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Author Details

Gye Won Han
Bridge Institute, University of Southern California
1991
166
54
PMIDPaper TitleJournal TitlePublished Year
36849514The activation mechanism and antibody binding mode for orphan GPR20.Cell Discov2023
36973264Structural insights into the human niacin receptor HCA2-G<sub>i</sub> signalling complex.Nat Commun2023
35977382GPCR Agonist-to-Antagonist Conversion: Enabling the Design of Nucleoside Functional Switches for the A<sub>2A</sub> Adenosine Receptor.J Med Chem2022
35840686Publisher Correction: Structural basis of GABA reuptake inhibition.Nature2022
35676483Structural basis of GABA reuptake inhibition.Nature2022
35817871Structural insight into apelin receptor-G protein stoichiometry.Nat Struct Mol Biol2022
35933788High ligand efficiency quinazoline compounds as novel A<sub>2A</sub> adenosine receptor antagonists.Eur J Med Chem2022
35917342Inhibition of the angiotensin II type 2 receptor AT<sub>2</sub>R is a novel therapeutic strategy for glioblastoma.Proc Natl Acad Sci U S A2022
34239071Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G<sub>s</sub>.Cell Res2021
34016973Structural insights on ligand recognition at the human leukotriene B4 receptor 1.Nat Commun2021
32139677Structural basis of ligand binding modes at the human formyl peptide receptor 2.Nat Commun2020
32076264Structural basis of ligand recognition and self-activation of orphan GPR52.Nature2020
33209312Harnessing the power of an X-ray laser for serial crystallography of membrane proteins crystallized in lipidic cubic phase.IUCrJ2020
33069069An orthogonal seryl-tRNA synthetase/tRNA pair for noncanonical amino acid mutagenesis in Escherichia coli.Bioorg Med Chem2020
33006884A Single Reactive Noncanonical Amino Acid is Able to Dramatically Stabilize Protein Structure.ACS Chem Biol2020
32555460Structural basis of the activation of a metabotropic GABA receptor.Nature2020
32152292Full-length human GLP-1 receptor structure without orthosteric ligands.Nat Commun2020
32327598Determination of the melanocortin-4 receptor structure identifies Ca<sup>2+</sup> as a cofactor for ligand binding.Science2020
30639103Crystal Structure of the Human Cannabinoid Receptor CB2.Cell2019
31811124Structural basis of ligand selectivity and disease mutations in cysteinyl leukotriene receptors.Nat Commun2019
31807708Elucidating the active δ-opioid receptor crystal structure with peptide and small-molecule agonists.Sci Adv2019
31801061Molecular Mechanism for Ligand Recognition and Subtype Selectivity of α<sub>2C</sub> Adrenergic Receptor.Cell Rep2019
31801060Structural Basis of the Diversity of Adrenergic Receptors.Cell Rep2019
31709066Toward G protein-coupled receptor structure-based drug design using X-ray lasers.IUCrJ2019
31181898A Single Reactive Noncanonical Amino Acid Is Able to Dramatically Stabilize Protein Structure.ACS Chem Biol2019
31633023Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs.Sci Adv2019
31048811Publisher Correction: Structural basis of ligand recognition at the human MT1 melatonin receptor.Nature2019
31019306Structural basis of ligand recognition at the human MT<sub>1</sub> melatonin receptor.Nature2019
31019305XFEL structures of the human MT<sub>2</sub> melatonin receptor reveal the basis of subtype selectivity.Nature2019
30573766Publisher Correction: Crystal structure of misoprostol bound to the labor inducer prostaglandin E<sub>2</sub> receptor.Nat Chem Biol2019
30510194Crystal structure of misoprostol bound to the labor inducer prostaglandin E<sub>2</sub> receptor.Nat Chem Biol2019
29290469Allosteric Coupling of Drug Binding and Intracellular Signaling in the A<sub>2A</sub> Adenosine Receptor.Cell2018
30135577Crystal structure of the Frizzled 4 receptor in a ligand-free state.Nature2018
29808000Structural basis for signal recognition and transduction by platelet-activating-factor receptor.Nat Struct Mol Biol2018
293981125-HT<sub>2C</sub> Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.Cell2018
29395784Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling.Structure2018
29307491Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.Cell2018
28636951Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV.Immunity2017
28440223Structural insights into the molecular mechanisms of myasthenia gravis and their therapeutic implications.Elife2017
28413876Generation of an Orthogonal Protein-Protein Interface with a Noncanonical Amino Acid.J Am Chem Soc2017
28379944Structural basis for selectivity and diversity in angiotensin II receptors.Nature2017
28678776Crystal structures of agonist-bound human cannabinoid receptor CB<sub>1</sub>.Nature2017
28514451Structure of the full-length glucagon class B G-protein-coupled receptor.Nature2017
28514449Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators.Nature2017
28513578Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand.Nat Commun2017
28528775Structural Basis for Apelin Control of the Human Apelin Receptor.Structure2017
28716900Structural insights into the extracellular recognition of the human serotonin 2B receptor by an antibody.Proc Natl Acad Sci U S A2017
27070998X-ray laser diffraction for structure determination of the rhodopsin-arrestin complex.Sci Data2016
27768894Crystal Structure of the Human Cannabinoid Receptor CB<sub>1</sub>.Cell2016
27926736Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists.Nature2016
  • 1 - 50 of 166

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Collaborators

Raymond C Stevens
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Qingping Xu
Argonne National Laboratory
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Ian A Wilson
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Co-authored papers 61
Mitchell D Miller
Rice University
Co-authored papers 60
Scott A Lesley
Merck & Co., Inc.
Co-authored papers 60
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Co-authored papers 60
Ashley M Deacon
Accelero Biostructures Inc., USA XPose Therapeutics Inc.
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Co-authored papers 59
Adam Godzik
University of California Riverside
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University of California Riverside School of Medicine
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University of California
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Merck & Co., Inc.
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Regeneron Pharmaceuticals, Inc.
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Edward Nigoghossian
Genomics Institute of the Novartis Research Foundation
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Henry van den Bedem
University of California San Francisco
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Daniel McMullan
Genomics Institute of the Novartis Research Foundation
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Herbert L Axelrod
Joint Center for Structural Genomics
Co-authored papers 50
Andrew T Morse
Co-authored papers 48
Sanjay Krishna
Institute of Science, Banaras Hindu University
Co-authored papers 47
Christopher L Rife
The Joint Center for Structural Genomics, Stanford University
Co-authored papers 47
Mark W Knuth
Joint Center for Structural Genomics
Co-authored papers 46
Kevin K Jin
Cardiovascular Institute, Stanford University School of Medicine
Co-authored papers 45
Thomas Clayton
Celgene/Bristol-Myers Squibb Corporation
Co-authored papers 44
Tamara Astakhova
Joint Center for Structural Genomics, University of California - San Diego
Co-authored papers 44
Lian Duan
Brown University
Co-authored papers 44
Dennis Carlton
Co-authored papers 43
Julie Feuerhelm
Co-authored papers 43
Linda Okach
Co-authored papers 42
Release 1.2