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Author Details

Stephen P Jackson
Mission Therapeutics Ltd. Glenn Berge Building
1987
322
123
Trey Ideker (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36781955Revolutionizing DNA repair research and cancer therapy with CRISPR-Cas screens.Nat Rev Mol Cell Biol2023
37601970Large-scale exome sequence analysis identifies sex- and age-specific determinants of obesity.Cell Genom2023
38055822RAD54L2 counters TOP2-DNA adducts to promote genome stability.Sci Adv2023
37957154Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson's disease mouse model.Nat Commun2023
37492888Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity.EMBO J2023
36781955Revolutionizing DNA repair research and cancer therapy with CRISPR-Cas screens.Nat Rev Mol Cell Biol2023
37957154Knockout or inhibition of USP30 protects dopaminergic neurons in a Parkinson's disease mouse model.Nat Commun2023
38055822RAD54L2 counters TOP2-DNA adducts to promote genome stability.Sci Adv2023
37601970Large-scale exome sequence analysis identifies sex- and age-specific determinants of obesity.Cell Genom2023
37492888Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity.EMBO J2023
36121125SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling.EMBO J2022
35764636SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination.Nat Commun2022
36121125SOX9 maintains human foetal lung tip progenitor state by enhancing WNT and RTK signalling.EMBO J2022
35764636SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination.Nat Commun2022
34329458Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress.Nucleic Acids Res2021
33637726Combinatorial CRISPR screen identifies fitness effects of gene paralogues.Nat Commun2021
33888558Interfaces between cellular responses to DNA damage and cancer immunotherapy.Genes Dev2021
33764464Mutagenic mechanisms of cancer-associated DNA polymerase ϵ alleles.Nucleic Acids Res2021
34329458Loss of Cyclin C or CDK8 provides ATR inhibitor resistance by suppressing transcription-associated replication stress.Nucleic Acids Res2021
33764464Mutagenic mechanisms of cancer-associated DNA polymerase ϵ alleles.Nucleic Acids Res2021
33637726Combinatorial CRISPR screen identifies fitness effects of gene paralogues.Nat Commun2021
33888558Interfaces between cellular responses to DNA damage and cancer immunotherapy.Genes Dev2021
32375023CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions.Structure2020
32375023CCDC61/VFL3 Is a Paralog of SAS6 and Promotes Ciliary Functions.Structure2020
32042076Chronic irradiation of human cells reduces histone levels and deregulates gene expression.Sci Rep2020
32041954PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1.Nat Commun2020
32441252Parallel CRISPR-Cas9 screens clarify impacts of p53 on screen performance.Elife2020
32919786The phosphoinositide 3-kinase inhibitor alpelisib restores actin organization and improves proximal tubule dysfunction in vitro and in a mouse model of Lowe syndrome and Dent disease.Kidney Int2020
32918070Author Correction: PGBD5 promotes site-specific oncogenic mutations in human tumors.Nat Genet2020
32968016Trajectory and uniqueness of mutational signatures in yeast mutators.Proc Natl Acad Sci U S A2020
32042076Chronic irradiation of human cells reduces histone levels and deregulates gene expression.Sci Rep2020
32041954PALB2 chromatin recruitment restores homologous recombination in BRCA1-deficient cells depleted of 53BP1.Nat Commun2020
32919786The phosphoinositide 3-kinase inhibitor alpelisib restores actin organization and improves proximal tubule dysfunction in vitro and in a mouse model of Lowe syndrome and Dent disease.Kidney Int2020
32918070Author Correction: PGBD5 promotes site-specific oncogenic mutations in human tumors.Nat Genet2020
32968016Trajectory and uniqueness of mutational signatures in yeast mutators.Proc Natl Acad Sci U S A2020
32441252Parallel CRISPR-Cas9 screens clarify impacts of p53 on screen performance.Elife2020
30622252ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.Nat Commun2019
31748747Genetic predisposition to mosaic Y chromosome loss in blood.Nature2019
31729360MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance.Nat Commun2019
30650353Microtubules Deform the Nuclear Membrane and Disrupt Nucleocytoplasmic Transport in Tau-Mediated Frontotemporal Dementia.Cell Rep2019
30622252ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.Nat Commun2019
31525021Small-Molecule Inhibition of UBE2T/FANCL-Mediated Ubiquitylation in the Fanconi Anemia Pathway.ACS Chem Biol2019
31511699Genome architecture and stability in the Saccharomyces cerevisiae knockout collection.Nature2019
30982602A Compendium of Mutational Signatures of Environmental Agents.Cell2019
30976101Retraction Note: KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling.Nature2019
30975768Retraction.Science2019
31160788Derivation and maintenance of mouse haploid embryonic stem cells.Nat Protoc2019
31729360MDC1 PST-repeat region promotes histone H2AX-independent chromatin association and DNA damage tolerance.Nat Commun2019
31748747Genetic predisposition to mosaic Y chromosome loss in blood.Nature2019
31525021Small-Molecule Inhibition of UBE2T/FANCL-Mediated Ubiquitylation in the Fanconi Anemia Pathway.ACS Chem Biol2019
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Collaborators

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Co-authored papers 8
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Co-authored papers 8
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Co-authored papers 6
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Co-authored papers 5
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Co-authored papers 5
University of Calgary, 0 Hospital Drive NW
Co-authored papers 4
Institute of Cell Biology, University of Edinburgh
Co-authored papers 3
Ann & Robert H. Lurie Children's Hospital of Chicago
Co-authored papers 3
Co-authored papers 3
Co-authored papers 3
Co-authored papers 3
Co-authored papers 3
Co-authored papers 3
Co-authored papers 3
Co-authored papers 3
Memorial Sloan Kettering Cancer Center
Co-authored papers 3
Center for Cancer Research, Comprehensive Cancer Centre, Medical University of Vienna
Co-authored papers 3
CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences
Co-authored papers 3
Co-authored papers 3
Memorial Sloan-Kettering Cancer Center
Co-authored papers 3
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Boston Children's Hospital, USA Harvard Medical School, Harvard Medical School
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Variant Bio Inc.
Co-authored papers 3
University of Massachusetts Medical School
Co-authored papers 3