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Author Details

Paola Picotti
Institute of Molecular Systems Biology, ETH Zurich
2004
109
43
Emma Lundberg (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36178621Limited Proteolysis-Mass Spectrometry to Identify Metabolite-Protein Interactions.Methods Mol Biol2023
37562848ATP-independent substrate recruitment to proteasomal degradation in mycobacteria.Life Sci Alliance2023
37485750Genetic effects on molecular network states explain complex traits.Mol Syst Biol2023
37699397Global analysis of aging-related protein structural changes uncovers enzyme-polymerization-based control of longevity.Mol Cell2023
37647412Structures of wild-type and selected CMT1X mutant connexin 32 gap junction channels and hemichannels.Sci Adv2023
37535063Structure of the connexin-43 gap junction channel in a putative closed state.Elife2023
37011209Structural basis of calmodulin modulation of the rod cyclic nucleotide-gated channel.Proc Natl Acad Sci U S A2023
36653529Author Correction: Proteome-wide structural changes measured with limited proteolysis-mass spectrometry: an advanced protocol for high-throughput applications.Nat Protoc2023
36526727Proteome-wide structural changes measured with limited proteolysis-mass spectrometry: an advanced protocol for high-throughput applications.Nat Protoc2023
34702981Author Correction: Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly.Nat Cell Biol2022
35396578Author Correction: Combining CRISPRi and metabolomics for functional annotation of compound libraries.Nat Chem Biol2022
36432905Environmental Signals Act as a Driving Force for Metabolic and Defense Responses in the Antarctic Plant <i>Colobanthus quitensis</i>.Plants (Basel)2022
36417879Calreticulin mutations affect its chaperone function and perturb the glycoproteome.Cell Rep2022
36045419Comparative analysis of cancer cell responses to targeted radionuclide therapy (TRT) and external beam radiotherapy (EBRT).J Hematol Oncol2022
36224378Global, in situ analysis of the structural proteome in individuals with Parkinson's disease to identify a new class of biomarker.Nat Struct Mol Biol2022
35980026Structure of <i>Mycobacterium tuberculosis</i> Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases.Elife2022
35194207Combining CRISPRi and metabolomics for functional annotation of compound libraries.Nat Chem Biol2022
33357446Dynamic 3D proteomes reveal protein functional alterations at high resolution in situ.Cell2021
36699412protti: an R package for comprehensive data analysis of peptide- and protein-centric bottom-up proteomics data.Bioinform Adv2021
33932331Deciphering the signaling network of breast cancer improves drug sensitivity prediction.Cell Syst2021
34616026Reversible amyloids of pyruvate kinase couple cell metabolism and stress granule disassembly.Nat Cell Biol2021
34155216Systematic detection of functional proteoform groups from bottom-up proteomic datasets.Nat Commun2021
32535145Comparative analysis of the intracellular responses to disease-related aggregation-prone proteins.J Proteomics2020
31841731Mass spectrometry analysis of the structural proteome.Curr Opin Struct Biol2020
32826910A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes.Nat Commun2020
32419904Combining data integration and molecular dynamics for target identification in α-Synuclein-aggregating neurodegenerative diseases: Structural insights on Synaptojanin-1 (Synj1).Comput Struct Biotechnol J2020
32475682Detecting Protein-Small Molecule Interactions Using Limited Proteolysis-Mass Spectrometry (LiP-MS).Trends Biochem Sci2020
32319721Pyruvate kinase variant of fission yeast tunes carbon metabolism, cell regulation, growth and stress resistance.Mol Syst Biol2020
32129764USP16 counteracts mono-ubiquitination of RPS27a and promotes maturation of the 40S ribosomal subunit.Elife2020
30559480TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates.Nat Neurosci2019
31562479Voices in methods development.Nat Methods2019
31351878Network Rewiring of Homologous Recombination Enzymes during Mitotic Proliferation and Meiosis.Mol Cell2019
31521608Proteomics-Based Monitoring of Pathway Activity Reveals that Blocking Diacylglycerol Biosynthesis Rescues from Alpha-Synuclein Toxicity.Cell Syst2019
