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Author Details

Klaus Schughart
University of Tennessee Health Science Center
1982
142
37
PMIDPaper TitleJournal TitlePublished Year
36423831Inhibition of p38 signaling curtails the SARS-CoV-2 induced inflammatory response but retains the IFN-dependent antiviral defense of the lung epithelial barrier.Antiviral Res2023
37277327Hamster model for post-COVID-19 alveolar regeneration offers an opportunity to understand post-acute sequelae of SARS-CoV-2.Nat Commun2023
34825965Exogenous and Endogenous Triggers Differentially Stimulate Pigr Expression and Antibacterial Secretory Immunity in the Murine Respiratory Tract.Lung2022
36445861Correction: Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection.PLoS Pathog2022
36346236Predicting Influenza A Virus Infection in the Lung from Hematological Data with Machine Learning.mSystems2022
35056627<i>Toxocara canis</i>- and <i>Toxocara cati</i>-Induced Neurotoxocarosis Is Associated with Comprehensive Brain Transcriptomic Alterations.Microorganisms2022
35025971Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection.PLoS Pathog2022
33275160OP7, a novel influenza A virus defective interfering particle: production, purification, and animal experiments demonstrating antiviral potential.Appl Microbiol Biotechnol2021
33627703Highly dampened blood transcriptome response in HIV patients after influenza infection.Sci Rep2021
33488611Genetic Dissection of the Regulatory Mechanisms of <i>Ace2</i> in the Infected Mouse Lung.Front Immunol2021
33640018Blood transcriptome analysis of patients with uncomplicated bacterial infection and sepsis.BMC Res Notes2021
34637789Impaired beta-oxidation increases vulnerability to influenza A infection.J Biol Chem2021
34777354The Host Response to Viral Infections Reveals Common and Virus-Specific Signatures in the Peripheral Blood.Front Immunol2021
34453370Quantitative trait locus mapping identifies a locus linked to striatal dopamine and points to collagen IV alpha-6 chain as a novel regulator of striatal axonal branching in mice.Genes Brain Behav2021
33994946Long-Term Consequence of Non-neurotropic H3N2 Influenza A Virus Infection for the Progression of Alzheimer's Disease Symptoms.Front Cell Neurosci2021
33941189Cell culture-based production and in vivo characterization of purely clonal defective interfering influenza virus particles.BMC Biol2021
34059750Author Correction: Highly dampened blood transcriptome response in HIV patients after respiratory infection.Sci Rep2021
33408218Prospective validation study of prognostic biomarkers to predict adverse outcomes in patients with COVID-19: a study protocol.BMJ Open2021
32321537H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice.Virol J2020
32060626A comprehensive and comparative phenotypic analysis of the collaborative founder strains identifies new and known phenotypes.Mamm Genome2020
33173537<i>Pituitary Tumor Transforming Gene 1</i> Orchestrates Gene Regulatory Variation in Mouse Ventral Midbrain During Aging.Front Genet2020
32303635Transcriptome profiling and protease inhibition experiments identify proteases that activate H3N2 influenza A and influenza B viruses in murine airways.J Biol Chem2020
32348764Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross.Cell Rep2020
30429335Endosomal Toll-Like Receptors 7 and 9 Cooperate in Detection of Murine Gammaherpesvirus 68 Infection.J Virol2019
31826721Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities.Emerg Microbes Infect2019
31557153Multiplex profiling of inflammation-related bioactive lipid mediators in Toxocara canis- and Toxocara cati-induced neurotoxocarosis.PLoS Negl Trop Dis2019
31099738Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis.J Gen Virol2019
29487124Long-Term Neuroinflammation Induced by Influenza A Virus Infection and the Impact on Hippocampal Neuron Morphology and Function.J Neurosci2018
30084768Exchange of amino acids in the H1-haemagglutinin to H3 residues is required for efficient influenza A virus replication and pathology in Tmprss2 knock-out mice.J Gen Virol2018
29976755TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1.J Biol Chem2018
29947965Of mice and men: the host response to influenza virus infection.Mamm Genome2018
27811478Deletion of Irf3 and Irf7 Genes in Mice Results in Altered Interferon Pathway Activation and Granulocyte-Dominated Inflammatory Responses to Influenza A Infection.J Innate Immun2017
28377766Host Genetic Background Strongly Affects Pulmonary microRNA Expression before and during Influenza A Virus Infection.Front Immunol2017
