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Author Details

Haley A Brown
1986
131
54
PMIDPaper TitleJournal TitlePublished Year
37500984BoGH13A<sub>Sus</sub> from Bacteroides ovatus represents a novel α-amylase used for  Bacteroides starch breakdown in the human gut.Cell Mol Life Sci2023
37149527Isothermal Titration Calorimetry for Quantification of Protein-Carbohydrate Interactions.2023
36266970Single-molecule dynamics of surface lipoproteins in bacteroides indicate similarities and cooperativity.Biophysical Journal2022
34780645An ERK5-KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells.Biochem J2021
34180241Structural and Functional Analysis of a Multimodular Hyperthermostable Xylanase-Glucuronoyl Esterase from .Biochemistry2021
33645542Biallelic loss-of-function variants in PLD1 cause congenital right-sided cardiac valve defects and neonatal cardiomyopathy.J Clin Invest2021
34186214Structure and substrate recognition by the Ruminococcus bromii amylosome pullulanases.Journal of Structural Biology2021
32518945Host glycan utilization within the Bacteroidetes Sus-like paradigm.Glycobiology2021
31624005Starch Digestion by Gut Bacteria: Crowdsourcing for Carbs.Trends in Microbiology2020
29076563The structure of glucose-1-phosphate thymidylyltransferase from Mycobacterium tuberculosis reveals the location of an essential magnesium ion in the RmlA-type enzymes.Protein Science2018
30528979Isoform selective PLD inhibition by novel, chiral 2,8-diazaspiro[4.5]decan-1-one derivatives.Bioorganic and Medicinal Chemistry Letters2018
29761597The Mycobacterium tuberculosis complex has a pathway for the biosynthesis of 4-formamido-4,6-dideoxy-d-glucose.Protein Science2018
28209987Targeting phospholipase D in cancer, infection and neurodegenerative disorders.Nat Rev Drug Discov2017
28613820Protein Modification by Endogenously Generated Lipid Electrophiles: Mitochondria as the Source and Target.ACS Chem Biol2017
29023101Biosynthesis of Nucleoside Diphosphoramidates in Campylobacter jejuni.Biochemistry2017
28650156Discovery of a Glutamine Kinase Required for the Biosynthesis of the O-Methyl Phosphoramidate Modifications Found in the Capsular Polysaccharides of Campylobacter jejuni.J Am Chem Soc2017
27256690Quantitative profiling of the endonuclear glycerophospholipidome of murine embryonic fibroblasts.Journal of Lipid Research2016
27044099Lenz-Majewski mutations in PTDSS1 affect phosphatidylinositol 4-phosphate metabolism at ER-PM and ER-Golgi junctions.Proceedings of the National Academy of Sciences of the United States of America2016
26020637Phospholipase D1 Couples CD4+ T Cell Activation to c-Myc-Dependent Deoxyribonucleotide Pool Expansion and HIV-1 Replication.PLoS Pathogens2015
25286402Development of an improved mammalian overexpression method for human CD62L.Protein Expression and Purification2015
25646564Human phospholipase D activity transiently regulates pyrimidine biosynthesis in malignant gliomas.ACS Chemical Biology2015
25565226Biochemical characterization of a Pseudomonas aeruginosa phospholipase D.Biochemistry2015
25600868The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance.Cell Reports2015
25384256Discovery of desketoraloxifene analogues as inhibitors of mammalian, Pseudomonas aeruginosa, and NAPE phospholipase D enzymes.ACS Chem Biol2015
25598080Biomarkers of NAFLD progression: a lipidomics approach to an epidemic.J Lipid Res2015
26392530Competition and allostery govern substrate selectivity of cyclooxygenase-2.Proceedings of the National Academy of Sciences of the United States of America2015
26174084Biochemical studies on WbcA, a sugar epimerase from Yersinia enterocolitica.Protein Science2015
26448476Lipid composition of viral envelope of three strains of influenza virus - not all viruses are created equal.ACS Infect Dis2015
25065577Phospholipase D facilitates efficient entry of influenza virus, allowing escape from innate immune inhibition.J Biol Chem2014
25466173Further evaluation of novel structural modifications to scaffolds that engender PLD isoform selective inhibition.Bioorganic and Medicinal Chemistry Letters2014
23912460Hyperactivation of EGFR and downstream effector phospholipase D1 by oncogenic FAM83B.Oncogene2014
24403601A phosphatidylinositol transfer protein integrates phosphoinositide signaling with lipid droplet metabolism to regulate a developmental program of nutrient stress-induced membrane biogenesis.Mol Biol Cell2014
24257753Phospholipase D2 mediates survival signaling through direct regulation of Akt in glioblastoma cells.Journal of Biological Chemistry2014
24440821Chemical modulation of glycerolipid signaling and metabolic pathways.2014
25244928Phospholipase D signaling pathways and phosphatidic acid as therapeutic targets in cancer.Pharmacological Reviews2014
24859739Enhanced synthesis of saturated phospholipids is associated with ER stress and lipotoxicity in palmitate treated hepatic cells.Journal of Lipid Research2014
24945818Peroxisomes are required for lipid metabolism and muscle function in Drosophila melanogaster.PLoS One2014
25210004Discovery of a highly selective PLD2 inhibitor (ML395): a new probe with improved physiochemical properties and broad-spectrum antiviral activity against influenza strains.ChemMedChem2014
23723068Regulation of phospholipase D activity and phosphatidic acid production after purinergic (P2Y6) receptor stimulation.Journal of Biological Chemistry2013
23776196Analysis of inflammatory and lipid metabolic networks across RAW264.7 and thioglycolate-elicited macrophages.J Lipid Res2013
2418906925-Hydroxycholesterol activates the integrated stress response to reprogram transcription and translation in macrophages.J Biol Chem2013
24095738The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome.Cell Rep2013
23785301Multi-organ abnormalities and mTORC1 activation in zebrafish model of multiple acyl-CoA dehydrogenase deficiency.PLoS Genetics2013
24090246Diacylglycerol kinase delta promotes lipogenesis.Biochemistry2013
23445448Development of dual PLD1/2 and PLD2 selective inhibitors from a common 1,3,8-Triazaspiro[4.5]decane Core: discovery of Ml298 and Ml299 that decrease invasive migration in U87-MG glioblastoma cells.J Med Chem2013
23442130Sum of the parts: mass spectrometry-based metabolomics.Biochemistry2013
23684610Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116.Cell Reports2013
23307946Cobalt carbonyl complexes as probes for alkyne-tagged lipids.Journal of Lipid Research2013
23178537Long term myriocin treatment increases MRP1 transport activity.International Journal of Biochemistry and Cell Biology2013
23414292Bifunctional electrophiles cross-link thioredoxins with redox relay partners in cells.Chemical Research in Toxicology2013
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IBM Corporation
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Duke University Medical Center
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