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Author Details

James H Hurley
University of California Berkeley
1989
221
84
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36367440Longin domain GAP complexes in nutrient signalling, membrane traffic and neurodegeneration.FEBS Lett2023
37693477Tau fibrils induce nanoscale membrane damage and nucleate cytosolic tau at lysosomes.bioRxiv2023
37218128Dynamics of upstream ESCRT organization at the HIV-1 budding site.Biophys J2023
37273223Toward a standard model for autophagosome biogenesis.J Cell Biol2023
37131815Kinetic investigation reveals an HIV-1 Nef-dependent increase in AP-2 recruitment and productivity at endocytic sites.bioRxiv2023
36697823Structure of the lysosomal mTORC1-TFEB-Rag-Ragulator megacomplex.Nature2023
36804703Amino acid sensing and lysosomal signaling complexes.Curr Opin Struct Biol2023
36791199Structural basis for ATG9A recruitment to the ULK1 complex in mitophagy initiation.Sci Adv2023
36261523Clathrin-associated AP-1 controls termination of STING signalling.Nature2022
35858336Friction-driven membrane scission by the human ESCRT-III proteins CHMP1B and IST1.Proc Natl Acad Sci U S A2022
35994655In vitro reconstitution of calcium-dependent recruitment of the human ESCRT machinery in lysosomal membrane repair.Proc Natl Acad Sci U S A2022
36269825Self-assembly and structure of a clathrin-independent AP-1:Arf1 tubular membrane coat.Sci Adv2022
33442695Crystallographic molecular replacement using an <i>in silico</i>-generated search model of SARS-CoV-2 ORF8.bioRxiv2021
33625752Crystallographic molecular replacement using an in silico-generated search model of SARS-CoV-2 ORF8.Protein Sci2021
33903736Autophagosome biogenesis comes out of the black box.Nat Cell Biol2021
33893090Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy.Sci Adv2021
33983947Identification of recombinant Fabs for structural and functional characterization of HIV-host factor complexes.PLoS One2021
34145292Structural basis for the ARF GAP activity and specificity of the C9orf72 complex.Nat Commun2021
33361333Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein.Proc Natl Acad Sci U S A2021
32424346A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission.Nat Struct Mol Biol2020
32632011Structural basis for autophagy inhibition by the human Rubicon-Rab7 complex.Proc Natl Acad Sci U S A2020
32938689The ESCRTs - converging on mechanism.J Cell Sci2020
32848248Structure of the C9orf72 ARF GAP complex that is haploinsufficient in ALS and FTD.Nature2020
32900948Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes.Proc Natl Acad Sci U S A2020
32869027Structure of SARS-CoV-2 ORF8, a rapidly evolving coronavirus protein implicated in immune evasion.bioRxiv2020
32868926Structural mechanism for amino acid-dependent Rag GTPase nucleotide state switching by SLC38A9.Nat Struct Mol Biol2020
32339216A firehose for phospholipids.J Cell Biol2020
32437499A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy.J Cell Biol2020
32516362ULK complex organization in autophagy by a C-shaped FIP200 N-terminal domain dimer.J Cell Biol2020
30581147Bidirectional Control of Autophagy by BECN1 BARA Domain Dynamics.Mol Cell2019
31672913Structural mechanism of a Rag GTPase activation checkpoint by the lysosomal folliculin complex.Science2019
31578291How HIV Nef Proteins Hijack Membrane Traffic To Promote Infection.J Virol2019
31566566Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy.Elife2019
31447307Structural Basis for Tetherin Antagonism as a Barrier to Zoonotic Lentiviral Transmission.Cell Host Microbe2019
31591221Structural pathway for allosteric activation of the autophagic PI 3-kinase complex I.Proc Natl Acad Sci U S A2019
30811270Regulation of LC3 lipidation by the autophagy-specific class III phosphatidylinositol-3 kinase complex.Mol Biol Cell2019
30894086The BARA necessities of PtdIns 3-kinase activation in autophagy.Autophagy2019
31066340How RB1CC1/FIP200 claws its way to autophagic engulfment of SQSTM1/p62-ubiquitin condensates.Autophagy2019
30853400FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates.Mol Cell2019
30653311Retro Styles for Vesicle Coats.Biochemistry2019
29321502The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading.Nat Commun2018
30053425HIV-1 Nefs Are Cargo-Sensitive AP-1 Trimerization Switches in Tetherin Downregulation.Cell2018
30154094Inside job: how the ESCRTs release HIV-1 from infected cells.Biochem Soc Trans2018
30061680A nutrient-induced affinity switch controls mTORC1 activation by its Rag GTPase-Ragulator lysosomal scaffold.Nat Cell Biol2018
30573630ATP-dependent force generation and membrane scission by ESCRT-III and Vps4.Science2018
30514815Structural mechanism for HIV-1 TAR loop recognition by Tat and the super elongation complex.Proc Natl Acad Sci U S A2018
29540529The dynamic Atg13-free conformation of the Atg1 EAT domain is required for phagophore expansion.Mol Biol Cell2018
27703243Reverse-topology membrane scission by the ESCRT proteins.Nat Rev Mol Cell Biol2017
28087262Molecular Mechanisms of Autophagy-Part B.J Mol Biol2017
28134250Structural basis for ELL2 and AFF4 activation of HIV-1 proviral transcription.Nat Commun2017
  • 1 - 50 of 221

