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Author Details

David E Levy
NYU Grossman School of Medicine
1979
194
96
PMIDPaper TitleJournal TitlePublished Year
37526084Donor T cell STAT3 deficiency enables tissue PD-L1-dependent prevention of graft-versus-host disease while preserving graft-versus-leukemia activity.J Clin Invest2023
35799901Assessing the Presence of Hematopoietic Stem and Progenitor Cells in Mouse Spleen.Bio Protoc2022
34124936The Cyclin-Dependent Kinase 8 (CDK8) Inhibitor DCA Promotes a Tolerogenic Chemical Immunophenotype in CD4<sup>+</sup> T Cells via a Novel CDK8-GATA3-FOXP3 Pathway.Mol Cell Biol2021
33605027Mitochondrial STAT3 regulates antioxidant gene expression through complex I-derived NAD in triple negative breast cancer.Mol Oncol2021
34378531Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome.Elife2021
34507993IL-6 enhances CD4 cell motility by sustaining mitochondrial Ca<sup>2+</sup> through the noncanonical STAT3 pathway.Proc Natl Acad Sci U S A2021
33305182STAT3 Inhibitor OPB-51602 Is Cytotoxic to Tumor Cells Through Inhibition of Complex I and ROS Induction.iScience2020
30463877HDAC stimulates gene expression through BRD4 availability in response to IFN and in interferonopathies.J Exp Med2018
28584133Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells.Proc Natl Acad Sci U S A2017
28356390The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity.J Exp Med2017
26904939Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation.Cell Rep2016
27127173Cytoplasmic, full length and novel cleaved variant, TBLR1 reduces apoptosis in prostate cancer under androgen deprivation.Oncotarget2016
26939124PKR Transduces MDA5-Dependent Signals for Type I IFN Induction.PLoS Pathog2016
26198641STAT3 regulated ARF expression suppresses prostate cancer metastasis.Nat Commun2015
26499136Erratum: STAT3 regulated ARF expression suppresses prostate cancer metastasis.Nat Commun2015
26283727A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3.Mol Cell Biol2015
25150294STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation.Blood2014
22785228STAT1-regulated lung MDSC-like cells produce IL-10 and efferocytose apoptotic neutrophils with relevance in resolution of bacterial pneumonia.Mucosal Immunol2013
24312439The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformation.PLoS One2013
23878400The human RVB complex is required for efficient transcription of type I interferon-stimulated genes.Mol Cell Biol2013
22159083Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function.Am J Physiol Cell Physiol2012
24058748Comparative evolutionary genomics of the STAT family of transcription factors.JAKSTAT2012
22520849STATus report on tetramers.Immunity2012
22679098Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface.Science2012
22312003Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export.J Cell Biol2012
22252317Contribution of a TANK-binding kinase 1-interferon (IFN) regulatory factor 7 pathway to IFN-γ-induced gene expression.Mol Cell Biol2012
22264274STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas.Breast Cancer Res2012
22365663Constitutive type I interferon modulates homeostatic balance through tonic signaling.Immunity2012
21215659The transcription factor STAT3 is required for T helper 2 cell development.Immunity2011
22323926Induction and function of type I and III interferon in response to viral infection.Curr Opin Virol2011
21810606STAT3 negatively regulates type I IFN-mediated antiviral response.J Immunol2011
21586612STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.Cancer Res2011
21730287Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis.Mol Cell Biol2011
21730023TLR4 engagement during TLR3-induced proinflammatory signaling in dendritic cells promotes IL-10-mediated suppression of antitumor immunity.Cancer Res2011
21339641Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-α-producing and partially matured phenotype.J Clin Invest2011
21505191STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis.Blood2011
21219575Distinct inflammatory signals have physiologically divergent effects on epigenetic regulation of Foxp3 expression and Treg function.Am J Transplant2011
20436908Functional crosstalk between type I and II interferon through the regulated expression of STAT1.PLoS Biol2010
21084727A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction.Aging (Albany NY)2010
20829794A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells.Nature2010
20643331NF-kappaB-ISGF3 transcription factor cooperation: coincidence detector or memory chip?Immunity2010
19234181IL-21 mediates suppressive effects via its induction of IL-10.J Immunol2009
19956438Activation of Stat3 in renal tumors.Am J Transl Res2009
20064451Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors.Immunity2009
19690134Identification of a Stat3-dependent transcription regulatory network involved in metastatic progression.Cancer Res2009
19608706Reduction of Stat3 activity attenuates HIV-induced kidney injury.J Am Soc Nephrol2009
19604309Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells.Immunology2009
19357722Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy.Kidney Int2009
19414776c-Maf regulates IL-10 expression during Th17 polarization.J Immunol2009
19556508Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.Science2009
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Collaborators

Centre Hospitalo-Universitaire de Rouen
Co-authored papers 24
University of Vienna
Co-authored papers 11
Co-authored papers 9
Icahn School of Medicine at Mount Sinai
Co-authored papers 6
University of Texas Southwestern Medical Center
Co-authored papers 5
Meyer Cancer Center, Weill Cornell Medicine and New York Presbyterian Hospital
Co-authored papers 4
Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna
Co-authored papers 3
The University of Melbourne
Co-authored papers 3
Co-authored papers 2
Co-authored papers 2
Center for Cancer Research, National Cancer Institute, National Institutes of Health
Co-authored papers 2
Co-authored papers 2
Universidade Federal de Santa Maria
Co-authored papers 2
Icahn School of Medicine at Mount Sinai
Co-authored papers 2
Co-authored papers 2
Icahn School of Medicine at Mount Sinai
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 2
Co-authored papers 1
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Co-authored papers 1
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the University of Texas MD Anderson Cancer Center
Co-authored papers 1
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Co-authored papers 1
Massachusetts General Hospital
Co-authored papers 1
Center for the Science of Therapeutics, Broad Institute
Co-authored papers 1
Broad Institute of MIT and Harvard
Co-authored papers 1
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University of Michigan ann arbor
Co-authored papers 1