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Author Details

Hugh Lee Sweeney
College of Medicine, University of Florida
1984
272
80
PMIDPaper TitleJournal TitlePublished Year
37932907Clinical importance of changes in magnetic resonance biomarkers for Duchenne muscular dystrophy.Ann Clin Transl Neurol2024
36798266Blocking muscle wasting via deletion of the muscle-specific E3 ubiquitin ligase MuRF1 impedes pancreatic tumor growth.Res Sq2023
37325966Mechanisms of Skeletal Muscle Atrophy and Molecular Circuitry of Stem Cell Fate in Skeletal Muscle Regeneration and Aging.J Gerontol A Biol Sci Med Sci2023
37202741The Antiparallel Coiled-Coil Domain Allows Multiple Forward Step Sizes of Myosin X.J Phys Chem Lett2023
36995778Modulating fast skeletal muscle contraction protects skeletal muscle in animal models of Duchenne muscular dystrophy.J Clin Invest2023
36240102Evaluating Genetic Modifiers of Duchenne Muscular Dystrophy Disease Progression Using Modeling and MRI.Neurology2022
35681116Longitudinal changes in cardiac function in Duchenne muscular dystrophy population as measured by magnetic resonance imaging.BMC Cardiovasc Disord2022
37206988Evaluation of the DBA/2J mouse as a potential background strain for genetic models of cardiomyopathy.J Mol Cell Cardiol Plus2022
33394000Assessment of rAAVrh.74.MHCK7.micro-dystrophin Gene Therapy Using Magnetic Resonance Imaging in Children With Duchenne Muscular Dystrophy.JAMA Netw Open2021
33678513Disease-modifying effects of edasalonexent, an NF-κB inhibitor, in young boys with Duchenne muscular dystrophy: Results of the MoveDMD phase 2 and open label extension trial.Neuromuscul Disord2021
33762424Current state of cardiac troponin testing in Duchenne muscular dystrophy cardiomyopathy: review and recommendations from the Parent Project Muscular Dystrophy expert panel.Open Heart2021
34519272Filopodia powered by class x myosin promote fusion of mammalian myoblasts.Elife2021
34812732High-resolution structures of the actomyosin-V complex in three nucleotide states provide insights into the force generation mechanism.Elife2021
34120912A Randomized, Double-Blind, Placebo-Controlled, Global Phase 3 Study of Edasalonexent in Pediatric Patients with Duchenne Muscular Dystrophy: Results of the PolarisDMD Trial.J Neuromuscul Dis2021
32286193Upper and Lower Extremities in Duchenne Muscular Dystrophy Evaluated with Quantitative MRI and Proton MR Spectroscopy in a Multicenter Cohort.Radiology2020
32081426Simultaneous tracking of two motor domains reveals near simultaneous steps and stutter steps of myosin 10 on actin filament bundles.Biochem Biophys Res Commun2020
32024675MR biomarkers predict clinical function in Duchenne muscular dystrophy.Neurology2020
31689091Force Generation by Myosin Motors: A Structural Perspective.Chem Rev2020
31830002Glucocorticoids counteract hypertrophic effects of myostatin inhibition in dystrophic muscle.JCI Insight2020
31886717Activin type II receptor ligand signaling inhibition after experimental ischemic heart failure attenuates cardiac remodeling and prevents fibrosis.Am J Physiol Heart Circ Physiol2020
32826942The D2.mdx mouse as a preclinical model of the skeletal muscle pathology associated with Duchenne muscular dystrophy.Sci Rep2020
32184340Modeling disease trajectory in Duchenne muscular dystrophy.Neurology2020
32451853Myosin Structures.Adv Exp Med Biol2020
30452422Phase 1 Study of Edasalonexent (CAT-1004), an Oral NF-κB Inhibitor, in Pediatric Patients with Duchenne Muscular Dystrophy.J Neuromuscul Dis2019
31323135Functional muscle hypertrophy by increased insulin-like growth factor 1 does not require dysferlin.Muscle Nerve2019
30972202Smooth muscle atrophy and colon pathology in SMN deficient mice.Am J Transl Res2019
29203356226<sup>th</sup> ENMC International Workshop:: Towards validated and qualified biomarkers for therapy development for Duchenne muscular dystrophy 20-22 January 2017, Heemskerk, The Netherlands.Neuromuscul Disord2018
29907980DMD genotype correlations from the Duchenne Registry: Endogenous exon skipping is a factor in prolonged ambulation for individuals with a defined mutation subtype.Hum Mutat2018