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Collaborators

Goran Stjepanovic
Kobilka Institute of Innovative Drug Discovery, The Chinese University of Hong Kong
Co-authored papers 13
Gerhard Hummer
Max Planck Institute of Biophysics
Co-authored papers 11
Robert M Stroud
University of California San Francisco
Co-authored papers 5
Alasdair C Steven
National Institutes of Health
Co-authored papers 3
Ursula Schulze-Gahmen
Gladstone Institute of Virology, Gladstone Institutes San Francisco CA USA .
Co-authored papers 3
Scott D Emr
Weill Institute for Cell and Molecular Biology, Cornell University
Co-authored papers 3
Thomas J Begley
University at Albany
Co-authored papers 2
Gregory A Voth
Co-authored papers 2
Sovan Sarkar
CRUK MRC Oxford Institute for Radiation Oncology, University of Oxford
Co-authored papers 2
Malene Hansen
Sanford Burnham Prebys Medical Discovery Institute
Co-authored papers 2
Kun-Liang Guan
University of California San Diego
Co-authored papers 2
Ana Maria Cuervo
Albert Einstein College of Medicine
Co-authored papers 2
Laura Santambrogio
Weill Cornell School of Medicine
Co-authored papers 2
Ioannis P Nezis
University of Warwick
Co-authored papers 2
Scott J Bultman
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill
Co-authored papers 2
Masashi Narita
Co-authored papers 2
Karin Przyklenk
Co-authored papers 2
Jason E Gestwicki
Institute for Neurodegenerative Diseases, University of California San Francisco
Co-authored papers 2
Svetlana Dokudovskaya
CNRS UMR9018, Institut Gustave Roussy, Universite Paris-Saclay
Co-authored papers 2
Hirotaka Watada
Co-authored papers 2
Beverly Wendland
Co-authored papers 2
Sara Cherry
University of Pennsylvania
Co-authored papers 2
Carlos L??pez-Ot??n
Instituto Universitario de Oncologia, Universidad de Oviedo
Co-authored papers 2
David Sulzer
New York State Psychiatric Institute, Research Foundation for Mental Hygiene
Co-authored papers 2
David M Sabatini
Whitehead Institute for Biomedical Research and Massachusetts Institute of Technology
Co-authored papers 2
J. Wade Harper
Harvard Medical School
Co-authored papers 2
Nikolai V Gorbunov
Armed Forces Radiobiology Research Institute
Co-authored papers 2
Juan Fueyo
The University of Texas M.D. Anderson Cancer Center
Co-authored papers 2
Qiang Zhou
The University of Hong Kong
Co-authored papers 2
Lawrence H Boise
Winship Cancer Institute, Emory University
Co-authored papers 2
Release 1.2