Author details

Full Name

John R Griffiths

Affiliation

ORCID

Career Start Year

1972

Papers

314

H Index

Expertise

CM4AI Collaborator

PMID	Paper Title	Journal Title	Published Year
36429023	Survival Pathways of HIF-Deficient Tumour Cells: TCA Inhibition, Peroxisomal Fatty Acid Oxidation Activation and an AMPK-PGC-1Î± Hypoxia Sensor.	Cells	2022
34572020	HIF-1-Independent Mechanisms Regulating Metabolic Adaptation in Hypoxic Cancer Cells.	Cells	2021
34260948	Beyond factor H: The impact of genetic-risk variants for age-related macular degeneration on circulating factor-H-like 1 and factor-H-related protein concentrations.	Am J Hum Genet	2021
32788746	Apc tumours and normal mouse small intestines show linear metabolite concentration and DNA cytosine hydroxymethylation gradients from pylorus to colon.	Scientific Reports	2020
32437164	Intravitreal Pharmacokinetic Study of the Antiangiogenic Glycoprotein Opticin.	Molecular Pharmaceutics	2020
30980319	A Combined Chemical Derivatization/Mass Spectrometric Method for theÂ Enhanced Detection and Relative Quantification of Protein Ubiquitination.	Methods in Molecular Biology	2019
29794225	Depicting Changes in Tumor Biology in Response to Cetuximab Monotherapy or Combination Therapy by Apoptosis and Proliferation Imaging Using F-ICMT-11 and F-FLT PET.		2018
28971330	3'-Deoxy-3'-[F]Fluorothymidine Uptake Is Related to Thymidine Phosphorylase Expression in Various Experimental Tumor Models.	Molecular Imaging and Biology	2018
30206370	Carbonic anhydrase IX is a pH-stat that sets an acidic tumour extracellular pH in vivo.	Br J Cancer	2018
29476002	Thymidine Metabolism as a Confounding Factor for 3'-Deoxy-3'-F-Fluorothymidine Uptake After Therapy in a Colorectal Cancer Model.		2018
28261475	The action of Î²-hydroxybutyrate on the growth, metabolism and global histone H3 acetylation of spontaneous mouse mammary tumours: evidence of a Î²-hydroxybutyrate paradox.		2017
29247446	Correction to: The relationship between endogenous thymidine concentrations and [F]FLT uptake in a range of preclinical tumour models.	EJNMMI Research	2017
29069586	Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects.	Cell Reports	2017
29069098	Exploration of human brain tumour metabolism using pairwise metabolite-metabolite correlation analysis (MMCA) of HR-MAS 1H NMR spectra.	PLoS ONE	2017
27279574	Quantitative and textural analysis of magnetization transfer and diffusion images in the early detection of brain metastases.	Magnetic Resonance in Medicine	2017
27798786	Response Monitoring with [F]FLT PET and Diffusion-Weighted MRI After Cytotoxic 5-FU Treatment in an Experimental Rat Model for Colorectal Liver Metastases.	Molecular Imaging and Biology	2017
27798751	Assessment of early treatment response to neoadjuvant chemotherapy in breast cancer using non-mono-exponential diffusion models: a feasibility study comparing the baseline and mid-treatment MRI examinations.	Eur Radiol	2017
27725679	Imaging biomarker roadmap for cancer studies.	Nat Rev Clin Oncol	2017
27784748	Gemcitabine Mechanism of Action Confounds Early Assessment of Treatment Response by 3'-Deoxy-3'-[18F]Fluorothymidine in Preclinical Models of Lung Cancer.	Cancer Research	2016
27429605	Response of Degarelix treatment in human prostate cancer monitored by HR-MAS [1]H NMR spectroscopy.	Metabolomics	2016
26915795	Classification of brain tumours from MR spectra: the INTERPRET collaboration and its outcomes.	NMR in Biomedicine	2016
26140696	Multimodal MRI can identify perfusion and metabolic changes in the invasive margin of glioblastomas.	Journal of Magnetic Resonance Imaging	2016
25995019	Multi-institutional validation of a novel textural analysis tool for preoperative stratification of suspected thyroid tumors on diffusion-weighted MRI.	Magn Reson Med	2016