29928867Three-dimensional contractile muscle tissue consisting of human skeletal myocyte cell line.Exp Cell Res2018
30141986Structural and functional cardiac profile after prolonged duration of mechanical unloading: potential implications for myocardial recovery.Am J Physiol Heart Circ Physiol2018
30222106Too much of a good thing.Elife2018
29844196An intermediate along the recovery stroke of myosin VI revealed by X-ray crystallography and molecular dynamics.Proc Natl Acad Sci U S A2018
30332629The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory.Immunity2018
29554116Skeletal muscle magnetic resonance biomarkers correlate with function and sentinel events in Duchenne muscular dystrophy.PLoS One2018
29419405Muscle Contraction.Cold Spring Harb Perspect Biol2018
29742798Longitudinal timed function tests in Duchenne muscular dystrophy: ImagingDMD cohort natural history.Muscle Nerve2018
29716949Motor Proteins.Cold Spring Harb Perspect Biol2018
29734234Two-Year Longitudinal Changes in Lower Limb Strength and Its Relation to Loss in Function in a Large Cohort of Patients With Duchenne Muscular Dystrophy.Am J Phys Med Rehabil2018
29365354Leg muscle MRI in identical twin boys with duchenne muscular dystrophy.Muscle Nerve2018
27879251Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections.Arterioscler Thromb Vasc Biol2017
28228973Duchenne Regulatory Science Consortium Meeting on Disease Progression Modeling for Duchenne Muscular Dystrophy.PLoS Curr2017
28270449Supraphysiological levels of GDF11 induce striated muscle atrophy.EMBO Mol Med2017
28972192A phase 3 randomized placebo-controlled trial of tadalafil for Duchenne muscular dystrophy.Neurology2017
28728956Ataluren in patients with nonsense mutation Duchenne muscular dystrophy (ACT DMD): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial.Lancet2017
26891991Multicenter prospective longitudinal study of magnetic resonance biomarkers in a large duchenne muscular dystrophy cohort.Ann Neurol2016
26616495Increased collagen cross-linking is a signature of dystrophin-deficient muscle.Muscle Nerve2016
28018975Disease-modifying effects of orally bioavailable NF-<b>κ</b>B inhibitors in dystrophin-deficient muscle.JCI Insight2016
27870893Activin Receptor Type IIB Inhibition Improves Muscle Phenotype and Function in a Mouse Model of Spinal Muscular Atrophy.PLoS One2016
27580874The myosin X motor is optimized for movement on actin bundles.Nat Commun2016
27717739How Myosin Generates Force on Actin Filaments.Trends Biochem Sci2016
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Collaborators

College of Medicine, University of Florida
Co-authored papers 36
University of Florida
Co-authored papers 32
College of Public Health and Health Professions, University of Florida
Co-authored papers 18
Center for Experimental Neurotherapeutics, St. Jude Children's Research Hospital
Co-authored papers 16
University of Florida
Co-authored papers 15
Stanford University
Co-authored papers 13
Co-authored papers 12
Co-authored papers 8
Co-authored papers 6
University of California
Co-authored papers 5
Co-authored papers 3
Institute for Fundamental Biomedical Research, Johns Hopkins All Children's Hospital
Co-authored papers 3
university of california los angeles
Co-authored papers 3
University of Florida
Co-authored papers 3
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
Harvard Medical School
Co-authored papers 2
and Clinical Center
Co-authored papers 2
Co-authored papers 2
University of Debrecen
Co-authored papers 2
College of Health and Human Performance, University of Florida
Co-authored papers 2
Brigham and Women's Hospital (Y.K.
Co-authored papers 2
American College of Medical Informatics, Department of Veteran Affairs, Harvard University T H Chan School of Public Health, Massachusetts Institute of Technology, The American Society for Clinical Investigation, University of Kentucky, Vanderbilt University Medical Center, Vanderbilt University Medical School
Co-authored papers 2
National Heart Lung and Blood Institute, National Institutes of Health
Co-authored papers 1
Co-authored papers 1
Co-authored papers 1
Columbia University
Co-authored papers 1
Co-authored papers 1
Montreal Children's Hospital, McGill University
Co-authored papers 1