|
| 36493348 | Correction to "Assessing the Activation of Tyrosine Kinase KIT through Free Energy Calculations". | J Chem Theory Comput | 2023 |
| 37725576 | Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma. | Clin Cancer Res | 2023 |
| 37494095 | Searching for molecular hypoxia sensors among oxygen-dependent enzymes. | Elife | 2023 |
| 37254128 | Correction: Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases. | Mol Neurodegener | 2023 |
| 37141099 | Dissecting the effects of GTPase and kinase domain mutations on LRRK2 endosomal localization and activity. | Cell Rep | 2023 |
| 37169961 | Signal peptide mimicry primes Sec61 for client-selective inhibition. | Nat Chem Biol | 2023 |
| 37131250 | Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases. | Mol Neurodegener | 2023 |
| 35089788 | Modulating environmental signals to reveal mechanisms and vulnerabilities of cancer persisters. | Sci Adv | 2022 |
| 36173843 | Structure-based discovery of nonopioid analgesics acting through the α<sub>2A</sub>-adrenergic receptor. | Science | 2022 |
| 36166736 | Assessing the Activation of Tyrosine Kinase KIT through Free Energy Calculations. | J Chem Theory Comput | 2022 |
| 36161872 | Cysteine Oxidation in Proteins: Structure, Biophysics, and Simulation. | Biochemistry | 2022 |
| 36375339 | Fighting Plasmodium chloroquine resistance with acetylenic chloroquine analogues. | Int J Parasitol Drugs Drug Resist | 2022 |
| 32887758 | The Synthesis and Structural Requirements for Measuring Glucocorticoid Receptor Expression In Vivo with (±)-<sup>11</sup>C-YJH08 PET. | J Nucl Med | 2021 |
| 33883744 | Gasdermin D pore structure reveals preferential release of mature interleukin-1. | Nature | 2021 |
| 33904404 | Protomer alignment modulates specificity of RNA substrate recognition by Ire1. | Elife | 2021 |
| 33761256 | A Crowding Barrier to Protein Inhibition in Colloidal Aggregates. | J Med Chem | 2021 |
| 33563661 | Matched Targeted Therapy for Pediatric Patients with Relapsed, Refractory, or High-Risk Leukemias: A Report from the LEAP Consortium. | Cancer Discov | 2021 |
| 33635645 | Mutagenesis, Hydrogen-Deuterium Exchange, and Molecular Docking Investigations Establish the Dimeric Interface of Human Platelet-Type 12-Lipoxygenase. | Biochemistry | 2021 |
| 34500187 | Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2. | Bioorg Med Chem | 2021 |
| 34507163 | Docking and mutagenesis studies lead to improved inhibitor development of ML355 for human platelet 12-lipoxygenase. | Bioorg Med Chem | 2021 |
| 34029049 | <i>In Vitro</i> Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2. | Biochemistry | 2021 |
| 34165961 | Analogs of the Dopamine Metabolite 5,6-Dihydroxyindole Bind Directly to and Activate the Nuclear Receptor Nurr1. | ACS Chem Biol | 2021 |
| 33315406 | Synthesis and Screening of α-Xylosides in Human Glioblastoma Cells. | Mol Pharm | 2021 |
| 32404334 | 15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5. | J Lipid Res | 2020 |
| 33048542 | Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1. | Biochemistry | 2020 |
| 32968273 | Synthetic group A streptogramin antibiotics that overcome Vat resistance. | Nature | 2020 |
| 32324389 | Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators. | Biochemistry | 2020 |
| 30307134 | Structure-based Discovery of Novel CK2α-Binding Cyclic Peptides with Anti-cancer Activity. | Mol Inform | 2019 |
| 31270078 | ATP-Competitive Inhibitors Midostaurin and Avapritinib Have Distinct Resistance Profiles in Exon 17-Mutant KIT. | Cancer Res | 2019 |
| 31398187 | Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response. | PLoS Genet | 2019 |
| 31099551 | Multi-Granulin Domain Peptides Bind to Pro-Cathepsin D and Stimulate Its Enzymatic Activity More Effectively Than Progranulin in Vitro. | Biochemistry | 2019 |
| 30853418 | Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite. | Cell Chem Biol | 2019 |
| 31054975 | Crosstalk between RNA Pol II C-Terminal Domain Acetylation and Phosphorylation via RPRD Proteins. | Mol Cell | 2019 |
| 30878184 | Structure-based identification of novel CK2 inhibitors with a linear 2-propenone scaffold as anti-cancer agents. | Biochem Biophys Res Commun | 2019 |
| 30992364 | Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH. | J Biol Chem | 2019 |
| 30961890 | Conformational Dynamics of the HIV-Vif Protein Complex. | Biophys J | 2019 |
| 30565457 | Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-Type 12-Lipoxygenase. | Biochemistry | 2019 |
| 30690031 | Progranulin Stimulates the In Vitro Maturation of Pro-Cathepsin D at Acidic pH. | J Mol Biol | 2019 |
| 29377793 | Prediction of enzymatic pathways by integrative pathway mapping. | Elife | 2018 |
| 29953808 | Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70). | J Med Chem | 2018 |
| 30532032 | Inhibitor binding mode and allosteric regulation of Na<sup>+</sup>-glucose symporters. | Nat Commun | 2018 |
| 29476136 | A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. | Nat Commun | 2018 |
| 29414793 | High-throughput screen for inhibitors of protein-protein interactions in a reconstituted heat shock protein 70 (Hsp70) complex. | J Biol Chem | 2018 |
| 28874603 | Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins. | Sci Signal | 2017 |
| 28170244 | Structure-Activity Relationship and Molecular Mechanics Reveal the Importance of Ring Entropy in the Biosynthesis and Activity of a Natural Product. | J Am Chem Soc | 2017 |
| 28337324 | Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin. | ACS Med Chem Lett | 2017 |
| 28981251 | Development of 5N-Bicalutamide, a High-Affinity Reversible Covalent Antiandrogen. | ACS Chem Biol | 2017 |
| 29045152 | Discovery of Potent and Orally Bioavailable Macrocyclic Peptide-Peptoid Hybrid CXCR7 Modulators. | J Med Chem | 2017 |
| 29091768 | Evolutionarily Conserved Roles for Blood-Brain Barrier Xenobiotic Transporters in Endogenous Steroid Partitioning and Behavior. | Cell Rep | 2017 |
| 28837668 | Prominent features of the amino acid mutation landscape in cancer. | PLoS One | 2017 |