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Author Details

Michael-Christopher Keogh
EpiCypher Inc.
1997
54
28
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36865140Structural basis of histone H2A lysine 119 deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1.bioRxiv2023
37863054SRCAP mutations drive clonal hematopoiesis through epigenetic and DNA repair dysregulation.Cell Stem Cell2023
37546815Multivalent binding of the tardigrade Dsup protein to chromatin promotes yeast survival and longevity upon exposure to oxidative damage.Res Sq2023
37204295An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability.Elife2023
34782742A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization.Nat Chem Biol2022
36458689<i>Drosophila</i> SUMM4 complex couples insulator function and DNA replication control.Elife2022
34958661Arf6 anchors Cdr2 nodes at the cell cortex to control cell size at division.J Cell Biol2022
35103971The dCypher Approach to Interrogate Chromatin Reader Activity Against Posttranslational Modification-Defined Histone Peptides and Nucleosomes.Methods Mol Biol2022
31373129Dysregulation of the histone demethylase KDM6B in alcohol dependence is associated with epigenetic regulation of inflammatory signaling pathways.Addict Biol2021
33589837Decoding the protein composition of whole nucleosomes with Nuc-MS.Nat Methods2021
33749242Separation and Characterization of Endogenous Nucleosomes by Native Capillary Zone Electrophoresis-Top-Down Mass Spectrometry.Anal Chem2021
33657400Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis.Mol Cell2021
34819353A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer.Genes Dev2021
34426512A ChIP-exo screen of 887 Protein Capture Reagents Program transcription factor antibodies in human cells.Genome Res2021
33986537Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands.Nat Genet2021
33420999Chromatin Immunoprecipitation (ChIP) to Study DNA-Protein Interactions.Methods Mol Biol2021
32442403SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy.Cancer Cell2020
31980037Characterization of the plant homeodomain (PHD) reader family for their histone tail interactions.Epigenetics Chromatin2020
32654410Quantification of citrullinated histones: Development of an improved assay to reliably quantify nucleosomal H3Cit in human plasma.J Thromb Haemost2020
31485078The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape.Nature2019
30244833Examining the Roles of H3K4 Methylation States with Systematically Characterized Antibodies.Mol Cell2018
24565511Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function.Cell Rep2014
25228646Drosophila TAP/p32 is a core histone chaperone that cooperates with NAP-1, NLP, and nucleophosmin in sperm chromatin remodeling during fertilization.Genes Dev2014
25302077Evolutionarily conserved genetic interactions with budding and fission yeast MutS identify orthologous relationships in mismatch repair-deficient cancer cells.Genome Med2014
23457193The carboxyl terminus of Rtt109 functions in chaperone control of histone acetylation.Eukaryot Cell2013
22128187The replication-independent histone H3-H4 chaperones HIR, ASF1, and RTT106 co-operate to maintain promoter fidelity.J Biol Chem2012
22761995Poly-acetylated chromatin signatures are preferred epitopes for site-specific histone H4 acetyl antibodies.Sci Rep2012
22681890Hierarchical modularity and the evolution of genetic interactomes across species.Mol Cell2012
20092611Sometimes one just isn't enough: do vertebrates contain an H2A.Z hyper-variant?J Biol2010
21127252Rewiring of genetic networks in response to DNA damage.Science2010
20952395Individual lysine acetylations on the N terminus of Saccharomyces cerevisiae H2A.Z are highly but not differentially regulated.J Biol Chem2010
19269370Functional organization of the S. cerevisiae phosphorylation network.Cell2009
19915592An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe.Nat Struct Mol Biol2009
19131970Ctk1 promotes dissociation of basal transcription factors from elongating RNA polymerase II.EMBO J2009
18458063Chaperone control of the activity and specificity of the histone H3 acetyltransferase Rtt109.Mol Cell Biol2008
16299494A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery.Nature2006
16936829GammaH2AX and its role in DNA double-strand break repair.Biochem Cell Biol2006
16543219The Saccharomyces cerevisiae histone H2A variant Htz1 is acetylated by NuA4.Genes Dev2006
15886201BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II.J Biol Chem2005
16286008Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.Cell2005
16310392gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair.Mol Cell2005
14769992Using chromatin immunoprecipitation to map cotranscriptional mRNA processing in Saccharomyces cerevisiae.Methods Mol Biol2004
15610744Proteasome involvement in the repair of DNA double-strand breaks.Mol Cell2004
15353583Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4.Proc Natl Acad Sci U S A2004
14690608A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1.Mol Cell2003
12972617Bur1 kinase is required for efficient transcription elongation by RNA polymerase II.Mol Cell Biol2003
11839796Kin28 is found within TFIIH and a Kin28-Ccl1-Tfb3 trimer complex with differential sensitivities to T-loop phosphorylation.Mol Cell Biol2002
12455993Divergent subunit interactions among fungal mRNA 5'-capping machineries.Eukaryot Cell2002
10594013Kin28, the TFIIH-associated carboxy-terminal domain kinase, facilitates the recruitment of mRNA processing machinery to RNA polymerase II.Mol Cell Biol2000
10476221Design of a muscle cell-specific expression vector utilising human vascular smooth muscle alpha-actin regulatory elements.Gene Ther1999
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Collaborators

Nevan J Krogan (CM4AI)
University of California San Francisco
Co-authored papers 15
Stephen Buratowski
Harvard Medical School
Co-authored papers 13
Jack F Greenblatt
College Street, University of Toronto
Co-authored papers 11
Hyun-Soo Kim
Wonju Severance Christian Hospital
Co-authored papers 8
Jeffrey Fillingham
Toronto Metropolitan University
Co-authored papers 8
Andrew Emili
Boston University School of Medicine, Boston University
Co-authored papers 7
Monika Mehta
Albert Einstein College of Medicine
Co-authored papers 5
Michael Shales
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 5
Brian D Strahl
University of North Carolina
Co-authored papers 5
Andrea C Silva
Albert Einstein College of Medicine
Co-authored papers 4
Nira Datta
Co-authored papers 4
Vladimir Podolny
Harvard Medical School
Co-authored papers 4
Assen Roguev
University of California, USA Quantitative Biosciences Institute (QBI) san francisco
Co-authored papers 4
Scott B Rothbart
Van Andel Institute
Co-authored papers 4
Sean R Collins
University of California davis
Co-authored papers 3
Colm J Ryan
University College Dublin
Co-authored papers 3
Chika Sawa
Showa University School of Medicine
Co-authored papers 3
Gerard Cagney
Conway Institute of Biomedical and Biomolecular Sciences, University College Dublin
Co-authored papers 3
Winfried Edelmann
Albert Einstein College of Medicine
Co-authored papers 3
Zu-Wen Sun
EpiCypher Inc.
Co-authored papers 3
Ali Shilatifard
Northwestern University Feinberg School of Medicine
Co-authored papers 3
Thomas Kislinger
Princess Margaret Cancer Centre, University Health Network, University of Toronto
Co-authored papers 3
Kevan M Shokat
University of California San Francisco
Co-authored papers 3
C David Allis
The Rockefeller University
Co-authored papers 3
Timothy R Hughes
University of Toronto
Co-authored papers 3
Thomas A Mennella
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Co-authored papers 2
Hannes Braberg
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