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Author Details

Roger A Kroes
Falk Center for Molecular Therapeutics, Northwestern University
1989
59
30
Emma Lundberg (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
31376158NYX-2925 induces metabotropic N-methyl-d-aspartate receptor (NMDAR) signaling that enhances synaptic NMDAR and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor.J Neurochem2020
30544218Positive N-Methyl-D-Aspartate Receptor Modulation by Rapastinel Promotes Rapid and Sustained Antidepressant-Like Effects.Int J Neuropsychopharmacol2019
31909296The NMDAR modulator NYX-2925 alleviates neuropathic pain via a Src-dependent mechanism in the mPFC.Neurobiol Pain2019
31373964Rat ultrasonic vocalizations as a measure of the emotional component of chronic pain.Neuroreport2019
31392357A translational EEG-based approach to assess modulation of long-lasting NMDAR-dependent synaptic plasticity.Psychopharmacology (Berl)2019
31504971NMDAR activation regulates the daily rhythms of sleep and mood.Sleep2019
29099938NYX-2925 Is a Novel NMDA Receptor-Specific Spirocyclic-β-Lactam That Modulates Synaptic Plasticity Processes Associated with Learning and Memory.Int J Neuropsychopharmacol2018
26997507The Development of Rapastinel (Formerly GLYX-13); A Rapid Acting and Long Lasting Antidepressant.Curr Neuropharmacol2017
28158790IGFBP2 Produces Rapid-Acting and Long-Lasting Effects in Rat Models of Posttraumatic Stress Disorder via a Novel Mechanism Associated with Structural Plasticity.Int J Neuropsychopharmacol2017
28957945Rough-and-tumble play induces resilience to stress in rats.Neuroreport2017
26955966Towards the Molecular Foundations of Glutamatergic-targeted Antidepressants.Curr Neuropharmacol2017
27510958The role of DNA methylation in ST6Gal1 expression in gliomas.Glycobiology2016
25369122Use of ENCODE resources to characterize novel proteoforms and missing proteins in the human proteome.J Proteome Res2015
26374350Insulin-Like Growth Factor I Produces an Antidepressant-Like Effect and Elicits N-Methyl-D-Aspartate Receptor Independent Long-Term Potentiation of Synaptic Transmission in Medial Prefrontal Cortex and Hippocampus.Int J Neuropsychopharmacol2015
26343295The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus.Neuroscience2015
26210936Rapastinel (GLYX-13) has therapeutic potential for the treatment of post-traumatic stress disorder: Characterization of a NMDA receptor-mediated metaplasticity process in the medial prefrontal cortex of rats.Behav Brain Res2015
26185906Integrated Transcriptomic and Glycomic Profiling of Glioma Stem Cell Xenografts.J Proteome Res2015
26076068Quest for Missing Proteins: Update 2015 on Chromosome-Centric Human Proteome Project.J Proteome Res2015
23800968Integrative biological analysis for neuropsychopharmacology.Neuropsychopharmacology2014
24251380GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists.Expert Opin Investig Drugs2014
24266786Integrated chromosome 19 transcriptomic and proteomic data sets derived from glioma cancer stem-cell lines.J Proteome Res2014
23303054GLYX-13, a NMDA receptor glycine-site functional partial agonist, induces antidepressant-like effects without ketamine-like side effects.Neuropsychopharmacology2013
23878504Diabetes changes expression of genes related to glutamate neurotransmission and transport in the Long-Evans rat retina.Mol Vis2013
23249167Chromosome 19 annotations with disease speciation: a first report from the Global Research Consortium.J Proteome Res2013
22552186Increasing SK2 channel activity impairs associative learning.J Neurophysiol2012
20937325Effects of intraaccumbens amphetamine on production of 50 kHz vocalizations in three lines of selectively bred Long-Evans rats.Behav Brain Res2011
21867727Motor and locomotor responses to systemic amphetamine in three lines of selectively bred Long-Evans rats.Pharmacol Biochem Behav2011
21718719A novel NMDA receptor glycine-site partial agonist, GLYX-13, has therapeutic potential for the treatment of autism.Neurosci Biobehav Rev2011
21645591Positive emotional learning is regulated in the medial prefrontal cortex by GluN2B-containing NMDA receptors.Neuroscience2011
21424270Regional changes in gene expression after limbic kindling.Cell Mol Neurobiol2011
19557511Polar lipid remodeling and increased sulfatide expression are associated with the glioma therapeutic candidates, wild type p53 elevation and the topoisomerase-1 inhibitor, irinotecan.Glycoconj J2010
20616019Overexpression of ST6GalNAcV, a ganglioside-specific alpha2,6-sialyltransferase, inhibits glioma growth in vivo.Proc Natl Acad Sci U S A2010
