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Author Details

Dean A Fennell
University of Leicester
1990
170
49
PMIDPaper TitleJournal TitlePublished Year
37421230Gene fusions during the early evolution of mesothelioma correlate with impaired DNA repair and Hippo pathways.Genes Chromosomes Cancer2024
36550359BAP1 loss induces mitotic defects in mesothelioma cells through BRCA1-dependent and independent mechanisms.Oncogene2023
37657465Tumor Treating Fields therapy could potentiate immunotherapy in non-small-cell lung cancer.Lancet Oncol2023
37993149Evaluating niraparib versus active symptom control in patients with previously treated mesothelioma (NERO): a study protocol for a multicentre, randomised, two-arm, open-label phase II trial in UK secondary care centres.BMJ Open2023
35410957Cytoreductive surgery with hyperthermic intrathoracic chemotherapy for malignant pleural mesothelioma: a systematic review.Thorax2023
37167572Family Matters: Germline Testing in Thoracic Cancers.Am Soc Clin Oncol Educ Book2023
34930610Chemotherapy With or Without Bevacizumab Should Be the Standard of Care for First-Line Unresectable Epithelioid Mesothelioma.J Thorac Oncol2022
35654055Abemaciclib for malignant pleural mesothelioma - Authors' reply.Lancet Oncol2022
35706488Active symptom control with or without oral vinorelbine in patients with relapsed malignant pleural mesothelioma (VIM): A randomised, phase 2 trial.EClinicalMedicine2022
35637530Comprehensive genomic and tumour immune profiling reveals potential therapeutic targets in malignant pleural mesothelioma.Genome Med2022
35462085Medical and Surgical Care of Patients With Mesothelioma and Their Relatives Carrying Germline BAP1 Mutations.J Thorac Oncol2022
35358455Anetumab ravtansine versus vinorelbine in patients with relapsed, mesothelin-positive malignant pleural mesothelioma (ARCS-M): a randomised, open-label phase 2 trial.Lancet Oncol2022
35778611Immunotherapy approaches for malignant pleural mesothelioma.Nat Rev Clin Oncol2022
35588752EZH2 inhibitor tazemetostat in patients with relapsed or refractory, BAP1-inactivated malignant pleural mesothelioma: a multicentre, open-label, phase 2 study.Lancet Oncol2022
36505807Corrigendum: <i>CDKN2A</i> determines mesothelioma cell fate to EZH2 inhibition.Front Oncol2022
35999308Accelerating innovations in systemic therapy for pleural mesothelioma.Nat Cancer2022
35990583Olaparib maintenance versus placebo monotherapy in patients with advanced non-small cell lung cancer (PIN): A multicentre, randomised, controlled, phase 2 trial.EClinicalMedicine2022
35157829Abemaciclib in patients with p16ink4A-deficient mesothelioma (MiST2): a single-arm, open-label, phase 2 trial.Lancet Oncol2022
34973224CONFIRM trial: what is the real efficacy of second-line immunotherapy in mesothelioma? - Authors' reply.Lancet Oncol2022
33155719Inclusion of multiple high-risk histopathological criteria improves the prediction of adjuvant chemotherapy efficacy in lung adenocarcinoma.Histopathology2021
33795785Transcriptional perturbation of protein arginine methyltransferase-5 exhibits MTAP-selective oncosuppression.Sci Rep2021
33741915Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment.Nat Commun2021
33515503Rucaparib in patients with BAP1-deficient or BRCA1-deficient mesothelioma (MiST1): an open-label, single-arm, phase 2a clinical trial.Lancet Respir Med2021
34994590Durable Response to Vismodegib in PTCH1 F1147fs Mutant Relapsed Malignant Pleural Mesothelioma: Implications for Mesothelioma Drug Treatment.JCO Precis Oncol2021
34588615Efficacy of CDK4/6 inhibitors in preclinical models of malignant pleural mesothelioma.Br J Cancer2021
34551230Perspectives on the Treatment of Malignant Pleural Mesothelioma.N Engl J Med2021
34518291Matter of TIME: the tumor-immune microenvironment of mesothelioma and implications for checkpoint blockade efficacy.J Immunother Cancer2021
34277422<i>CDKN2A</i> Determines Mesothelioma Cell Fate to EZH2 Inhibition.Front Oncol2021
34099722Author Correction: Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment.Nat Commun2021
34067960Precision Therapy for Mesothelioma: Feasibility and New Opportunities.Cancers (Basel)2021
33158996BRCA1/MAD2L1 Deficiency Disrupts the Spindle Assembly Checkpoint to Confer Vinorelbine Resistance in Mesothelioma.Mol Cancer Ther2021
