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Author Details

Alexis Kaushansky
Seattle Children's Research Institute, University of Washington
1977
58
22
Andrej Sali (CM4AI)
PMIDPaper TitleJournal TitlePublished Year
36935339Liver-stage Plasmodium infection tunes clinical outcomes.Trends Parasitol2023
37669940Identification of potent and selective N-myristoyltransferase inhibitors of Plasmodium vivax liver stage hypnozoites and schizonts.Nat Commun2023
38014051Host kinase regulation of <i>Plasmodium vivax</i> dormant and replicating liver stages.bioRxiv2023
37776521Protocol for assembling and implementing a partially automated system for rearing and handling Anopheles stephensi mosquitoes.STAR Protoc2023
37722671Identification of and Structural Insights into Hit Compounds Targeting <i>N</i>-Myristoyltransferase for <i>Cryptosporidium</i> Drug Development.ACS Infect Dis2023
34927415Cyclosporine Induces Fenestra-Associated Injury in Human Renal Microvessels <i>In Vitro</i>.ACS Biomater Sci Eng2022
35738280A genome-wide CRISPR-Cas9 screen identifies CENPJ as a host regulator of altered microtubule organization during Plasmodium liver infection.Cell Chem Biol2022
35793394Germinal center activity and B cell maturation are associated with protective antibody responses against Plasmodium pre-erythrocytic infection.PLoS Pathog2022
36305789Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.J Cell Biol2022
35111697Elucidating Spatially-Resolved Changes in Host Signaling During <i>Plasmodium</i> Liver-Stage Infection.Front Cell Infect Microbiol2022
33450011A systems-level gene regulatory network model for Plasmodium falciparum.Nucleic Acids Res2021
34693368Host-directed therapy, an untapped opportunity for antimalarial intervention.Cell Rep Med2021
34216546Exploiting polypharmacology to dissect host kinases and kinase inhibitors that modulate endothelial barrier integrity.Cell Chem Biol2021
34348141Antibody interference by a non-neutralizing antibody abrogates humoral protection against Plasmodium yoelii liver stage.Cell Rep2021
34197083Host-targeted Interventions as an Exciting Opportunity to Combat Malaria.Chem Rev2021
31065106Liver stage malaria infection is controlled by host regulators of lipid peroxidation.Cell Death Differ2020
31850752Identification of Selective Inhibitors of <i>Plasmodium</i> N-Myristoyltransferase by High-Throughput Screening.J Med Chem2020
33173868Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality.bioRxiv2020
32785687Crippling life support for SARS-CoV-2 and other viruses through synthetic lethality.J Cell Biol2020
31111131Spatial presentation of biological molecules to cells by localized diffusive transfer.Lab Chip2019
31731198Plasmodium Secretion Induces Hepatocyte Lysosome Exocytosis and Promotes Parasite Entry.iScience2019
31295425Exciting Contributions to the Cryptosporidium Renaissance.Cell Host Microbe2019
31492649A Molecular Signature in Blood Reveals a Role for p53 in Regulating Malaria-Induced Inflammation.Immunity2019
30893610Alterations in Phosphorylation of Hepatocyte Ribosomal Protein S6 Control Plasmodium Liver Stage Infection.Cell Rep2019
29253313Plasmodium yoelii S4/CelTOS is important for sporozoite gliding motility and cell traversal.Cell Microbiol2018
30122551Opportunities for Host-targeted Therapies for Malaria.Trends Parasitol2018
30352947A call to arms: Unifying the fight against resistance.Sci Signal2018
30274514Next Generation Histology-Directed Imaging Mass Spectrometry Driven by Autofluorescence Microscopy.Anal Chem2018
29089541Identifying host regulators and inhibitors of liver stage malaria infection using kinase activity profiles.Nat Commun2017
29201016The Promise of Systems Biology Approaches for Revealing Host Pathogen Interactions in Malaria.Front Microbiol2017
25312960Susceptibility to Plasmodium yoelii preerythrocytic infection in BALB/c substrains is determined at the point of hepatocyte invasion.Infect Immun2015
26450378Flow Cytometry-Based Assessment of Antibody Function Against Malaria Pre-erythrocytic Infection.Methods Mol Biol2015
26612952Malaria parasites target the hepatocyte receptor EphA2 for successful host infection.Science2015
26102161Selection and refinement: the malaria parasite's infection and exploitation of host hepatocytes.Curr Opin Microbiol2015
