Author details

Full Name

Elizabeth A Komives

Affiliation

ORCID

Career Start Year

1983

Papers

191

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36854124	Capturing the Dynamic Conformational Changes of Human Isocitrate Dehydrogenase 1 (IDH1) upon Ligand and Metal Binding Using Hydrogen-Deuterium Exchange Mass Spectrometry.		2023
37607618	The autoactivation of human single-chain urokinase-type plasminogen activator (uPA).		2023
38095058	The multifunctional role of intrinsic disorder in NF-ÎºB signaling.		2023
37978300	Author Correction: Structure and dynamics of the ASB9 CUL-RING E3 Ligase.		2023
37457835	Dynamic allostery in thrombin-a review.		2023
36940840	Site-specific incorporation of biophysical probes into NF-Ä¸B with non-canonical amino acids.		2023
35151633	Dimer dissociation is a key energetic event in the fold-switch pathway of KaiB.	Biophysical Journal	2022
35638597	Target binding triggers hierarchical phosphorylation of human Argonaute-2 to promote target release.	eLife	2022
35934050	An intrinsically disordered transcription activation domain increases the DNA binding affinity and reduces the specificity of NFÎºB p50/RelA.	Journal of Biological Chemistry	2022
35670666	Allosteric couplings upon binding of RfaH to transcription elongation complexes.	Nucleic Acids Research	2022
34978431	How Thrombomodulin Enables W215A/E217A Thrombin to Cleave Protein C but Not Fibrinogen.	Biochemistry	2022
34714054	Development of a Rapid and Sensitive CasRx-Based Diagnostic Assay for SARS-CoV-2.	ACS Sens	2021
34159782	Hydrogen/Deuterium Exchange and Nuclear Magnetic Resonance Spectroscopy Reveal Dynamic Allostery on Multiple Time Scales in the Serine Protease Thrombin.	Biochemistry	2021
33931701	Serine protease dynamics revealed by NMR analysis of the thrombin-thrombomodulin complex.	Scientific Reports	2021
34088839	Conformation and dynamics of the kinase domain drive subcellular location and activation of LRRK2.	Proc Natl Acad Sci U S A	2021
34029641	Transcription factor NF-ÎºB unravels nucleosomes.	Biochimica et Biophysica Acta - General Subjects	2021
34358463	Open, engage, bind, translocate: The multi-level dynamics of bacterial protein translocation.	Structure	2021
33403747	Sequence and functional differences in the ATPase domains of CHD3 and SNF2H promise potential for selective regulability and drugability.		2021
33268465	The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases.	Molecular and Cellular Proteomics	2021
34742401	Achieving a realistic native protein ensemble byÂ HDX-MS and computational modeling.	Biophysical Journal	2021
34614173	Single-molecule conformational dynamics of a transcription factor reveals a continuum of binding modes controlling association and dissociation.	Nucleic Acids Research	2021
33106816	A Sensitive, Rapid, and Portable CasRx-based Diagnostic Assay for SARS-CoV-2.	medRxiv	2020
31810657	Differential Local Stability Governs the Metamorphic Fold Switch of Bacterial Virulence Factor RfaH.	Biophysical Journal	2020
32487353	Complementarity of Hydrogen/Deuterium Exchange Mass Spectrometry and Cryo-Electron Microscopy.	Trends in Biochemical Sciences	2020
32735805	Intrinsically Disordered Regions of the DNA-Binding Domain of Human FoxP1 Facilitate Domain Swapping.	Journal of Molecular Biology	2020
32513959	Structure and dynamics of the ASB9 CUL-RING E3 Ligase.	Nature Communications	2020
33230150	Surveying biomolecular frustration at atomic resolution.	Nature Communications	2020
31363053	Structural basis for GPCR-independent activation of heterotrimeric Gi proteins.	Proc Natl Acad Sci U S A	2019
31594786	DECA, A Comprehensive, Automatic Post-processing Program for HDX-MS Data.	Molecular and Cellular Proteomics	2019
31641149	Dynamics of ABC Transporter P-glycoprotein in Three Conformational States.	Sci Rep	2019
31659184	Decoupling a tandem-repeat protein: Impact of multiple loop insertions on a modular scaffold.	Scientific Reports	2019
30558884	Accurate Prediction of Amide Exchange in the Fast Limit Reveals Thrombin Allostery.	Biophysical Journal	2019
31033276	Exclusivity and Compensation in NFÎºB Dimer Distributions and IÎºB Inhibition.	Biochemistry	2019
31227607	Cryo-EM structure of OSCA1.2 from <i>Oryza sativa</i> elucidates the mechanical basis of potential membrane hyperosmolality gating.	Proc Natl Acad Sci U S A	2019
29101782	Frustration, function and folding.	Current Opinion in Structural Biology	2018
30076409	RNAs interact with BRD4 to promote enhanced chromatin engagement and transcription activation.	Nature Structural and Molecular Biology	2018
30382093	Calcium sensing by the STIM1 ER-luminal domain.	Nature Communications	2018
30417094	Deciphering and engineering chromodomain-methyllysine peptide recognition.	Sci Adv	2018
30133030	Prediction of the presence of a seventh ankyrin repeat in IÎºBÎµ from homology modeling combined with hydrogen-deuterium exchange mass spectrometry (HDX-MS).	Protein Science	2018
29627358	Hydrogen-deuterium exchange mass spectrometry reveals folding and allostery in protein-protein interactions.	Methods	2018
29625198	RelA-Containing NFÎºB Dimers Have Strikingly Different DNA-Binding Cavities in the Absence of DNA.	Journal of Molecular Biology	2018
29186573	Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2.	Nucleic Acids Research	2018
29420634	Ligand binding modulates the structural dynamics and activity of urokinase-type plasminogen activator: A possible mechanism of plasminogen activation.	PLoS ONE	2018
29634247	Dynamic Consequences of Mutation of Tryptophan 215 in Thrombin.	Biochemistry	2018
28167786	Functional importance of stripping in NFÎºB signaling revealed by a stripping-impaired IÎºBÎ± mutant.	Proceedings of the National Academy of Sciences of the United States of America	2017
28457014	Unusual dimerization of a BcCsp mutant leads to reduced conformational dynamics.		2017
28974687	Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation.	Nature Communications	2017
28611361	Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.	Scientific Reports	2017
29183131	Resolving the NFÎºB Heterodimer Binding Paradox: Strain and Frustration Guide the Binding of Dimeric Transcription Factors.	Journal of the American Chemical Society	2017
29079793	Site-specific identification and quantitation of endogenous SUMO modifications under native conditions.	Nat Commun	2017