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Author Details

Gerry Weinmaster
David Geffen School of Medicine, University of California-Los Angeles
1975
88
58
PMIDPaper TitleJournal TitlePublished Year
25535917Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells.Dev Cell2014
22306180Notch ligand endocytosis: mechanistic basis of signaling activity.Semin Cell Dev Biol2012
22658936Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin.Dev Cell2012
22658935Optical tweezers studies on Notch: single-molecule interaction strength is independent of ligand endocytosis.Dev Cell2012
21763614Notch ligand ubiquitylation: what is it good for?Dev Cell2011
19839776Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells.J Bone Miner Res2010
21062863Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome.Development2010
20816393Canonical and non-canonical Notch ligands.Curr Top Dev Biol2010
19567869Numb regulates post-endocytic trafficking and degradation of Notch1.J Biol Chem2009
19704010Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling.Mol Cell Biol2009
18758484The many facets of Notch ligands.Oncogene2008
17296795DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur.J Cell Biol2007
17547700Notch signaling--constantly on the move.Traffic2007
16492672Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation.J Biol Chem2006
16908627A garden of Notch-ly delights.Development2006
15788413The extracellular matrix protein MAGP-2 interacts with Jagged1 and induces its shedding from the cell surface.J Biol Chem2005
16144902The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands.J Cell Biol2005
16107360Functional analysis of a recurrent missense mutation in Notch3 in CADASIL.J Neurol Neurosurg Psychiatry2005
15574878Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1.Mol Biol Cell2005
12853432Sequential signaling through Notch1 and erbB receptors mediates radial glia differentiation.J Neurosci2003
12966214Extrinsic and intrinsic factors governing cell fate in cortical progenitor cultures.Dev Neurosci2003
14570574Modulation of notch signaling during somitogenesis.Annu Rev Cell Dev Biol2003
12700242Basal expression of IkappaBalpha is controlled by the mammalian transcriptional repressor RBP-J (CBF1) and its activator Notch1.J Biol Chem2003
12629177Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells.J Neurosci2003
11900468Developmental changes in Notch1 and numb expression mediated by local cell-cell interactions underlie progressively increasing delta sensitivity in neural crest stem cells.Dev Biol2002
12205678Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation.J Neurosci Res2002
12397111Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon.Development2002
12111827A secreted Delta1-Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling.J Neurosci Res2002
11909813CADASIL Notch3 mutant proteins localize to the cell surface and bind ligand.Circ Res2002
11150244Ligand-induced signaling in the absence of furin processing of Notch1.Dev Biol2001
11359897The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA.Mol Cell Biol2001
11222720Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC.J Virol2001
11342604Distinct mechanisms contribute to generate and change the CD4:CD8 cell ratio during thymus development: a role for the Notch ligand, Jagged1.J Immunol2001
11713346The notch receptor and its ligands are selectively expressed during hematopoietic development in the mouse.Stem Cells2001
11578869Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.Mech Dev2001
11739589Transcription factor expression and Notch-dependent regulation of neural progenitors in the adult rat spinal cord.J Neurosci2001
11564735Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor.J Biol Chem2001
11438922Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development.J Comp Neurol2001
11171333Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation.Development2001
10607392Nuclear Notch1 signaling and the regulation of dendritic development.Nat Neurosci2000
10964583Notch4 and Jagged-1 induce microvessel differentiation of rat brain endothelial cells.Microvasc Res2000
10868931Independent development of pancreatic alpha- and beta-cells from neurogenin3-expressing precursors: a role for the notch pathway in repression of premature differentiation.Diabetes2000
10899933Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.J Neurochem2000
10850492Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells.Cell2000
10934472Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.Nat Cell Biol2000
10889061Notch signal transduction: a real rip and more.Curr Opin Genet Dev2000
11035081Notch signaling enhances survival and alters differentiation of 32D myeloblasts.J Immunol2000
11193154Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity.Ann N Y Acad Sci2000
10713164SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function.Mol Cell Biol2000
10534349Hepatic jagged1 expression studies.Hepatology1999
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Collaborators

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Salk Institute for Biological Studies
Co-authored papers 7
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University of California los angeles
Co-authored papers 6
Columbia University
Co-authored papers 6
Pepperdine University
Co-authored papers 5
Johns Hopkins University School of Medicine
Co-authored papers 5
Washington University
Co-authored papers 4
University of California, University of California Irvine
Co-authored papers 4
Novartis Pharma AG
Co-authored papers 4
Massachusetts General Hospital
Co-authored papers 2
Salk Institute for Biological Studies
Co-authored papers 2
Co-authored papers 2
Co-authored papers 1
Co-authored papers 1
The University of Tokyo.
Co-authored papers 1
Co-authored papers 1
University of Fukui
Co-authored papers 1
Co-authored papers 1
American Association for Cancer Research, Henry Ford Hospital, Ludwig Institute for Cancer Research, National Cancer Institute, Salk Institute for Biological Studies, University of Cambridge, University of Texas MD Anderson Cancer Center, Virginia Commonwealth University
Co-authored papers 1
Co-authored papers 1
German Center for Diabetes Research (DZD e.V.)
Co-authored papers 1
university of california los angeles
Co-authored papers 1
UCSF Medical School
Co-authored papers 1
Massachusetts General Hospital, Harvard Medical School
Co-authored papers 1