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Author Details

Mehrdad Shamloo
Stanford University School of Medicine
1994
73
41
Nevan J Krogan (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37090796The anti-inflammatory effects of photobiomodulation are mediated by cytokines: Evidence from a mouse model of inflammation.Front Neurosci2023
37495851Locus Coeruleus and Noradrenergic Pharmacology in Neurodegenerative Disease.Handb Exp Pharmacol2023
38036718Beta-2 adrenergic receptor agonism alters astrocyte phagocytic activity and has potential applications to psychiatric disease.Discov Ment Health2023
36224417Maturation and circuit integration of transplanted human cortical organoids.Nature2022
35634307Upregulating Human Cathelicidin Antimicrobial Peptide LL-37 Expression May Prevent Severe COVID-19 Inflammatory Responses and Reduce Microthrombosis.Front Immunol2022
36532725Selective Vulnerability of the Locus Coeruleus Noradrenergic System and its Role in Modulation of Neuroinflammation, Cognition, and Neurodegeneration.Front Pharmacol2022
34320462Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice.Neurobiol Aging2021
33854131Enantiomers of 2-methylglutamate and 2-methylglutamine selectively impact mouse brain metabolism and behavior.Sci Rep2021
34880498Exercise plasma boosts memory and dampens brain inflammation via clusterin.Nature2021
34273193Enantiomers of 4-aminopentanoic acid act as false GABAergic neurotransmitters and impact mouse behavior.J Neurochem2021
29670176Activity-dependent modulation of hippocampal synaptic plasticity via PirB and endocannabinoids.Mol Psychiatry2019
31263278Peripheral TREM1 responses to brain and intestinal immunogens amplify stroke severity.Nat Immunol2019
30927072LRRK2 modifies α-syn pathology and spread in mouse models and human neurons.Acta Neuropathol2019
31036664PGE<sub>2</sub> signaling via the neuronal EP2 receptor increases injury in a model of cerebral ischemia.Proc Natl Acad Sci U S A2019
29335339Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis.EMBO Mol Med2018
30232469Interaction of mitochondrial fission factor with dynamin related protein 1 governs physiological mitochondrial function in vivo.Sci Rep2018
30486515Intracerebral Delivery of Brain-Derived Neurotrophic Factor Using HyStem<sup>®</sup>-C Hydrogel Implants Improves Functional Recovery and Reduces Neuroinflammation in a Rat Model of Ischemic Stroke.Int J Mol Sci2018
30275311Early adolescent Rai1 reactivation reverses transcriptional and social interaction deficits in a mouse model of Smith-Magenis syndrome.Proc Natl Acad Sci U S A2018
27926996Small molecule modulator of sigma 2 receptor is neuroprotective and reduces cognitive deficits and neuroinflammation in experimental models of Alzheimer's disease.J Neurochem2017
28089846Modulation of neuroinflammation and pathology in the 5XFAD mouse model of Alzheimer's disease using a biased and selective beta-1 adrenergic receptor partial agonist.Neuropharmacology2017
29464060Drp1/Fis1 interaction mediates mitochondrial dysfunction, bioenergetic failure and cognitive decline in Alzheimer's disease.Oncotarget2017
29124108An 8-week, open-label, dose-finding study of nimodipine for the treatment of progranulin insufficiency from <i>GRN</i> gene mutations.Alzheimers Dement (N Y)2017
28746336Discovery of novel brain permeable and G protein-biased beta-1 adrenergic receptor partial agonists for the treatment of neurocognitive disorders.PLoS One2017
28721361Role of Endoplasmic Reticulum Stress in Learning and Memory Impairment and Alzheimer's Disease-Like Neuropathology in the PS19 and APP<sup>Swe</sup> Mouse Models of Tauopathy and Amyloidosis.eNeuro2017
27521836Novel, selective EPO receptor ligands lacking erythropoietic activity reduce infarct size in acute myocardial infarction in rats.Pharmacol Res2016
28171570A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.Hum Mol Genet2016
27821553Potential biomarkers to follow the progression and treatment response of Huntington's disease.J Exp Med2016
27693255Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome.Neuron2016
26390242Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits.Nat Med2015
24883337β1-adrenergic receptor activation enhances memory in Alzheimer's disease model.Ann Clin Transl Neurol2014