28148793Mutations during the Adaptation of H9N2 Avian Influenza Virus to the Respiratory Epithelium of Pigs Enhance Sialic Acid Binding Activity and Virulence in Mice.J Virol2017
29102108Increased virulence of a PB2/HA mutant of an avian H9N2 influenza strain after three passages in porcine differentiated airway epithelial cells.Vet Microbiol2017
28697377Absence of regulator of G-protein signaling 4 does not protect against dopamine neuron dysfunction and injury in the mouse 6-hydroxydopamine lesion model of Parkinson's disease.Neurobiol Aging2017
28619954A novel immune biomarker <i>IFI27</i> discriminates between influenza and bacteria in patients with suspected respiratory infection.Eur Respir J2017
27933529QTL Mapping and Identification of Candidate Genes in DO Mice: A Use Case Model Derived from a Benzene Toxicity Experiment.Methods Mol Biol2017
26969150TLR8 regulation of LILRA3 in monocytes is abrogated in human immunodeficiency virus infection and correlates to CD4 counts and virus loads.Retrovirology2016
27193691Genetically diverse CC-founder mouse strains replicate the human influenza gene expression signature.Sci Rep2016
27405649Identification of specific residues in avian influenza A virus NS1 that enhance viral replication and pathogenicity in mammalian systems.J Gen Virol2016
26889029The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases.J Virol2016
27088501Respiratory Mucosal Proteome Quantification in Human Influenza Infections.PLoS One2016
26817701Lst1 deficiency has a minor impact on course and outcome of the host response to influenza A H1N1 infections in mice.Virol J2016
26921172Influenza H3N2 infection of the collaborative cross founder strains reveals highly divergent host responses and identifies a unique phenotype in CAST/EiJ mice.BMC Genomics2016
25843806Microarray gene expression analysis reveals major differences between Toxocara canis and Toxocara cati neurotoxocarosis and involvement of T. canis in lipid biosynthetic processes.Int J Parasitol2015
26329040RNAseq expression analysis of resistant and susceptible mice after influenza A virus infection identifies novel genes associated with virus replication and important for host resistance to infection.BMC Genomics2015
26716013CD11b(+)Ly6C(++)Ly6G(-) Cells with Suppressive Activity Towards T Cells Accumulate in Lungs of Influenza a Virus-Infected Mice.Eur J Microbiol Immunol (Bp)2015
26047817Hematological parameters in the early phase of influenza A virus infection in differentially susceptible inbred mouse strains.BMC Res Notes2015
26202236Protection from Severe Influenza Virus Infections in Mice Carrying the Mx1 Influenza Virus Resistance Gene Strongly Depends on Genetic Background.J Virol2015
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Collaborators

Helmholtz Centre for Infection Research
Co-authored papers 18
University of North Carolina at Chapel Hill
Co-authored papers 9
Mayo Clinic
Co-authored papers 8
German Center for Diabetes Research (DZD e.V.)
Co-authored papers 7
William Harvey Research Institute, Queen Mary University of London
Co-authored papers 6
Institute of Experimental Genetics, German Mouse Clinic
Co-authored papers 6
University of Cambridge
Co-authored papers 6
the University of Texas Health Science Center at Houston
Co-authored papers 5
University of Groningen, University Medical Center Groningen
Co-authored papers 5
Institute of Developmental Genetics, German Research Center for Environmental Health
Co-authored papers 4
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University of North Carolina at Chapel Hill.
Co-authored papers 4
Helmholtz Centre for Infection Research
Co-authored papers 4
University of Sydney Nepean Clinical School, Nepean Hospital
Co-authored papers 3
University of Tennessee Health Science Center
Co-authored papers 3
Institute of Experimental Genetics, German Mouse Clinic
Co-authored papers 3
University of North Carolina School of Medicine
Co-authored papers 2
University of North Carolina
Co-authored papers 2
German Research Centre for Environmental Health
Co-authored papers 2
Co-authored papers 2
Co-authored papers 2
Groningen Research Institute of Pharmacy, University of Groningen
Co-authored papers 2
Co-authored papers 2
German Center for Diabetes Research (DZD)
Co-authored papers 2
University of Tennessee Health Science Center
Co-authored papers 1
University Hospital Essen, University of Duisburg-Essen, Institute for Virology
Co-authored papers 1
Monterotondo Mouse Clinic (MMC), Italian National Research Council (CNR)
Co-authored papers 1
University of California
Co-authored papers 1
University of Washington
Co-authored papers 1
The University of North Carolina at Chapel Hill
Co-authored papers 1