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Author Details

Cate Speake
Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason
2009
83
24
PMIDPaper TitleJournal TitlePublished Year
36227635Risk Modeling to Reduce Monitoring of an Autoantibody-Positive Population to Prevent DKA at Type 1 Diabetes Diagnosis.J Clin Endocrinol Metab2023
37758901Shifts in isoform usage underlie transcriptional differences in regulatory T cells in type 1 diabetes.Commun Biol2023
37751304Islet-autoreactive CD4+ T cells are linked with response to alefacept in type 1 diabetes.JCI Insight2023
37520758ABCC8-Related Monogenic Diabetes Presenting Like Type 1 Diabetes in an Adolescent.AACE Clin Case Rep2023
37794253Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine.Nat Med2023
37886513Self-reactive germline-like TCR alpha chains shared between blood and pancreas.Res Sq2023
37940642A standardized metric to enhance clinical trial design and outcome interpretation in type 1 diabetes.Nat Commun2023
38096190Testing a new platform to screen disease-modifying therapy in type 1 diabetes.PLoS One2023
37572381OGTT Metrics Surpass Continuous Glucose Monitoring Data for T1D Prediction in Multiple-Autoantibody-Positive Individuals.J Clin Endocrinol Metab2023
37406136Measuring anti-islet autoimmunity in mouse and human by profiling peripheral blood antigen-specific CD4 T cells.Sci Transl Med2023
37338983Diminished responses to mRNA-based SARS-CoV-2 vaccines in individuals with rheumatoid arthritis on immune-modifying therapies.JCI Insight2023
37205332Mediators of monocyte chemotaxis and matrix remodeling are associated with the development of fibrosis in patients with COVID-19.medRxiv2023
37202589Approval of teplizumab: implications for patients.Nat Rev Endocrinol2023
37474341Technical Validation and Utility of an HLA Class II Tetramer Assay for Type 1 Diabetes: A Multicenter Study.J Clin Endocrinol Metab2023
36703975Characterizing T cell responses to enzymatically modified beta cell neo-epitopes.Front Immunol2023
36894554SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity.Nat Commun2023
36201618Recognition of mRNA Splice Variant and Secretory Granule Epitopes by CD4+ T Cells in Type 1 Diabetes.Diabetes2023
35020411Deep immune phenotyping reveals similarities between aging, Down syndrome, and autoimmunity.Sci Transl Med2022
35767821The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopes.PLoS Pathog2022
35388005Citrullination of glucokinase is linked to autoimmune diabetes.Nat Commun2022
36177823ISPAD Clinical Practice Consensus Guidelines 2022: Stages of type 1 diabetes in children and adolescents.Pediatr Diabetes2022
36206464Standard Operating Procedures for Biospecimen Collection, Processing, and Storage: From the Type 1 Diabetes in Acute Pancreatitis Consortium.Pancreas2022
36206461Assessing the Pathophysiology of Hyperglycemia in the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium.Pancreas2022
36206462Evaluating the Immunopathogenesis of Diabetes After Acute Pancreatitis in the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: From the Type 1 Diabetes in Acute Pancreatitis Consortium.Pancreas2022
36206460Rationale and Design for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study: A Prospective Cohort Study From the Type 1 Diabetes in Acute Pancreatitis Consortium.Pancreas2022
36098405Severe acute pancreatitis exhibits distinct cytokine signatures and trajectories in humans: a prospective observational study.Am J Physiol Gastrointest Liver Physiol2022
36282595IL-6-targeted therapies to block the cytokine or its receptor drive distinct alterations in T cell function.JCI Insight2022
35288472Cutting Edge: Effect of Disease-Modifying Therapies on SARS-CoV-2 Vaccine-Induced Immune Responses in Multiple Sclerosis Patients.J Immunol2022
35313588The SARS-CoV-2 Delta variant induces an antibody response largely focused on class 1 and 2 antibody epitopes.bioRxiv2022
35041021Characterising the age-dependent effects of risk factors on type 1 diabetes progression.Diabetologia2022
35025103Guidelines for standardizing T-cell cytometry assays to link biomarkers, mechanisms, and disease outcomes in type 1 diabetes.Eur J Immunol2022
35022272Fewer LAG-3<sup>+</sup> T Cells in Relapsing-Remitting Multiple Sclerosis and Type 1 Diabetes.J Immunol2022