25390368Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers I: Abeta 42 oligomer binding to specific neuronal receptors is displaced by drug candidates that improve cognitive deficits.PLoS One2014
24806669A death receptor 6-amyloid precursor protein pathway regulates synapse density in the mature CNS but does not contribute to Alzheimer's disease-related pathophysiology in murine models.J Neurosci2014
24794428Behavioral abnormalities and circuit defects in the basal ganglia of a mouse model of 16p11.2 deletion syndrome.Cell Rep2014
24898660Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP(L/S) transgenic mice.J Alzheimers Dis2014
23340518GluN2B antagonism affects interneurons and leads to immediate and persistent changes in synaptic plasticity, oscillations, and behavior.Neuropsychopharmacology2013
24285878A small molecule TrkB ligand reduces motor impairment and neuropathology in R6/2 and BACHD mouse models of Huntington's disease.J Neurosci2013
24231356Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.J Clin Invest2013
23874920A pharmacological screening approach for discovery of neuroprotective compounds in ischemic stroke.PLoS One2013
23946404A dramatic increase of C1q protein in the CNS during normal aging.J Neurosci2013
22574282Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function.Brain Behav2012
23222102FoxO6 regulates memory consolidation and synaptic function.Genes Dev2012
23029555Npas4: a neuronal transcription factor with a key role in social and cognitive functions relevant to developmental disorders.PLoS One2012
23139913Stratification substantially reduces behavioral variability in the hypoxic-ischemic stroke model.Brain Behav2012
22764230Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists.J Neurosci2012
21278085The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke.Brain2011
22057346Identification of a central role for complement in osteoarthritis.Nat Med2011
21808020Autism-linked neuroligin-3 R451C mutation differentially alters hippocampal and cortical synaptic function.Proc Natl Acad Sci U S A2011
21878566Mouse model of Timothy syndrome recapitulates triad of autistic traits.Proc Natl Acad Sci U S A2011
21527343Comprehensive behavioral phenotyping of Ts65Dn mouse model of Down syndrome: activation of β1-adrenergic receptor by xamoterol as a potential cognitive enhancer.Neurobiol Dis2011
21732485Transplanted stem cell-secreted vascular endothelial growth factor effects poststroke recovery, inflammation, and vascular repair.Stem Cells2011
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Collaborators

Stanford University
Co-authored papers 6
Stanford University
Co-authored papers 4
University of California San Diego
Co-authored papers 3
Gladstone Institutes
Co-authored papers 2
Gladstone Institutes
Co-authored papers 2
New York University Grossman School of Medicine
Co-authored papers 2
Stanford University
Co-authored papers 2
Helen and Robert Appel Alzheimer's Disease Research Institute
Co-authored papers 2
Addenbrooke's Hospital, University of Cambridge
Co-authored papers 1
Lucile Packard Children's Hospital Stanford
Co-authored papers 1
Co-authored papers 1
University of California San Francisco
Co-authored papers 1
Institute for Neurodegenerative Diseases, University of California San Francisco
Co-authored papers 1
Gladstone Institutes
Co-authored papers 1
Graduate School of Medicine, Kyoto University
Co-authored papers 1
Buck Institute for Research on Aging
Co-authored papers 1
Buck Institute for Research on Aging
Co-authored papers 1
Co-authored papers 1
Lewis Sigler Institute for Integrative Genomics, Princeton University
Co-authored papers 1
Gladstone Institutes
Co-authored papers 1
The Buck Institute for Research on Aging
Co-authored papers 1
Harvard T.H. Chan School of Public Health
Co-authored papers 1
Gladstone Institutes
Co-authored papers 1
Gladstone Institutes
Co-authored papers 1
Stanford University
Co-authored papers 1
Harvard Medical School
Co-authored papers 1
Affymax Research Institute
Co-authored papers 1
Buck Institute for Research on Aging
Co-authored papers 1
National Institute On Aging
Co-authored papers 1
Weill Institute for Neurosciences, University of California san francisco
Co-authored papers 1