31065954A phase Ib study of GSK3052230, an FGF ligand trap in combination with pemetrexed and cisplatin in patients with malignant pleural mesothelioma.Invest New Drugs2020
31829907Randomized Phase III Study of Ganetespib, a Heat Shock Protein 90 Inhibitor, With Docetaxel Versus Docetaxel in Advanced Non-Small-Cell Lung Cancer (GALAXY-2).J Clin Oncol2020
32669375Ganetespib in Combination with Pemetrexed-Platinum Chemotherapy in Patients with Pleural Mesothelioma (MESO-02): A Phase Ib Trial.Clin Cancer Res2020
32448904ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma.Eur J Cardiothorac Surg2020
32184261EML4-ALK V3 oncogenic fusion proteins promote microtubule stabilization and accelerated migration through NEK9 and NEK7.J Cell Sci2020
32437439Correction: Generation and Characterisation of Cisplatin-Resistant Non-Small Cell Lung Cancer Cell Lines Displaying a Stem-Like Signature.PLoS One2020
32451346ERS/ESTS/EACTS/ESTRO guidelines for the management of malignant pleural mesothelioma.Eur Respir J2020
31103412Nintedanib in combination with pemetrexed and cisplatin for chemotherapy-naive patients with advanced malignant pleural mesothelioma (LUME-Meso): a double-blind, randomised, placebo-controlled phase 3 trial.Lancet Respir Med2019
31976036Mesothelioma: Hippo pathway as a target, lessons from COMMAND.Oncotarget2019
31329517Reply to K. Masuda et al.J Clin Oncol2019
31470129Radiologic Considerations and Standardization of Malignant Pleural Mesothelioma Imaging Within Clinical Trials: Consensus Statement from the NCI Thoracic Malignancy Steering Committee - International Association for the Study of Lung Cancer - Mesothelioma Applied Research Foundation Clinical Trials Planning Meeting.J Thorac Oncol2019
31406306Cancer-cell death ironed out.Nature2019
31260832Pathologic Considerations and Standardization in Mesothelioma Clinical Trials.J Thorac Oncol2019
31628017Tumour Treating Fields for mesothelioma: controversy versus opportunity.Lancet Oncol2019
31367541A multicenter, randomized, phase II/III study of dendritic cells loaded with allogeneic tumor cell lysate (MesoPher) in subjects with mesothelioma as maintenance therapy after chemotherapy: DENdritic cell Immunotherapy for Mesothelioma (DENIM) trial.Transl Lung Cancer Res2019
30863365When RON MET TAM in Mesothelioma: All Druggable for One, and One Drug for All?Front Endocrinol (Lausanne)2019
30785827Maintenance Defactinib Versus Placebo After First-Line Chemotherapy in Patients With Merlin-Stratified Pleural Mesothelioma: COMMAND-A Double-Blind, Randomized, Phase II Study.J Clin Oncol2019
29345617Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells.Elife2018
30244849Programmed Death 1 Blockade With Nivolumab in Patients With Recurrent Malignant Pleural Mesothelioma.J Thorac Oncol2018
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Collaborators

University of Leicester, Robert Kilpatrick Clinical Sciences Building
Co-authored papers 20
University Hospitals of Leicester NHS Trust
Co-authored papers 16
Beatson Cancer Research Institute, University of Glasgow
Co-authored papers 10
Sheffield Teaching Hospital NHS Trust
Co-authored papers 9
University Hospitals of Leicester NHS Trust
Co-authored papers 9
Co-authored papers 7
Francis Crick Institute
Co-authored papers 7
St Bartholomew's Hospital
Co-authored papers 6
The University of Manchester
Co-authored papers 6
Peking University Third Hospital
Co-authored papers 5
University College London Cancer Institute
Co-authored papers 5
Maastro Clinic
Co-authored papers 4
Co-authored papers 3
University of Leicester
Co-authored papers 3
Memorial Sloan Kettering Cancer Center
Co-authored papers 3
Duke University Medical Center
Co-authored papers 3
The Francis Crick Institute
Co-authored papers 3
Dana-Farber Cancer Institute
Co-authored papers 2
Co-authored papers 2
Harvard Medical School
Co-authored papers 2
The Francis Crick Institute
Co-authored papers 2
University of California at Berkeley
Co-authored papers 2
University Hospital Essen
Co-authored papers 2
Co-authored papers 2
The Princess Margaret Cancer Centre/University of Toronto
Co-authored papers 2
Leicester Clinical Trials Unit, University of Leicester
Co-authored papers 2
University Health Network, University of Toronto
Co-authored papers 2
Oncology Center of Excellence
Co-authored papers 2
Medical University of Bialystok
Co-authored papers 2
National Centre for Asbestos Related Diseases, University of Western Australia
Co-authored papers 2