31406386Publisher Correction: Systems NMR: single-sample quantification of RNA, proteins and metabolites for biomolecular network analysis.Nat Methods2019
31363225Systems NMR: single-sample quantification of RNA, proteins and metabolites for biomolecular network analysis.Nat Methods2019
31167929A cullin-RING ubiquitin ligase targets exogenous α-synuclein and inhibits Lewy body-like pathology.Sci Transl Med2019
29307493A Map of Protein-Metabolite Interactions Reveals Principles of Chemical Communication.Cell2018
29911972The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.Elife2018
30137990Biology/Disease-Driven Initiative on Protein-Aggregation Diseases of the Human Proteome Project: Goals and Progress to Date.J Proteome Res2018
30531974Phosphorylation of nuclear Tau is modulated by distinct cellular pathways.Sci Rep2018
29467300High-throughput metabolomic analysis predicts mode of action of uncharacterized antimicrobial compounds.Sci Transl Med2018
29453283Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides.J Biol Chem2018
28846094Reversible protein aggregation is a protective mechanism to ensure cell cycle restart after stress.Nat Cell Biol2017
28232526Cell-wide analysis of protein thermal unfolding reveals determinants of thermostability.Science2017
29229832FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome.Proc Natl Acad Sci U S A2017
29072706Measuring protein structural changes on a proteome-wide scale using limited proteolysis-coupled mass spectrometry.Nat Protoc2017
29065306Mitotic Disassembly of Nuclear Pore Complexes Involves CDK1- and PLK1-Mediated Phosphorylation of Key Interconnecting Nucleoporins.Dev Cell2017
26700040Selected Reaction Monitoring to Measure Proteins of Interest in Complex Samples: A Practical Guide.Methods Mol Biol2016
26503344Relative Infestation Level and Sensitivity of Grapevine Cultivars to the Leafhopper Empoasca vitis (Hemiptera: Cicadellidae).J Econ Entomol2016
27796354Corrigendum: Cortical dynamics during cell motility are regulated by CRL3<sup>KLHL21</sup> E3 ubiquitin ligase.Nat Commun2016
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Collaborators

Ruedi Aebersold
Institute of Molecular Systems Biology, ETH Zurich
Co-authored papers 28
Lukas Reiter
Co-authored papers 13
Matthias Peter
Institute of Biochemistry, ETH Zurich
Co-authored papers 11
Andreas Beyer
University of Cologne
Co-authored papers 6
Bruno Domon
Co-authored papers 6
David S Campbell
Co-authored papers 6
Ludovic Gillet
ETH Zurich
Co-authored papers 5
Bernd Bodenmiller
University of Zurich
Co-authored papers 5
Mi-Youn Brusniak
Co-authored papers 4
Eric W Deutsch
Institute for Systems Biology
Co-authored papers 4
Roland Riek
ETH Zurich
Co-authored papers 4
Olga Vitek
Khoury College of Computer Sciences, Northeastern University
Co-authored papers 4
Abdullah Kahraman
University of Zurich
Co-authored papers 4
Ulrike Kusebauch
Institute for Systems Biology
Co-authored papers 3
Christian von Mering
Co-authored papers 3
Bernd Wollscheid
ETH Zurich
Co-authored papers 3
Ruth H??ttenhain
Quantitative Biosciences Institute (QBI), University of California san francisco
Co-authored papers 3
Robert L Moritz
Institute for Systems Biology
Co-authored papers 3
Garry P Nolan
Stanford University School of Medicine
Co-authored papers 2
John D Aitchison
Center for Global Infectious Disease Research, Seattle Children's Research Institute
Co-authored papers 2
Julio Saez-Rodriguez
Institute of Computational Biomedicine, Heidelberg University
Co-authored papers 2
Nicholas J Loman
University of Birmingham
Co-authored papers 2
J??rg B??hler
University College London
Co-authored papers 2
Susan Lindquist
Whitehead Institute for Biomedical Research
Co-authored papers 2
Eliezer Masliah
National Institute On Aging
Co-authored papers 2
Vincenzo De Filippis
Department of Pharmaceutical and Pharmacological Sciences, University of Padua
Co-authored papers 2
Jeffrey A Ranish
Institute for Systems Biology
Co-authored papers 2
Henning Stahlberg
Ecole Polytechnique Federale de Lausanne (EPFL), University of Lausanne
Co-authored papers 2
Luke Whitesell
University of Toronto
Co-authored papers 2
Gy??rgy Marko-Varga
Clinical Protein Science & Imaging, Biomedical Centre, Lund University
Co-authored papers 2
Release 1.2