26138101Host ER stress during malaria parasite infection.EMBO Rep2015
25648263Host-based Prophylaxis Successfully Targets Liver Stage Malaria Parasites.Mol Ther2015
24478094Model for in vivo assessment of humoral protection against malaria sporozoite challenge by passive transfer of monoclonal antibodies and immune serum.Infect Immun2014
25480637Systems biology of megakaryocytes.Adv Exp Med Biol2014
24827907A next-generation genetically attenuated Plasmodium falciparum parasite created by triple gene deletion.Mol Ther2014
24612025Susceptibility to Plasmodium liver stage infection is altered by hepatocyte polyploidy.Cell Microbiol2014
24582635Immunization with genetically attenuated P. falciparum parasites induces long-lived antibodies that efficiently block hepatocyte invasion by sporozoites.Vaccine2014
24607955Phosphorylated c-Mpl tyrosine 591 regulates thrombopoietin-induced signaling.Exp Hematol2014
24506682Of men in mice: the success and promise of humanized mouse models for human malaria parasite infections.Cell Microbiol2014
23358503Phosphotyrosine signaling proteins that drive oncogenesis tend to be highly interconnected.Mol Cell Proteomics2013
23928701Malaria parasite liver stages render host hepatocytes susceptible to mitochondria-initiated apoptosis.Cell Death Dis2013
23478020Suppression of host p53 is critical for Plasmodium liver-stage infection.Cell Rep2013
22342965Development of a quantitative flow cytometry-based assay to assess infection by Plasmodium falciparum sporozoites.Mol Biochem Parasitol2012
22996664Complete Plasmodium falciparum liver-stage development in liver-chimeric mice.J Clin Invest2012
21527831Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling.Cell Cycle2011
21988987The crucial role of hepatocyte growth factor receptor during liver-stage infection is not conserved among Plasmodium species.Nat Med2011
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Collaborators

John D Aitchison
Center for Global Infectious Disease Research, Seattle Children's Research Institute
Co-authored papers 9
Nadia Arang
Moores Cancer Center, University of California San Diego
Co-authored papers 7
Fred D Mast
Center for Global Infectious Disease Research, Seattle Children's Research Institute
Co-authored papers 6
David Noah Sather
Center for Global Infectious Disease Research, Seattle Children's Hospital
Co-authored papers 4
Nicholas Dambrauskas
Center for Global Infectious Disease Research, Seattle Children's Research Institute
Co-authored papers 4
John Rush
Cell Signaling Technology Inc.
Co-authored papers 4
Alan Aderem
Seattle Children's Research Institute
Co-authored papers 3
Arti T Navare
Center for Global Infectious Disease Research, Seattle Children's Research Institute
Co-authored papers 3
Mike Tyers
Institute for Research in Immunology and Cancer (IRIC), Universite de Montreal
Co-authored papers 3
Maxwell L Neal
Co-authored papers 3
Jasmin Coulombe-Huntington
Institute for Research in Immunology and Cancer, Universite de Montreal
Co-authored papers 3
Vladimir Vigdorovich
Center for Global Infectious Disease Research, Seattle Children's Hospital
Co-authored papers 3
Peter J Myler
University of Guelph
Co-authored papers 3
Nitin S Baliga
Institute for Systems Biology
Co-authored papers 2
Paul Olivier
Center for Global Infectious Disease Research, Seattle Children's Research Institute
Co-authored papers 2
Thomas F Meyer
Max Planck Institute for Infection Biology
Co-authored papers 2
Andrej Sali (CM4AI)
University of California San Francisco
Co-authored papers 1
Charles M Rice
Rockefeller University
Co-authored papers 1
Alejandro Wolf-Yadlin
University of Washington
Co-authored papers 1
Nathan Heath Patterson
Co-authored papers 1
Brian T Chait
The Rockefeller University
Co-authored papers 1
Shreeram Akilesh
Co-authored papers 1
Elise M O'Connell
National Institutes of Health Intramural Research Program
Co-authored papers 1
Almer M van der Sloot
Institute for Research in Immunology and Cancer, Universite de Montreal
Co-authored papers 1
Galit Alter
Co-authored papers 1
Raf Van de Plas
Co-authored papers 1
Bogdan Budnik
Co-authored papers 1
Ewen F Kirkness
J. Craig Venter Institute
Co-authored papers 1
Richard M Caprioli
Mass Spectrometry Research Center, Vanderbilt University
Co-authored papers 1
Kenneth Stuart
Seattle Children's Research Institute
Co-authored papers 1
Release 1.2