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Author Details

Stephane Ferretti
Novartis Institutes for BioMedical Research
2003
34
21
PMIDPaper TitleJournal TitlePublished Year
34862243Results from a First-in-Human Phase I Study of Siremadlin (HDM201) in Patients with Advanced Wild-Type TP53 Solid Tumors and Acute Leukemia.Clin Cancer Res2022
34921024Co-Targeting of MDM2 and CDK4/6 with Siremadlin and Ribociclib for the Treatment of Patients with Well-Differentiated or Dedifferentiated Liposarcoma: Results from a Proof-of-Concept, Phase Ib Study.Clin Cancer Res2022
34140638Pharmacokinetic-pharmacodynamic guided optimisation of dose and schedule of CGM097, an HDM2 inhibitor, in preclinical and clinical studies.Br J Cancer2021
33824280CARD10 cleavage by MALT1 restricts lung carcinoma growth in vivo.Oncogenesis2021
33903593PAX8 and MECOM are interaction partners driving ovarian cancer.Nat Commun2021
33563973p53 dynamics vary between tissues and are linked with radiation sensitivity.Nat Commun2021
33615182Therapeutic Assessment of Targeting ASNS Combined with l-Asparaginase Treatment in Solid Tumors and Investigation of Resistance Mechanisms.ACS Pharmacol Transl Sci2021
33554304Translational Modeling of Anticancer Efficacy to Predict Clinical Outcomes in a First-in-Human Phase 1 Study of MDM2 Inhibitor HDM201.AAPS J2021
32099592Genetic heterogeneity and clonal evolution during metastasis in breast cancer patient-derived tumor xenograft models.Comput Struct Biotechnol J2020
30598450Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response.Proc Natl Acad Sci U S A2019
30217415In vitro and in vivo characterization of a novel, highly potent p53-MDM2 inhibitor.Bioorg Med Chem Lett2018
30135191Dose and Schedule Determine Distinct Molecular Mechanisms Underlying the Efficacy of the p53-MDM2 Inhibitor HDM201.Cancer Res2018
29092942PDX-MI: Minimal Information for Patient-Derived Tumor Xenograft Models.Cancer Res2017
28265066Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf<sup>-/-</sup> mouse model.Proc Natl Acad Sci U S A2017
27659046High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells.Cancer Res2016
27852439Correction: A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097.Elife2016
25965177A distinct p53 target gene set predicts for response to the selective p53-HDM2 inhibitor NVP-CGM097.Elife2015
26479923High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response.Nat Med2015
26181851Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors.J Med Chem2015
24321855First full-beam PET acquisitions in proton therapy with a modular dual-head dedicated system.Phys Med Biol2014
24786664Proton range monitoring with in-beam PET: Monte Carlo activity predictions and comparison with cyclotron data.Phys Med2014
24608574Characterization of the novel and specific PI3Kα inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials.Mol Cancer Ther2014
24528602Tumour T1 changes in vivo are highly predictive of response to chemotherapy and reflect the number of viable tumour cells--a preclinical MR study in mice.BMC Cancer2014
23267074M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth.Proc Natl Acad Sci U S A2013
20008843Quantified tumor t1 is a generic early-response imaging biomarker for chemotherapy reflecting cell viability.Clin Cancer Res2010
19462209Comparison of [18F]-tracers in various experimental tumor models by PET imaging and identification of an early response biomarker for the novel microtubule stabilizer patupilone.Mol Imaging Biol2009
19724681Tumor interstitial fluid pressure as an early-response marker for anticancer therapeutics.Neoplasia2009
18811057Minimally invasive biomarkers for therapy monitoring.Ernst Schering Found Symp Proc2007
16339780Effect of adenosine A2A receptor activation in murine models of respiratory disorders.Am J Physiol Lung Cell Mol Physiol2006
15723258Patupilone (epothilone B, EPO906) and imatinib (STI571, Glivec) in combination display enhanced antitumour activity in vivo against experimental rat C6 glioma.Cancer Chemother Pharmacol2005
16278399Patupilone induced vascular disruption in orthotopic rodent tumor models detected by magnetic resonance imaging and interstitial fluid pressure.Clin Cancer Res2005
15918178PTK787/ZK222584, a tyrosine kinase inhibitor of vascular endothelial growth factor receptor, reduces uptake of the contrast agent GdDOTA by murine orthotopic B16/BL6 melanoma tumours and inhibits their growth in vivo.NMR Biomed2005
12819855Differential DNA synthesis in response to activation of protease-activated receptors on cultured guinea-pig tracheal smooth muscle cells.Naunyn Schmiedebergs Arch Pharmacol2003
12574382IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger.J Immunol2003
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Collaborators

Co-authored papers 8
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Bakar Computational Health Sciences Institute, University of California san francisco
Co-authored papers 1
University Hospital Zurich
Co-authored papers 1
European Bioinformatics Institute
Co-authored papers 1
Candiolo Cancer Institute - FPO IRCCS
Co-authored papers 1
Royal College of Surgeons in Ireland (RCSI)
Co-authored papers 1
Cancer Research UK Cambridge Institute, University of Cambridge
Co-authored papers 1
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Clinical Research Division, Fred Hutchinson Cancer Center
Co-authored papers 1
Broad Institute of Harvard and MIT
Co-authored papers 1
Dana-Farber Cancer Institute
Co-authored papers 1
Co-authored papers 1
The University of Texas Health Science Center at San Antonio
Co-authored papers 1
Hopp Children's Cancer Center Heidelberg (KiTZ)
Co-authored papers 1
Co-authored papers 1
Dana-Farber Cancer Institute
Co-authored papers 1
Hopp Children's Cancer Center (KiTZ)
Co-authored papers 1
European Molecular Biology Laboratory - European Bioinformatics Institute
Co-authored papers 1
Netherlands Cancer Institute
Co-authored papers 1
Netherlands Cancer Institute
Co-authored papers 1
Biogen Inc.
Co-authored papers 1
Hopp Children's Cancer Center Heidelberg (KiTZ)
Co-authored papers 1
Oncode Institute, The Netherlands Cancer Institute
Co-authored papers 1
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Mayo Clinic
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Dana-Farber Cancer Institute
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