Author details

Full Name

Andrew H Coles

Affiliation

ORCID

Career Start Year

2003

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36458209	Mutant huntingtin messenger RNA forms neuronal nuclear clusters in rodent and human brains.	Brain Commun	2022
35795486	PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs.	Mol Ther Nucleic Acids	2022
34935646	Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep.	JCI Insight	2021
34857647	Bis-choline tetrathiomolybdate prevents copper-induced blood-brain barrier damage.	Life Sci Alliance	2021
31375812	A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system.	Nat Biotechnol	2019
30544191	Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo.	Nucleic Acids Res	2019
30535404	Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways.	Nucleic Acids Res	2019
30940496	The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo.	J Control Release	2019
31195240	Serum Deprivation of Mesenchymal Stem Cells Improves Exosome Activity and Alters Lipid and Protein Composition.	iScience	2019
29654062	Efficient Gene Silencing in Brain Tumors with Hydrophobically Modified siRNAs.	Mol Cancer Ther	2018
30451990	RNAi modulation of placental sFLT1 for the treatment of preeclampsia.	Nat Biotechnol	2018
30341012	Exosomes Produced from 3D Cultures of MSCs by Tangential Flow Filtration Show Higher Yield and Improved Activity.	Mol Ther	2018
30143435	Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier.	Mol Ther	2018
30184490	Nuclear Localization of Huntingtin mRNA Is Specific to Cells of Neuronal Origin.	Cell Rep	2018
29432571	Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo.	Nucleic Acids Res	2018
29022758	Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay.	Nucleic Acid Ther	2017
28868334	Loading of Extracellular Vesicles with Chemically Stabilized Hydrophobic siRNAs for the Treatment of Disease in the Central Nervous System.	Bio Protoc	2017
28462988	Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain.	Bioconjug Chem	2017
28591791	5Î¿-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.	Nucleic Acids Res	2017
28966945	A High-throughput Assay for mRNA Silencing in Primary Cortical Neurons <i>in vitro</i> with Oligonucleotide Therapeutics.	Bio Protoc	2017
27504598	Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain.	Mol Ther Nucleic Acids	2016
26595721	A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo.	Nucleic Acid Ther	2016
27506293	Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing.	Mol Ther	2016
26702084	Magnitude of and Prognostic Factors Associated With 1-Year Mortality After Hospital Discharge for Acute Decompensated Heart Failure Based on Ejection Fraction Findings.	Journal of the American Heart Association	2015
26400165	Guanabenz (Wytensinâ¿¢) selectively enhances uptake and efficacy of hydrophobically modified siRNAs.	Nucleic Acids Res	2015
26623938	Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain.	Mol Ther Nucleic Acids	2015
25092194	Long-term survival for patients with acute decompensated heart failure according to ejection fraction findings.	American Journal of Cardiology	2014
24507173	30-year trends in patient characteristics, treatment practices, and long-term outcomes of adults aged 35 to 54Â years hospitalized with acute myocardial infarction.	American Journal of Cardiology	2014
24302573	Hdac6 regulates Tip60-p400 function in stem cells.	Elife	2013
23901296	Survival after hospital discharge for ST-segment elevation and non-ST-segment elevation acute myocardial infarction: a population-based study.	Clinical Epidemiology	2013
22762720	Recent trends in post-discharge mortality among patients with an initial acute myocardial infarction.	American Journal of Cardiology	2012
20145032	Phosphorylation of p53 serine 18 upregulates apoptosis to suppress Myc-induced tumorigenesis.	Molecular Cancer Research	2010
20534538	Inhibitor of growth-4 promotes IkappaB promoter activation to suppress NF-kappaB signaling and innate immunity.	Proceedings of the National Academy of Sciences of the United States of America	2010
18780289	The ING gene family in the regulation of cell growth and tumorigenesis.	Journal of Cellular Physiology	2009
18974112	p37Ing1b regulates B-cell proliferation and cooperates with p53 to suppress diffuse large B-cell lymphomagenesis.	Cancer Research	2008
18070933	Noncanonical Wnt signaling promotes apoptosis in thymocyte development.	Journal of Experimental Medicine	2007
17332334	Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis.	Cancer Research	2007
16810678	Mutation of the SNF2 family member Chd2 affects mouse development and survival.	Journal of Cellular Physiology	2006
14667502	Wnt5a inhibits B cell proliferation and functions as a tumor suppressor in hematopoietic tissue.	Cancer Cell	2003