34342578Endomembrane targeting of human OAS1 p46 augments antiviral activity.Elife2021
33881515Advances in Type 1 Diabetes Prediction Using Islet Autoantibodies: Beyond a Simple Count.Endocr Rev2021
33483981The many faces of islet antigen-specific CD8 T cells: clues to clinical outcome in type 1 diabetes.Immunol Cell Biol2021
33917702Early Prognostic Indicators of Subsequent Hospitalization in Patients with Mild COVID-19.J Clin Med2021
33662335Combination therapy in recent-onset type 1 diabetes.Lancet Diabetes Endocrinol2021
34806648Autoreactive T cell receptors with shared germline-like α chains in type 1 diabetes.JCI Insight2021
31557315In-vivo assessment of T cell kinetics in individuals at risk for type 1 diabetes.Clin Exp Immunol2020
31815738Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression.J Clin Invest2020
31907557Hyaluronan deposition in islets may precede and direct the location of islet immune-cell infiltrates.Diabetologia2020
32019856Autoantibody Reversion: Changing Risk Categories in Multiple-Autoantibody-Positive Individuals.Diabetes Care2020
31826866Insulin-Like Growth Factor Dysregulation Both Preceding and Following Type 1 Diabetes Diagnosis.Diabetes2020
31913467Circulating Unmethylated Insulin DNA As a Biomarker of Human Beta Cell Death: A Multi-laboratory Assay Comparison.J Clin Endocrinol Metab2020
33186361Sensitive detection of multiple islet autoantibodies in type 1 diabetes using small sample volumes by agglutination-PCR.PLoS One2020
32573495Multiplexing DNA methylation markers to detect circulating cell-free DNA derived from human pancreatic β cells.JCI Insight2020
32669415Response to Comment on So et al. Autoantibody Reversion: Changing Risk Categories in Multiple-Autoantibody-Positive Individuals. Diabetes Care 2020;43:913-917.Diabetes Care2020
32231298Beta cell-specific CD8<sup>+</sup> T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes.Nat Immunol2020
32291282Hybrid Insulin Peptides Are Recognized by Human T Cells in the Context of DRB1*04:01.Diabetes2020
30530850Proinsulin Secretion Is a Persistent Feature of Type 1 Diabetes.Diabetes Care2019
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Collaborators

Carla J Greenbaum
Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 41
Jane H Buckner
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 11
Peter S Linsley
8Benaroya Research Institute
Co-authored papers 11
Sarah Alice Long
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 11
William W Kwok
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 10
Gerald T Nepom
Wash Benaroya Research Institute at Virginia Mason
Co-authored papers 10
Karen Cerosaletti
Center for Translational Immunology
Co-authored papers 9
Vivian H Gersuk
Center for Systems Immunology, Benaroya Research Institute
Co-authored papers 8
Damien Chaussabel
Co-authored papers 7
Colin O'Rourke
Center for Interventional Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 6
Matthew J Dufort
Center for Systems Immunology, Benaroya Research Institute Seattle
Co-authored papers 6
Elisavet Serti
The Henry Jackson Foundation.
Co-authored papers 5
Kevan C Herold
Yale University
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Todd M Brusko
College of Medicine, Diabetes Institute, University of Florida
Co-authored papers 4
Hannah A DeBerg
Benaroya Research Institute at Virginia Mason
Co-authored papers 4
Alice E Wiedeman
Center for Translational Immunology, Benaroya Research Institute at Virginia Mason
Co-authored papers 4
Scott Presnell
Benaroya Research Institute
Co-authored papers 3
Clive Wasserfall
Co-authored papers 3
Georgios I Papachristou
The Ohio State University, Wexner Medical Center
Co-authored papers 3
Dhiraj Yadav
University of Pittsburgh Medical Center
Co-authored papers 3
Phil A Hart
Co-authored papers 3
Mario G Rosasco
Center for Systems Immunology, Benaroya Research Institute
Co-authored papers 3
Elisa Balmas
Center for Translational Immunology
Co-authored papers 3
Mark O Goodarzi
Co-authored papers 3
Jerry L Nadler
Co-authored papers 2
Raphael Gottardo
Fred Hutchinson Cancer Center
Co-authored papers 2
Stephen S Rich
Co-authored papers 2
Elisabeth Israelsson
Benaroya Research Institute at Virginia Mason
Co-authored papers 2
Erik Wambre
Precision Immunology Institute, Icahn School of Medicine at Mount Sinai
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Release 1.2