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Author Details

P??l Stenmark
Stockholm University
2001
108
31
Emma Lundberg (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
37746829The cryo-EM structure of the BoNT/Wo-NTNH complex reveals two immunoglobulin-like domains.FEBS J2024
36128847Optimization of N-Piperidinyl-Benzimidazolone Derivatives as Potent and Selective Inhibitors of 8-Oxo-Guanine DNA Glycosylase 1.ChemMedChem2023
37421204A Versatile Synaptotagmin-1 Nanobody Provides Perturbation-Free Live Synaptic Imaging And Low Linkage-Error in Super-Resolution Microscopy.Small Methods2023
36403098Crystal structure of the OrfX1-OrfX3 complex from the PMP1 neurotoxin gene cluster.FEBS Lett2023
36712025Structure and activity of botulinum neurotoxin X.bioRxiv2023
35228749Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress.Nat Cancer2022
35737787Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function.Science2022
35732208Nudix hydrolase 18 catalyzes the hydrolysis of active triphosphate metabolites of the antivirals remdesivir, ribavirin, and molnupiravir.J Biol Chem2022
35577776A nucleotide-sensing oligomerization mechanism that controls NrdR-dependent transcription of ribonucleotide reductases.Nat Commun2022
35712863The First Structure of Human MTHFD2L and Its Implications for the Development of Isoform-Selective Inhibitors.ChemMedChem2022
35914774Reaction Mechanism of Human PAICS Elucidated by Quantum Chemical Calculations.J Am Chem Soc2022
34941255Structural and Biochemical Investigation of Class I Ribonucleotide Reductase from the Hyperthermophile <i>Aquifex aeolicus</i>.Biochemistry2022
33162212Structural and functional analysis of the inhibition of equine glutathione transferase A3-3 by organotin endocrine disrupting pollutants.Environ Pollut2021
33602843Re-engineering Botox.Science2021
33753169Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.J Biol Chem2021
35050991Structural Analysis of Botulinum Neurotoxins Type B and E by Cryo-EM.Toxins (Basel)2021
34489474Structure of the native pyruvate dehydrogenase complex reveals the mechanism of substrate insertion.Nat Commun2021
34361086Mechanism of Ganglioside Receptor Recognition by Botulinum Neurotoxin Serotype E.Int J Mol Sci2021
34234136NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir.Nat Commun2021
34192523NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir.Cell Chem Biol2021
31792680The Structure and Classification of Botulinum Toxins.Handb Exp Pharmacol2021
32144205MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool.J Biol Chem2020
31845319Structure and steroid isomerase activity of Drosophila glutathione transferase E14 essential for ecdysteroid biosynthesis.FEBS Lett2020
31809018Synaptotagmin Binding to Botulinum Neurotoxins.Biochemistry2020
31954130The First Structure of an Active Mammalian dCTPase and its Complexes With Substrate Analogs and Products.J Mol Biol2020
32094176Massively parallel variant characterization identifies <i>NUDT15</i> alleles associated with thiopurine toxicity.Proc Natl Acad Sci U S A2020
33211885Targeting OGG1 arrests cancer cell proliferation by inducing replication stress.Nucleic Acids Res2020
32690945Development of a chemical probe against NUDT15.Nat Chem Biol2020
32883811A ribonucleotide reductase from <i>Clostridium botulinum</i> reveals distinct evolutionary pathways to regulation via the overall activity site.J Biol Chem2020
32571877Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target.J Biol Chem2020
32957706Structural and Biochemical Characterization of Botulinum Neurotoxin Subtype B2 Binding to Its Receptors.Toxins (Basel)2020
32182233Characterization of a membrane binding loop leads to engineering botulinum neurotoxin B with improved therapeutic efficacy.PLoS Biol2020
30614695Crystal Structure and Substrate Specificity of the 8-oxo-dGTP Hydrolase NUDT1 from Arabidopsis thaliana.Biochemistry2019
