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Author Details

Deborah K Morrison
Center for Cancer Research, National Cancer Institute-Frederick
1985
126
61
PMIDPaper TitleJournal TitlePublished Year
37590148Protocol for measuring BRAF autoinhibition in live cells using a proximity-based NanoBRET assay.STAR Protoc2023
35078985Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding.Nat Commun2022
35672316Enhanced BRAF engagement by NRAS mutants capable of promoting melanoma initiation.Nat Commun2022
35696348Tolypocladamides A-G: Cytotoxic Peptaibols from <i>Tolypocladium inflatum</i>.J Nat Prod2022
36347258RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation.Mol Cell2022
35046094A Structure is Worth a Thousand Words: New Insights for RAS and RAF Regulation.Cancer Discov2022
33158997Rigosertib Induces Mitotic Arrest and Apoptosis in RAS-Mutated Rhabdomyosarcoma and Neuroblastoma.Mol Cancer Ther2021
33495197TNIK Is a Therapeutic Target in Lung Squamous Cell Carcinoma and Regulates FAK Activation through Merlin.Cancer Discov2021
34158349Development of a High-throughput NanoBRET Screening Platform to Identify Modulators of the RAS/RAF Interaction.Mol Cancer Ther2021
32191460Swinhopeptolides A and B: Cyclic Depsipeptides from the Sponge <i>Theonella swinhoei</i> That Inhibit Ras/Raf Interaction.J Nat Prod2020
31913576Advancing RAS/RASopathy therapies: An NCI-sponsored intramural and extramural collaboration for the study of RASopathies.Am J Med Genet A2020
29358316Ras-Mediated Activation of the Raf Family Kinases.Cold Spring Harb Perspect Med2019
31606273Distinct Binding Preferences between Ras and Raf Family Members and the Impact on Oncogenic Ras Signaling.Mol Cell2019
31204173Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis.Dev Cell2019
30808747M-Ras/Shoc2 signaling modulates E-cadherin turnover and cell-cell adhesion during collective cell migration.Proc Natl Acad Sci U S A2019
29235562Targeting the Raf kinases in human cancer: the Raf dimer dilemma.Br J Cancer2018
30181243Oncogenic RAS isoforms show a hierarchical requirement for the guanine nucleotide exchange factor SOS2 to mediate cell transformation.Sci Signal2018
29979591Macrophilones from the Marine Hydroid Macrorhynchia philippina Can Inhibit ERK Cascade Signaling.J Nat Prod2018
30324102Synthesis and Biological Evaluation of New Madecassic Acid Derivatives Targeting ERK Cascade Signaling.Front Chem2018
29259016Oncogenic RAS-Induced Perinuclear Signaling Complexes Requiring KSR1 Regulate Signal Transmission to Downstream Targets.Cancer Res2018
29089450MARK3-mediated phosphorylation of ARHGEF2 couples microtubules to the actin cytoskeleton to establish cell polarity.Sci Signal2017
29021281Survival of BRCA2-Deficient Cells Is Promoted by <i>GIPC3</i>, a Novel Genetic Interactor of <i>BRCA2</i>.Genetics2017
28947418KIT Suppresses BRAF<sup>V600E</sup>-Mutant Melanoma by Attenuating Oncogenic RAS/MAPK Signaling.Cancer Res2017
27226552Protein Kinase CK2α Maintains Extracellular Signal-regulated Kinase (ERK) Activity in a CK2α Kinase-independent Manner to Promote Resistance to Inhibitors of RAF and MEK but Not ERK in BRAF Mutant Melanoma.J Biol Chem2016
27984577RAS signaling: Divide and conquer.Nat Chem Biol2016
27889448Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit.Mol Cell2016
25735773Loss of MIG6 Accelerates Initiation and Progression of Mutant Epidermal Growth Factor Receptor-Driven Lung Adenocarcinoma.Cancer Discov2015
26373275Path Forward for RAF Therapies: Inhibition of Monomers and Dimers.Cancer Cell2015
24656827The CNK2 scaffold interacts with vilse and modulates Rac cycling during spine morphogenesis in hippocampal neurons.Curr Biol2014
24825906EphrinB1 interacts with CNK1 and promotes cell migration through c-Jun N-terminal kinase (JNK) activation.J Biol Chem2014
23352452Effects of Raf dimerization and its inhibition on normal and disease-associated Raf signaling.Mol Cell2013
23985533The importance of Raf dimerization in cell signaling.Small GTPases2013
