Author details

Full Name

Ron Firestein

Affiliation

ORCID

Career Start Year

1996

Papers

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
37001527	Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities.	Cancer Cell	2023
36335802	The children's brain tumor network (CBTN) - Accelerating research in pediatric central nervous system tumors through collaboration and open science.	Neoplasia	2023
37656627	A protocol to establish cell line models from rare pediatric solid tumors.		2023
37145169	ONC201 in combination with paxalisib for the treatment of H3K27-altered diffuse midline glioma.	Cancer Res	2023
37195023	ONC201 in Combination with Paxalisib for the Treatment of H3K27-Altered Diffuse Midline Glioma.	Cancer Res	2023
34910943	MED12 and BRD4 cooperate to sustain cancer growth upon loss of mediator kinase.	Molecular Cell	2022
36006697	CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF.	Journal of Clinical Investigation	2022
36206404	Development of T-cell engagers selective for cells co-expressing two antigens.	mAbs	2022
34680294	Atypical Teratoid Rhabdoid Tumours Are Susceptible to Panobinostat-Mediated Differentiation Therapy.	Cancers (Basel)	2021
34138730	Genome-scale CRISPR-Cas9 screen of Wnt/Î²-catenin signaling identifies therapeutic targets for colorectal cancer.	Science advances	2021
34522092	Pharmacodynamic Studies of Fluorescent Diamond Carriers of Doxorubicin in Liver Cancer Cells and Colorectal Cancer Organoids.	Nanotechnology, Science and Applications	2021
32961708	Transcriptional Regulation of Wnt/Î²-Catenin Pathway in Colorectal Cancer.	Cells	2020
31676543	Correction: An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer.	Molecular Cancer Therapeutics	2019
30693281	Molecular and Functions of the CDK8 and CDK19 Kinase Modules.	Frontiers in Cell and Developmental Biology	2018
30043751	Pan-Cancer Metabolic Signature Predicts Co-Dependency on Glutaminase and De Novo Glutathione Synthesis Linked to a High-Mesenchymal Cell State.	Cell Metab	2018
29549256	PLK1 has tumor-suppressive potential in APC-truncated colon cancer cells.	Nat Commun	2018
29282299	An Anti-GDNF Family Receptor Alpha 1 (GFRA1) Antibody-Drug Conjugate for the Treatment of Hormone Receptor-Positive Breast Cancer.	Molecular Cancer Therapeutics	2018
27760836	Preclinical Efficacy of an Antibody-Drug Conjugate Targeting Mesothelin Correlates with Quantitative 89Zr-ImmunoPET.	Molecular Cancer Therapeutics	2017
28361078	Targeting the seeds of small cell lung cancer.	Annals of Translational Medicine (discontinued)	2017
27793850	Phase I study of safety and pharmacokinetics of the anti-MUC16 antibody-drug conjugate DMUC5754A in patients with platinum-resistant ovarian cancer or unresectable pancreatic cancer.	Annals of Oncology	2016
26752646	CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer.	Journal of Clinical Investigation	2016
27326333	Design and Development of a Series of Potent and Selective Type II Inhibitors of CDK8.	ACS Medicinal Chemistry Letters	2016
26985305	Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells.	ACS Medicinal Chemistry Letters	2016
27479743	Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.	Nat Chem Biol	2016
27029064	ImmunoPET helps predicting the efficacy of antibody-drug conjugates targeting TENB2 and STEAP1.	Oncotarget	2016
26700806	Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function.	Nature	2016
26235356	Cdk8 deletion in the Apc(Min) murine tumour model represses EZH2 activity and accelerates tumourigenesis.	Journal of Pathology	2015
25838397	Upregulation of Periostin and Reactive Stroma Is Associated with Primary Chemoresistance and Predicts Clinical Outcomes in Epithelial Ovarian Cancer.	Clin Cancer Res	2015
25862760	An Antibody-Drug Conjugate Directed against Lymphocyte Antigen 6 Complex, Locus E (LY6E) Provides Robust Tumor Killing in a Wide Range of Solid Tumor Malignancies.	Clinical Cancer Research	2015
25645927	HSP105 recruits protein phosphatase 2A to dephosphorylate Î²-catenin.	Mol Cell Biol	2015
25853436	An anti-B7-H4 antibody-drug conjugate for the treatment of breast cancer.	Molecular Pharmaceutics	2015
25937372	Castration-resistant Lgr5(+) cells are long-lived stem cells required for prostatic regeneration.	Stem Cell Reports	2015
26582901	Targeting LGR5+ cells with an antibody-drug conjugate for the treatment of colon cancer.	Science Translational Medicine	2015
26156394	Preclinical Development of an Anti-NaPi2b (SLC34A2) Antibody-Drug Conjugate as a Therapeutic for Non-Small Cell Lung and Ovarian Cancers.	Clinical Cancer Research	2015
24788092	An integrative analysis of colon cancer identifies an essential function for PRPF6 in tumor growth.	Genes and Development	2014
25249555	An antimesothelin-monomethyl auristatin e conjugate with potent antitumor activity in ovarian, pancreatic, and mesothelioma models.	Molecular Cancer Therapeutics	2014
24807215	Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.	Nat Commun	2014
23539443	A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.	Cancer Research	2013
22889168	An integrated approach to identify normal tissue expression of targets for antibody-drug conjugates: case study of TENB2.	British Journal of Pharmacology	2013
23680147	Oncogenic ERBB3 mutations in human cancers.	Cancer Cell	2013
23224736	Lactate dehydrogenase B is required for the growth of KRAS-dependent lung adenocarcinomas.	Clinical Cancer Research	2013
23139210	An integrated genomic screen identifies LDHB as an essential gene for triple-negative breast cancer.	Cancer Res	2012
22345154	CDK8 maintains tumor dedifferentiation and embryonic stem cell pluripotency.	Cancer Research	2012
22613716	The melanosomal protein PMEL17 as a target for antibody drug conjugate therapy in melanoma.	Journal of Biological Chemistry	2012
21245091	An antibody-drug conjugate targeting the endothelin B receptor for the treatment of melanoma.	Clinical Cancer Research	2011
20126544	CK1epsilon is required for breast cancers dependent on beta-catenin activity.	PLoS One	2010
19790197	CDK8 expression in 470 colorectal cancers in relation to beta-catenin activation, other molecular alterations and patient survival.	Int J Cancer	2010
19808961	Revving the Throttle on an oncogene: CDK8 takes the driver seat.	Cancer Res	2009
19364473	Integrative genomic approaches to understanding cancer.	Biochim Biophys Acta	2009
19430421	SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.	Mod Pathol	2009