26579563	Effect of Radiofrequency Transmit Field Correction on Quantitative Dynamic Contrast-enhanced MR Imaging of the Breast at 3.0 T.	Radiology	2016
27798602	S-2-hydroxyglutarate regulates CD8 T-lymphocyte fate.	Nature	2016
27515446	The relationship between endogenous thymidine concentrations and [(18)F]FLT uptake in a range of preclinical tumour models.	EJNMMI Research	2016
24737647	The application of targeted mass spectrometry-based strategies to the detection and localization of post-translational modifications.	Mass Spectrometry Reviews	2015
25487150	A PP1-PP2A phosphatase relay controls mitotic progression.	Nature	2015
26012876	Apparent diffusion coefficient is highly reproducible on preclinical imaging systems: Evidence from a seven-center multivendor study.	Journal of Magnetic Resonance Imaging	2015
26657335	Choline Kinase Alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target.	J Natl Cancer Inst	2015
26560143	Absolute Quantification of Endogenous Ras Isoform Abundance.	PLoS ONE	2015
26491426	Metabolomic changes during cellular transformation monitored by metabolite-metabolite correlation analysis and correlated with gene expression.	Metabolomics	2015
24777288	Variability of Proliferation and Diffusion in Different Lung Cancer Models as Measured by 3'-Deoxy-3'-Â¹â¸F-Fluorothymidine PET and Diffusion-Weighted MR Imaging.		2014
24549895	Mass spectral enhanced detection of Ubls using SWATH acquisition: MEDUSA--simultaneous quantification of SUMO and ubiquitin-derived isopeptides.	Journal of the American Society for Mass Spectrometry	2014
24892448	Dichloroacetate induces autophagy in colorectal cancer cells and tumours.	British Journal of Cancer	2014
24836440	BCR-ABL affects STAT5A and STAT5B differentially.	PLoS ONE	2014
24874484	Gemcitabine diphosphate choline is a major metabolite linked to the Kennedy pathway in pancreatic cancer models in vivo.	Br J Cancer	2014
23381851	Application of the MIDAS approach for analysis of lysine acetylation sites.	Methods in Molecular Biology	2013
23943332	Chemically facilitating the generation of diagnostic ions from SUMO(2/3) remnant isopeptides.	Rapid Communications in Mass Spectrometry	2013
23813534	Muscle metabolism and activation heterogeneity by combined 31P chemical shift and T2 imaging, and pulmonary O2 uptake during incremental knee-extensor exercise.	Journal of Applied Physiology	2013
23849692	Evaluation and immunohistochemical qualification of carbogen-induced Î¿R2 as a noninvasive imaging biomarker of improved tumor oxygenation.	Int J Radiat Oncol Biol Phys	2013
23931426	Noninvasive phosphorus magnetic resonance spectroscopic imaging predicts outcome to first-line chemotherapy in newly diagnosed patients with diffuse large B-cell lymphoma.	Acad Radiol	2013
23926047	Drosophila F-BAR protein Syndapin contributes to coupling the plasma membrane and contractile ring in cytokinesis.	Open Biology	2013
23361369	Enhanced detection of ubiquitin isopeptides using reductive methylation.	Journal of the American Society for Mass Spectrometry	2013
23239325	A novel approach to the analysis of SUMOylation with the independent use of trypsin and elastase digestion followed by database searching utilising consecutive residue addition to lysine.	Rapid Communications in Mass Spectrometry	2013
23277191	Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome.	Journal of Molecular and Cellular Cardiology	2013
22194463	Histone deacetylase inhibition increases levels of choline kinase Î± and phosphocholine facilitating noninvasive imaging in human cancers.	Cancer Res	2012
22401303	Magnetic resonance spectroscopy of cancer metabolism and response to therapy.	Radiation Research	2012
22535478	Repeatability of edited lactate and other metabolites in astrocytoma at 3T.	Journal of Magnetic Resonance Imaging	2012
22332064	Advanced ovarian cancer: multiparametric MR imaging demonstrates response- and metastasis-specific effects.	Radiology	2012