23575666FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4.Nat Commun2013
22037769Identification of a Src tyrosine kinase/SIAH2 E3 ubiquitin ligase pathway that regulates C/EBPδ expression and contributes to transformation of breast tumor cells.Mol Cell Biol2012
23250398A CC-SAM, for coiled coil-sterile α motif, domain targets the scaffold KSR-1 to specific sites in the plasma membrane.Sci Signal2012
22981863LAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation.Mol Cell2012
23125017MAP kinase pathways.Cold Spring Harb Perspect Biol2012
22474259Complexity in the signaling network: insights from the use of targeted inhibitors in cancer therapy.Genes Dev2012
21458265RAF inhibitor-induced KSR1/B-RAF binding and its effects on ERK cascade signaling.Curr Biol2011
22292131Complexity in KSR function revealed by Raf inhibitor and KSR structure studies.Small GTPases2011
2188481314-3-3 Proteins: diverse functions in cell proliferation and cancer progression.Semin Cell Dev Biol2011
19933846Impact of feedback phosphorylation and Raf heterodimerization on normal and mutant B-Raf signaling.Mol Cell Biol2010
21102438AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade.Nat Cell Biol2010
20811992Proteomic analysis of scaffold proteins in the ERK cascade.Methods Mol Biol2010
20805509CCAAT/enhancer binding protein delta (C/EBPdelta, CEBPD)-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage.Proc Natl Acad Sci U S A2010
20634316The CNK1 scaffold binds cytohesins and promotes insulin pathway signaling.Genes Dev2010
19027299The 14-3-3 proteins: integrators of diverse signaling cues that impact cell fate and cancer development.Trends Cell Biol2009
19883615KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity.Cell Metab2009
19560418KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals.Mol Cell2009
19541618Signaling dynamics of the KSR1 scaffold complex.Proc Natl Acad Sci U S A2009
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Collaborators

Gerald M Rubin
The University of Florida
Co-authored papers 6
Angela Cacace
O.W.) and University of Rochester Medical Center
Co-authored papers 3
Thomas P Conrads
Women's Health Integrated Research Center, Inova Health System
Co-authored papers 3
Christopher J Westlake
Center for Cancer Research
Co-authored papers 3
Robert M Stephens
Frederick National Laboratory for Cancer Research, Inc.
Co-authored papers 3
Norbert Perrimon
Co-authored papers 3
Brian J Druker
Oregon Health & Science University
Co-authored papers 2
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Co-authored papers 2
Vijay Walia
National Center for Toxicological Research
Co-authored papers 2
Robert E Lewis
University of Nebraska Medical Center
Co-authored papers 2
Peter Li
Co-authored papers 1
Patricia S Steeg
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Co-authored papers 1
Brian Raught
Princess Margaret Cancer Centre, University Health Network
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Peter Brokstein
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Joan S Brugge
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Tony Pawson
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University of Washington
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Andrei Gabrielian
National Institutes of Allergy and Infectious Diseases
Co-authored papers 1
Michael Ashburner
University of Cambridge
Co-authored papers 1
Erica A Golemis
Co-authored papers 1
Reed A George
Howard Hughes Medical Institute
Co-authored papers 1
George L Gabor Miklos
Monash University at Cabrini Health
Co-authored papers 1
Wei Xu
Princess Margaret Cancer Centre
Co-authored papers 1
R F Galle
Co-authored papers 1
M P Skupski
National Center for Genome Resources
Co-authored papers 1
Susan E Celniker
Lawrence Berkeley National Laboratory
Co-authored papers 1
William C Reinhold
Center for Cancer Research, National Cancer Institute
Co-authored papers 1
J Zhang
Co-authored papers 1
Anne-Claude Gingras
Lunenfeld-Tanenbaum Research Institute
Co-authored papers 1
Release 1.2