)2023
36815703Strategy toward Kinase-Selective Drug Discovery.J Chem Theory Comput2023
36814845Graph embedding and Gaussian mixture variational autoencoder network for end-to-end analysis of single-cell RNA sequencing data.Cell Rep Methods2023
36759615Visualizing RNA conformational and architectural heterogeneity in solution.Nat Commun2023
36808143Pan-cancer clinical impact of latent drivers from double mutations.Commun Biol2023
36747841How PTEN mutations degrade function at the membrane and life expectancy of carriers of mutations in the human brain.bioRxiv2023
37124926Neurodevelopmental disorders, like cancer, are connected to impaired chromatin remodelers, PI3K/mTOR, and PAK1-regulated MAPK.Biophys Rev2023
37433832Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells.Commun Biol2023
36726377Small GTPase Ran: Depicting the nucleotide-specific conformational landscape of the functionally important C-terminus.Front Mol Biosci2023
37500946Author Correction: Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells.Commun Biol2023
38085330SHP2 clinical phenotype, cancer, or RASopathies, can be predicted by mutant conformational propensities.Cell Mol Life Sci2023
37920394Protein conformational ensembles in function: roles and mechanisms.RSC Chem Biol2023
37946677Spatial Mechano-Signaling Regulation of GTPases through Non-Degradative Ubiquitination.Adv Sci (Weinh)2023
37790340Cell cycle progression mechanisms: slower cyclin-D/CDK4 activation and faster cyclin-E/CDK2.bioRxiv2023
37935253Cancer and Autism: How PTEN Mutations Degrade Function at the Membrane and Isoform Expression in the Human Brain.J Mol Biol2023
37500946Author Correction: Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells.Commun Biol2023
37871498Cell phenotypes can be predicted from propensities of protein conformations.Curr Opin Struct Biol2023
37124926Neurodevelopmental disorders, like cancer, are connected to impaired chromatin remodelers, PI3K/mTOR, and PAK1-regulated MAPK.Biophys Rev2023
37433832Architectural basis for cylindrical self-assembly governing Plk4-mediated centriole duplication in human cells.Commun Biol2023
36815703Strategy toward Kinase-Selective Drug Discovery.J Chem Theory Comput2023
36814845Graph embedding and Gaussian mixture variational autoencoder network for end-to-end analysis of single-cell RNA sequencing data.Cell Rep Methods2023
36747841How PTEN mutations degrade function at the membrane and life expectancy of carriers of mutations in the human brain.bioRxiv2023
36580595Opinion: Protein folds vs. protein folding: Differing questions, different challenges.Proc Natl Acad Sci U S A2023
36808143Pan-cancer clinical impact of latent drivers from double mutations.Commun Biol2023
36910650Pathogen-driven cancers from a structural perspective: Targeting host-pathogen protein-protein interactions.Front Oncol2023
36907321AlphaFold, allosteric, and orthosteric drug discovery: Ways forward.Drug Discov Today2023
36573259Activation mechanisms of clinically distinct B-Raf V600E and V600K mutants.Cancer Commun (Lond)2023
36759615Visualizing RNA conformational and architectural heterogeneity in solution.Nat Commun2023
36726377Small GTPase Ran: Depicting the nucleotide-specific conformational landscape of the functionally important C-terminus.Front Mol Biosci2023
34628220Interpretable artificial intelligence and exascale molecular dynamics simulations to reveal kinetics: Applications to Alzheimer's disease.Curr Opin Struct Biol2022
35712080Neurodevelopmental disorders, immunity, and cancer are connected.iScience2022
36306797Deep generative molecular design reshapes drug discovery.Cell Rep Med2022
35651316The structural basis of BCR-ABL recruitment of GRB2 in chronic myelogenous leukemia.Biophys J2022
35508574The mechanism of activation of MEK1 by B-Raf and KSR1.Cell Mol Life Sci2022
36154343How has artificial intelligence impacted COVID-19 drug repurposing and what lessons have we learned?Expert Opin Drug Discov2022
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Collaborators

Co-authored papers 137
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Co-authored papers 116
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Co-authored papers 4
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Co-authored papers 4
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Co-authored papers 4
University of Virginia
Co-authored papers 4
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Weizmann Institute of Science
Co-authored papers 3
The Institute of Biomedical Sciences, East China Normal University
Co-authored papers 3
Co-authored papers 3
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The University of Kansas
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