20199106Glycomic and transcriptomic response of GSC11 glioblastoma stem cells to STAT3 phosphorylation inhibition and serum-induced differentiation.J Proteome Res2010
20350589Uncovering the molecular basis of positive affect using rough-and-tumble play in rats: a role for insulin-like growth factor I.Neuroscience2010
18819097The effects of selective breeding for differential rates of 50-kHz ultrasonic vocalizations on emotional behavior in rats.Dev Psychobiol2009
19831842The glycobiology of brain tumors: disease relevance and therapeutic potential.Expert Rev Neurother2009
19204789Gene expression patterns in hypoxic and post-hypoxic adult rat retina with special reference to the NMDA receptor and its interactome.Mol Vis2009
18393285Rats selectively bred for low levels of 50 kHz ultrasonic vocalizations exhibit alterations in early social motivation.Dev Psychobiol2008
19014259Ultrasonic vocalizations of rats (Rattus norvegicus) during mating, play, and aggression: Behavioral concomitants, relationship to reward, and self-administration of playback.J Comp Psychol2008
17449117Neurobiology of 50-kHz ultrasonic vocalizations in rats: electrode mapping, lesion, and pharmacology studies.Behav Brain Res2007
17986135Focused microarray analysis of glyco-gene expression in human glioblastomas.J Neurochem2007
18085890Brain regional neuropeptide changes resulting from social defeat.Behav Neurosci2007
17452055Social defeat, a paradigm of depression in rats that elicits 22-kHz vocalizations, preferentially activates the cholinergic signaling pathway in the periaqueductal gray.Behav Brain Res2007
16289586Modeling depression: social dominance-submission gene expression patterns in rat neocortex.Neuroscience2006
16847945Distinct patterns of gene expression in the left and right hippocampal formation of developing rats.Hippocampus2006
16143427Regional brain cholecystokinin changes as a function of rough-and-tumble play behavior in adolescent rats.Peptides2006
15674533Breeding for 50-kHz positive affective vocalization in rats.Behav Genet2005
15464747Regional brain cholecystokinin changes as a function of friendly and aggressive social interactions in rats.Brain Res2004
12496741Comparative approaches in evolutionary psychology: molecular neuroscience meets the mind.Neuro Endocrinol Lett2002
12174869Clinical and cell line specific expression profiles of a human gene identified in experimental central nervous system metastases.Anticancer Res2002
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Collaborators

Lund University
Co-authored papers 10
The University of Texas M.D. Anderson Cancer Center
Co-authored papers 6
Clinical Protein Science & Imaging, Biomedical Centre, Lund University
Co-authored papers 4
Karolinska Institutet
Co-authored papers 4
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Co-authored papers 3
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Co-authored papers 3
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Co-authored papers 3
NYU Grossman School of Medicine
Co-authored papers 3
Institute for Systems Genetics, NYU Grossman School of Medicine
Co-authored papers 3
Virginia Commonwealth University
Co-authored papers 3
Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL)
Co-authored papers 3
KTH Royal Institute of Technology
Co-authored papers 3
Northeastern University
Co-authored papers 2
The University of Texas MD Anderson Cancer Center
Co-authored papers 2
and School of Public Health, University of Michigan ann arbor
Co-authored papers 2
Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL)
Co-authored papers 2
Huntsman Cancer Institute, University of Utah
Co-authored papers 2
University of California san francisco
Co-authored papers 2
College of Life Sciences and Biotechnology, Yonsei University
Co-authored papers 2
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Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL)
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Institute of Chemistry, Federal University of Rio de Janeiro
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Anhui Medical University
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Groningen Research Institute of Pharmacy, University of Groningen
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Institute of Biomedical Chemistry
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Monash University
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Cancer Research Center (CSIC/USAL/IBSAL)
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