31676755Author Correction: Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.Nat Commun2019
31562305The ALFA-tag is a highly versatile tool for nanobody-based bioscience applications.Nat Commun2019
31253776A neurotoxin that specifically targets Anopheles mosquitoes.Nat Commun2019
31537648Structural basis for the interaction of the chaperone Cbp3 with newly synthesized cytochrome <i>b</i> during mitochondrial respiratory chain assembly.J Biol Chem2019
31127856Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs.FEBS Lett2019
31111466Crystal structure of the catalytic domain of the Weissella oryzae botulinum-like toxin.FEBS Lett2019
30746458Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models.Sci Adv2019
30388027Botulinum and Tetanus Neurotoxins.Annu Rev Biochem2019
29343827Targeted NUDT5 inhibitors block hormone signaling in breast cancer cells.Nat Commun2018
29900613Germline variation in the oxidative DNA repair genes NUDT1 and OGG1 is not associated with hereditary colorectal cancer or polyposis.Hum Mutat2018
30539762Cotranslational Folding of a Pentarepeat β-Helix Protein.J Mol Biol2018
30442810Small-molecule inhibitor of OGG1 suppresses proinflammatory gene expression and inflammation.Science2018
30304478MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP.Nucleic Acids Res2018
29649119Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding.Toxins (Basel)2018
29413322Human NUDT22 Is a UDP-Glucose/Galactose Hydrolase Exhibiting a Unique Structural Fold.Structure2018
29540745Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity.Sci Rep2018
29396040Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium.Cell Host Microbe2018
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Collaborators

Thomas Helleday
The University of Sheffield
Co-authored papers 32
Ann-Sofie Jemth
Karolinska Institutet
Co-authored papers 29
P??r Nordlund
Karolinska Institutet, BioClinicum J6
Co-authored papers 21
Ronnie P-A Berntsson
Umea University
Co-authored papers 15
Olga Loseva
Karolinska Institutet
Co-authored papers 14
Megan Carter
Stockholm University
Co-authored papers 9
Maria H??ggblad
Karolinska Institute
Co-authored papers 5
Jordi Carreras Puigvert
Department of Pharmaceutical Biosciences, Uppsala University
Co-authored papers 5
Mikael Altun
Karolinska Institutet
Co-authored papers 5
Ulf Martens
Stockholm University
Co-authored papers 4
Per Artursson
Department of Pharmacy, Uppsala University
Co-authored papers 4
Susanne Gr??slund
Karolinska Institutet
Co-authored papers 4
Judith E Unterlass
Karolinska Institute
Co-authored papers 4
Raymond C Stevens
iHuman Institute, ShanghaiTech University
Co-authored papers 3
Bo Lundgren
Stockholm University
Co-authored papers 3
Nina Gustafsson
Karolinska Institutet
Co-authored papers 3
Jos?? Manuel Calder??n-Monta??o
Faculty of Pharmacy, University of Seville
Co-authored papers 2
Stefan Knapp
Institute of Pharmaceutical Chemistry, Goethe University
Co-authored papers 2
Janne Lehti??
Karolinska Institutet
Co-authored papers 2
Johan Bostr??m
Karolinska Institutet
Co-authored papers 2
Damian J Matuszewski
Uppsala University
Co-authored papers 1
Mary V Relling
Departments of Pharmaceutical Sciences.
Co-authored papers 1
Smita Bhatia
Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham
Co-authored papers 1
Michael S Gilmore
Harvard Medical School, USA Infectious Disease Institute (P.J.M.B.
Co-authored papers 1
Cecilia Lindskog
Uppsala University
Co-authored papers 1
Blaz Zupan
University of Ljubljana
Co-authored papers 1
Alfonso Valencia
Josep Carreras Leukaemia Research Institute (IJC)
Co-authored papers 1
Marinka Zitnik
Harvard Medical School
Co-authored papers 1
Zhir Karem
Karolinska Institutet
Co-authored papers 1
Erik L L Sonnhammer
Stockholm University
Co-authored papers 1
Release 1.2